eMedicine Specialties > Orthopedic Surgery > Neoplasms

Chondromyxoid Fibroma: Follow-up

Author: Hannah D Morgan, MD, Consulting Staff, Connecticut Orthopaedic Specialists
Coauthor(s): Timothy A Damron, MD, David G Murray Endowed Professor, Department of Orthopedic Surgery, Professor, Orthopedic Oncology and Adult Reconstruction, Vice Chair, Department of Orthopedics, State University of New York Upstate Medical University at Syracuse
Contributor Information and Disclosures

Updated: Jan 18, 2008

Follow-up

Further Outpatient Care

  • The average time to recurrence is typically less than 2 years, but it has been reported to take up to 19 years after the initial tumor presentation.12,23,24,25 Patients should be monitored with periodic history and physical examinations and with routine radiographs of the affected site for a minimum of 2 years.

Complications

  • Arrest of growth may occur after aggressive curettage of tumors adjacent to the physis. Malignant transformation has been noted as a possible complication, even in the absence of preceding radiation therapy. However, many authors believe that cases of CMF that have been reported as malignant transformation have not been sufficiently documented and more likely represent a misdiagnosis of chondrosarcoma.

Prognosis

  • Patients are generally cured with en bloc excision and have an approximately 25% recurrence rate with usual treatment of curettage. In most cases, radiation therapy should be avoided because of its causative relationship with postradiation sarcoma. Occasional CMFs may be more aggressive, especially when they are located in the axial skeleton.
 


More on Chondromyxoid Fibroma

Overview: Chondromyxoid Fibroma
Differential Diagnoses & Workup: Chondromyxoid Fibroma
Treatment & Medication: Chondromyxoid Fibroma
Follow-up: Chondromyxoid Fibroma
Multimedia: Chondromyxoid Fibroma
References
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References

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  2. Ralph LL. Chondromyxoid fibroma of bone. J Bone and Joint Surg. 1962;44B(1):7-24.

  3. Schutt PG, Frost HM. Chondromyxoid fibroma. Clin Orthop Relat Res. 1971;78:323-9. [Medline].

  4. White PG, Saunders L, Orr W, et al. Chondromyxoid fibroma. Skeletal Radiol. Jan 1996;25(1):79-81. [Medline].

  5. Jaffe HL, Lichtenstein L. Chondromyxoid fibroma of bone: a distinctive benign tumor likely to be mistaken especially for chondrosarcoma. Arch Path. 1943;19:541-51.

  6. Baker AC, Rezeanu L, O'Laughlin S, et al. Juxtacortical chondromyxoid fibroma of bone: a unique variant: a case study of 20 patients. Am J Surg Pathol. Nov 2007;31(11):1662-8. [Medline].

  7. Romeo S, Oosting J, Rozeman LB, et al. The role of noncartilage-specific molecules in differentiation of cartilaginous tumors: lessons from chondroblastoma and chondromyxoid fibroma. Cancer. Jul 15 2007;110(2):385-94. [Medline].

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  10. Wu KK. Chondromyxoid fibroma of the foot bones. J Foot Ankle Surg. Sep-Oct 1995;34(5):513-9. [Medline].

  11. Granter SR, Renshaw AA, Kozakewich HP, et al. The pericentromeric inversion, inv (6)(p25q13), is a novel diagnostic marker in chondromyxoid fibroma. Mod Pathol. Nov 1998;11(11):1071-4. [Medline].

  12. Heydemann J, Gillespie R, Mancer K. Soft tissue recurrence of chondromyxoid fibroma. J Pediatr Orthop. Nov-Dec 1985;5(6):725-7. [Medline].

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  16. Marin C, Gallego C, Manjon P, et al. Juxtacortical chondromyxoid fibroma: imaging findings in three cases and a review of the literature. Skeletal Radiol. Nov 1997;26(11):642-9. [Medline].

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Further Reading

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Keywords

CMF, bone tumor, chondroblast, chondrosarcoma, benign tumor, aneurysmal bone cyst

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Contributor Information and Disclosures

Author

Hannah D Morgan, MD, Consulting Staff, Connecticut Orthopaedic Specialists
Hannah D Morgan, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons and American Medical Association
Disclosure: Nothing to disclose.

Coauthor(s)

Timothy A Damron, MD, David G Murray Endowed Professor, Department of Orthopedic Surgery, Professor, Orthopedic Oncology and Adult Reconstruction, Vice Chair, Department of Orthopedics, State University of New York Upstate Medical University at Syracuse
Timothy A Damron, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American College of Surgeons, American Medical Association, Children's Oncology Group, Connective Tissue Oncology Society, Musculoskeletal Tumor Society, Orthopaedic Research Society, and Society for Experimental Biology and Medicine
Disclosure: Nothing to disclose.

Medical Editor

Howard A Chansky, MD, Associate Professor, Department of Orthopedics and Sports Medicine, University of Washington Medical Center
Howard A Chansky, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: Nothing to disclose.

CME Editor

Dinesh Patel, MD, FACS, Associate Clinical Professor of Orthopedic Surgery, Harvard Medical School; Chief of Arthroscopic Surgery, Department of Orthopedic Surgery, Massachusetts General Hospital
Dinesh Patel, MD, FACS is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American Association of Physicians of Indian Origin, American College of International Physicians, and American College of Surgeons
Disclosure: Nothing to disclose.

Chief Editor

Harris Gellman, MD, Consulting Surgeon, Broward Hand Center, Voluntary Clinical Professor of Orthopedic Surgery and Plastic Surgery, Departments of Orthopedic Surgery and Surgery, University of Miami School of Medicine
Harris Gellman, MD is a member of the following medical societies: American Academy of Medical Acupuncture, American Academy of Orthopaedic Surgeons, American Orthopaedic Association, American Society for Surgery of the Hand, and Arkansas Medical Society
Disclosure: Nothing to disclose.

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