eMedicine Specialties > Orthopedic Surgery > Neoplasms

Chondroblastoma: Treatment & Medication

Author: Hannah D Morgan, MD, Consulting Staff, Connecticut Orthopaedic Specialists
Coauthor(s): Timothy A Damron, MD, David G Murray Endowed Professor, Department of Orthopedic Surgery, Professor, Orthopedic Oncology and Adult Reconstruction, Vice Chair, Department of Orthopedics, State University of New York Upstate Medical University at Syracuse
Contributor Information and Disclosures

Updated: Jul 18, 2007

Treatment

Medical Care

Radiation therapy has been employed in the treatment of chondroblastoma but has essentially no current role in its treatment. Chemotherapy has not been reported in the condition's treatment.

Surgical Care

No evidence suggests that chondroblastoma resolves spontaneously, so surgical treatment is indicated. The most common surgical procedure used for chondroblastoma is curettage, with or without autograft or allograft bone grafting. Other options, used less frequently, include substituting polymethylmethacrylate or fat implantation for bone graft, treating the curetted lesion with chemical cauterization (phenol), liquid nitrogen cryotherapy, marginal resection, and wide resection.

Consultations

An orthopedic oncologist should manage large or recurrent chondroblastomas.

Diet

No dietary restrictions are necessary.

Activity

Unless the lesion is particularly large and creates a risk of pathologic fracture, patients may participate in activity as tolerated. If an en bloc excision is performed, the patient's activity may be limited to protect the reconstruction.

Medication

No medical therapy is available or reported for chondroblastoma.

More on Chondroblastoma

Overview: Chondroblastoma
Differential Diagnoses & Workup: Chondroblastoma
Treatment & Medication: Chondroblastoma
Follow-up: Chondroblastoma
Multimedia: Chondroblastoma
References

References

  1. Codman EA. The classic: epiphyseal chondromatous giant cell tumors of the upper end of the humerus. Surg Gynecol Obstet.1931;52:543. Clin Orthop Relat Res. Sep 2006;450:12-6. [Medline].

  2. Jaffe HL, Lichtenstein L. Benign chondroblastoma of bone: a reinterpretation of the so-called calcifying or chondromatous giant cell tumor. Am J Pathol. 1942;18:969-91.

  3. Mii Y, Miyauchi Y, Morishita T, et al. Ultrastructural cytochemical demonstration of proteoglycans and calcium in the extracellular matrix of chondroblastomas. Hum Pathol. Dec 1994;25(12):1290-4. [Medline].

  4. Aigner T, Loos S, Inwards C, et al. Chondroblastoma is an osteoid-forming, but not cartilage-forming neoplasm. J Pathol. Dec 1999;189(4):463-9. [Medline].

  5. Brien EW, Mirra JM, Ippolito V. Chondroblastoma arising from a nonepiphyseal site. Skeletal Radiol. Apr 1995;24(3):220-2. [Medline].

  6. Turcotte RE, Kurt AM, Sim FH, et al. Chondroblastoma. Hum Pathol. Sep 1993;24(9):944-9. [Medline].

  7. Sjögren H, Orndal C, Tingby O, et al. Cytogenetic and spectral karyotype analyses of benign and malignant cartilage tumours. Int J Oncol. Jun 2004;24(6):1385-91. [Medline].

  8. Springfield DS, Capanna R, Gherlinzoni F, et al. Chondroblastoma. A review of seventy cases. J Bone Joint Surg Am. Jun 1985;67(5):748-55. [Medline].

  9. Kyriakos M, Land VJ, Penning HL, et al. Metastatic chondroblastoma. Report of a fatal case with a review of the literature on atypical, aggressive, and malignant chondroblastoma. Cancer. Apr 15 1985;55(8):1770-89. [Medline].

  10. Ostrowski ML, Johnson ME, Truong LD, et al. Malignant chondroblastoma presenting as a recurrent pelvic tumor with DNA aneuploidy and p53 mutation as supportive evidence of malignancy. Skeletal Radiol. Nov 1999;28(11):644-50. [Medline].

  11. Dahlin DC, Ivins JC. Benign chondroblastoma. A study of 125 cases. Cancer. Aug 1972;30(2):401-13. [Medline].

  12. Dorfman HD, Czerniak B. Cartilage Tumors. In: Bone Tumors. St Louis, Mo: Mosby; 1998:317.

  13. Fanning CV, Sneige NS, Carrasco CH, et al. Fine needle aspiration cytology of chondroblastoma of bone. Cancer. Apr 15 1990;65(8):1847-63. [Medline].

  14. Jambhekar NA, Desai PB, Chitale DA. Benign metastasizing chondroblastoma: a case report. Cancer. Feb 1998;82(4):675-8. [Medline].

  15. Jee WH, Park YK, McCauley TR, et al. Chondroblastoma: MR characteristics with pathologic correlation. J Comput Assist Tomogr. Sep-Oct 1999;23(5):721-6. [Medline].

