Metastatic Carcinoma Follow-up

  • Author: Howard A Chansky, MD; Chief Editor: Harris Gellman, MD   more...
 
Updated: Jun 28, 2011
 

Further Outpatient Care

Most of these patients benefit from outpatient physical therapy. For severely debilitated patients, pain palliation may be the primary goal of surgery; the potential for functional recovery is limited.[22]

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Prognosis

In general, once skeletal metastases are present, patient survival is dramatically shortened. As treatment protocols improve, however, patients are surviving and remaining active for longer periods.[15]

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Contributor Information and Disclosures
Author

Howard A Chansky, MD  Associate Professor, Department of Orthopedics and Sports Medicine, University of Washington Medical Center

Howard A Chansky, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons

Disclosure: Nothing to disclose.

Coauthor(s)

John Eady, MD  Chief, Orthopaedic Surgery, Dorn VA Hospital, Columbia, SC 29209

John Eady, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American College of Surgeons, American Orthopaedic Association, and Southern Medical Association

Disclosure: Nothing to disclose.

Specialty Editor Board

Lynn A Crosby, MD, FACS  Chief of Shoulder Division, Professor, Department of Orthopedic Surgery, Wright State University School of Medicine

Lynn A Crosby, MD, FACS is a member of the following medical societies: Alpha Omega Alpha, American Academy of Orthopaedic Surgeons, American College of Sports Medicine, American College of Surgeons, American Fracture Association, American Medical Association, American Medical Tennis Association, American Orthopaedic Association, American Orthopaedic Foot and Ankle Society, Arthroscopy Association of North America, Mid-America Orthopaedic Association, and Orthopaedic Research Society

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD  Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Salary Employment

Dinesh Patel, MD, FACS  Associate Clinical Professor of Orthopedic Surgery, Harvard Medical School; Chief of Arthroscopic Surgery, Department of Orthopedic Surgery, Massachusetts General Hospital

Dinesh Patel, MD, FACS is a member of the following medical societies: American Academy of Orthopaedic Surgeons

Disclosure: Nothing to disclose.

Chief Editor

Harris Gellman, MD  Consulting Surgeon, Broward Hand Center; Voluntary Clinical Professor of Orthopedic Surgery and Plastic Surgery, Departments of Orthopedic Surgery and Surgery, University of Miami, Leonard M Miller School of Medicine

Harris Gellman, MD is a member of the following medical societies: American Academy of Medical Acupuncture, American Academy of Orthopaedic Surgeons, American Orthopaedic Association, American Society for Surgery of the Hand, and Arkansas Medical Society

Disclosure: Nothing to disclose.

References

  1. Keene JS, Sellinger DS, McBeath AA, et al. Metastatic breast cancer in the femur. A search for the lesion at risk of fracture. Clin Orthop Relat Res. Feb 1986;(203):282-8. [Medline].

  2. Quattrocchi CC, Piciucchi S, Sammarra M, et al. Bone metastases in breast cancer: higher prevalence of osteosclerotic lesions. Radiol Med (Torino). Oct 2007;112(7):1049-59. [Medline].

  3. Alarmo EL, Kallioniemi A. Bone morphogenetic proteins in breast cancer - dual role in tumourigenesis?. Endocr Relat Cancer. Mar 24 2010;[Medline].

  4. Doot RK, Muzi M, Peterson LM, Schubert EK, Gralow JR, Specht JM, et al. Kinetic analysis of 18F-fluoride PET images of breast cancer bone metastases. J Nucl Med. Apr 2010;51(4):521-7. [Medline].

  5. Hung JJ, Jeng WJ, Hsu WH, Wu KJ, Chou TY, Hsieh CC, et al. Prognostic factors of postrecurrence survival in completely resected stage I non-small cell lung cancer with distant metastasis. Thorax. Mar 2010;65(3):241-5. [Medline].

  6. Edwards J. Src kinase inhibitors: an emerging therapeutic treatment option for prostate cancer. Expert Opin Investig Drugs. Apr 5 2010;[Medline].