  16. Khalili K, White LM, Kandel RA, et al. Chondroblastoma with multiple distant soft tissue metastases. Skeletal Radiol. Aug 1997;26(8):493-6. [Medline].

  17. Kurt AM, Turcotte RE, McLeod RA, et al. Chondroblastoma of bone. Orthopedics. Jul 1990;13(7):787-90. [Medline].

  18. Kurt AM, Unni KK, Sim FH, et al. Chondroblastoma of bone. Hum Pathol. Oct 1989;20(10):965-76. [Medline].

  19. Mermelstein LE, Friedlaender GE, Katz LD. Cystic chondroblastoma. Orthopedics. Jan 1997;20(1):69-71. [Medline].

  20. Mirra JM, Ulich TR, Eckardt JJ, et al. "Aggressive" chondroblastoma. Light and ultramicroscopic findings after en bloc resection. Clin Orthop Relat Res. Sep 1983;(178):276-84. [Medline].

  21. Pflueger P, Heinrich SD, Craver R. Chondroblastoma. Orthopedics. Mar 1993;16(3):339-42. [Medline].

  22. Ramappa AJ, Lee FY, Tang P, et al. Chondroblastoma of bone. J Bone Joint Surg Am. Aug 2000;82-A(8):1140-5. [Medline].

  23. Rodgers WB, Mankin HJ. Metastatic malignant chondroblastoma. Am J Orthop. Dec 1996;25(12):846-9. [Medline].

  24. Swarts SJ, Neff JR, Johansson SL, et al. Significance of abnormalities of chromosomes 5 and 8 in chondroblastoma. Clin Orthop Relat Res. Apr 1998;(349):189-93. [Medline].

  25. Weatherall PT, Maale GE, Mendelsohn DB, et al. Chondroblastoma: classic and confusing appearance at MR imaging. Radiology. Feb 1994;190(2):467-74. [Medline].

  26. Yamamura S, Sato K, Sugiura H, et al. Inflammatory reaction in chondroblastoma. Skeletal Radiol. May 1996;25(4):371-6. [Medline].

Further Reading

Keywords

CB, bone tumor, giant cell tumor, GCT, benign chondroblastoma, Codman's tumor, Codman tumor, bone-forming neoplasm, malignant chondroblastoma, aneurysmal bone cyst

Contributor Information and Disclosures

Author

Hannah D Morgan, MD, Consulting Staff, Connecticut Orthopaedic Specialists
Hannah D Morgan, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons and American Medical Association
Disclosure: Nothing to disclose.

Coauthor(s)

Timothy A Damron, MD, David G Murray Endowed Professor, Department of Orthopedic Surgery, Professor, Orthopedic Oncology and Adult Reconstruction, Vice Chair, Department of Orthopedics, State University of New York Upstate Medical University at Syracuse
Timothy A Damron, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American College of Surgeons, American Medical Association, Children's Oncology Group, Connective Tissue Oncology Society, Musculoskeletal Tumor Society, Orthopaedic Research Society, and Society for Experimental Biology and Medicine
Disclosure: Nothing to disclose.

Medical Editor

Howard A Chansky, MD, Associate Professor, Department of Orthopedics and Sports Medicine, University of Washington Medical Center
Howard A Chansky, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: Nothing to disclose.

Managing Editor

Sean P Scully, MD, PhD, Professor, Department of Orthopedics, University of Miami
Sean P Scully, MD, PhD is a member of the following medical societies: American Academy of Orthopaedic Surgeons, International Society on Thrombosis and Haemostasis, and Society of Surgical Oncology
Disclosure: Nothing to disclose.

CME Editor

Dinesh Patel, MD, FACS, Associate Clinical Professor of Orthopedic Surgery, Harvard Medical School; Chief of Arthroscopic Surgery, Department of Orthopedic Surgery, Massachusetts General Hospital
Dinesh Patel, MD, FACS is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American Association of Physicians of Indian Origin, American College of International Physicians, and American College of Surgeons
Disclosure: Nothing to disclose.

Chief Editor

Harris Gellman, MD, Consulting Surgeon, Broward Hand Center, Voluntary Clinical Professor of Orthopedic Surgery and Plastic Surgery, Departments of Orthopedic Surgery and Surgery, University of Miami School of Medicine
Harris Gellman, MD is a member of the following medical societies: American Academy of Medical Acupuncture, American Academy of Orthopaedic Surgeons, American Orthopaedic Association, American Society for Surgery of the Hand, and Arkansas Medical Society
Disclosure: Nothing to disclose.

RELATED MEDSCAPE ARTICLES
Articles
 
 
HONcode

We subscribe to the
HONcode principles of the
Health On the Net Foundation

All material on this website is protected by copyright, Copyright© 1994- by Medscape.
This website also contains material copyrighted by 3rd parties.

DISCLAIMER: The content of this Website is not influenced by sponsors. The site is designed primarily for use by qualified physicians and other medical professionals. The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for educational and informational purposes only. In no way should it be considered as offering medical advice. Please check with a physician if you suspect you are ill.