  7. Yazawa Y, Frassica FJ, Chao EY, et al. Metastatic bone disease. A study of the surgical treatment of 166 pathologic humeral and femoral fractures. Clin Orthop Relat Res. Feb 1990;(251):213-9. [Medline].

  8. Hirbe AC, Morgan EA, Weilbaecher KN. The CXCR4/SDF-1 Chemokine Axis: A Potential Therapeutic Target for Bone Metastases?. Curr Pharm Des. Feb 18 2010;[Medline].

  9. British Association of Surgical Oncology Guidelines. The management of metastatic bone disease in the United Kingdom. The Breast Specialty Group of the British Association of Surgical Oncology. Eur J Surg Oncol. Feb 1999;25(1):3-23. [Medline].

  10. Mundy GR, Yoneda T. Facilitation and suppression of bone metastasis. Clin Orthop Relat Res. Mar 1995;(312):34-44. [Medline].

  11. Guise TA, Yin JJ, Taylor SD, Kumagai Y, Dallas M, Boyce BF, et al. Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis. J Clin Invest. Oct 1 1996;98(7):1544-9. [Medline]. [Full Text].

  12. Mirels H. Metastatic disease in long bones. A proposed scoring system for diagnosing impending pathologic fractures. Clin Orthop Relat Res. Dec 1989;(249):256-64. [Medline].

  13. Hipp JA, Springfield DS, Hayes WC. Predicting pathologic fracture risk in the management of metastatic bone defects. Clin Orthop Relat Res. Mar 1995;(312):120-35. [Medline].

  14. Kawaguchi M, Tateishi U, Shizukuishi K, Suzuki A, Inoue T. (18)F-fluoride uptake in bone metastasis: morphologic and metabolic analysis on integrated PET/CT. Ann Nucl Med. Mar 24 2010;[Medline].

  15. Harrington KD. Orthopedic surgical management of skeletal complications of malignancy. Cancer. Oct 15 1997;80(8 Suppl):1614-27. [Medline]. [Full Text].

  16. Zaikova O, Fosså SD, Bruland OS, Giercksky KE, Sandstad B, Skjeldal S. Radiotherapy or surgery for spine metastases?. Acta Orthop. May 2011;82(3):365-71. [Medline].

  17. Orita Y, Sugitani I, Matsuura M, Ushijima M, Tsukahara K, Fujimoto Y, et al. Prognostic factors and the therapeutic strategy for patients with bone metastasis from differentiated thyroid carcinoma. Surgery. Mar 2010;147(3):424-31. [Medline].

  18. Harrington KD. Orthopaedic management of extremity and pelvic lesions. Clin Orthop Relat Res. Mar 1995;(312):136-47. [Medline].

  19. Clayer MT, Tang X. Low risk of cardiac events during intramedullary instrumentation of lung cancer metastases. Acta Orthop. Aug 2007;78(4):547-50. [Medline]. [Full Text].

  20. Camnasio F, Scotti C, Peretti GM, et al. Prosthetic joint replacement for long bone metastases: analysis of 154 cases. Arch Orthop Trauma Surg. Oct 9 2007;[Medline].

  21. Frankel BM, Jones T, Wang C. Segmental polymethylmethacrylate-augmented pedicle screw fixation in patients with bone softening caused by osteoporosis and metastatic tumor involvement: a clinical evaluation. Neurosurgery. Sep 2007;61(3):531-7; discussion 537-8. [Medline].

  22. Forauer AR, Kent E, Cwikiel W, et al. Selective palliative transcatheter embolization of bony metastases from renal cell carcinoma. Acta Oncol. 2007;46(7):1012-8. [Medline].

 
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Lateral view of the femur of a 70-year-old man with metastatic prostate carcinoma, the most common cause of osteoblastic metastases in men.
Radiograph of a patient with severe rest- and activity-related pain at the time of presentation.
 
 
 
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