Chondromyxoid Fibroma Medication
- Author: Hannah D Morgan, MD; Chief Editor: Harris Gellman, MD more...
Medication Summary
Nonsteroidal anti-inflammatory agents or analgesics may be used for pain control.
Nonsteroidal anti-inflammatory drugs (NSAIDs)
Class Summary
NSAIDs have analgesic, anti-inflammatory, and antipyretic activities. Their mechanism of action is not known, but they may inhibit cyclo-oxygenase activity and prostaglandin synthesis. Other mechanisms may exist as well, such as inhibition of leukotriene synthesis, lysosomal enzyme release, lipoxygenase activity, neutrophil aggregation, and various cell membrane functions.
Ibuprofen (Motrin, Ibuprin)
DOC for patients with mild to moderate pain. Ibuprofen inhibits inflammatory reactions and pain by decreasing prostaglandin synthesis.
Naproxen (Naprosyn, Anaprox, Aleve, Naprelan)
Used for the relief of mild to moderate pain. Inhibits inflammatory reactions and pain by decreasing the activity of cyclo-oxygenase, which results in decreased prostaglandin synthesis.
Ketoprofen (Actron, Orudis, Oruvail)
Used for the relief of mild to moderate pain and inflammation. Small dosages are initially indicated in small and elderly patients and in persons with renal or liver disease. Doses >75 mg do not increase the therapeutic effects. Administer high doses with caution and closely observe the patient for his/her response.
Analgesics
Class Summary
Pain control is essential to quality patient care. Analgesics ensure patient comfort and have sedating properties, which are beneficial for patients who experience pain.
Acetaminophen (Aspirin Free Anacin, Tylenol, FeverAll, Tempra)
DOC for pain in patients with documented hypersensitivity to aspirin or NSAIDs, with upper GI disease, or who are taking oral anticoagulants.
Hydrocodone and acetaminophen (Lorcet-HP, Lortab, Norcet, Vicodin)
This drug combination is indicated for moderate to severe pain.
McGrory BJ, Inwards CY, McLeod RA, et al. Chondromyxoid fibroma. Orthopedics. Mar 1995;18(3):307-10. [Medline].
Ralph LL. Chondromyxoid fibroma of bone. J Bone and Joint Surg. 1962;44B(1):7-24.
Schutt PG, Frost HM. Chondromyxoid fibroma. Clin Orthop Relat Res. 1971;78:323-9. [Medline].
White PG, Saunders L, Orr W, et al. Chondromyxoid fibroma. Skeletal Radiol. Jan 1996;25(1):79-81. [Medline].
Jaffe HL, Lichtenstein L. Chondromyxoid fibroma of bone: a distinctive benign tumor likely to be mistaken especially for chondrosarcoma. Arch Path. 1943;19:541-51.
Baker AC, Rezeanu L, O'Laughlin S, et al. Juxtacortical chondromyxoid fibroma of bone: a unique variant: a case study of 20 patients. Am J Surg Pathol. Nov 2007;31(11):1662-8. [Medline].
Romeo S, Hogendoorn PC, Dei Tos AP. Benign cartilaginous tumors of bone: from morphology to somatic and germ-line genetics. Adv Anat Pathol. Sep 2009;16(5):307-15. [Medline].
Romeo S, Oosting J, Rozeman LB, et al. The role of noncartilage-specific molecules in differentiation of cartilaginous tumors: lessons from chondroblastoma and chondromyxoid fibroma. Cancer. Jul 15 2007;110(2):385-94. [Medline].
Blackwell JB, Norma M, Curnow P. Benign bone tumours in Western Australia, 1972-1996. Pathology. Dec 2007;39(6):567-74. [Medline].
Wu CT, Inwards CY, O''Laughlin S, et al. Chondromyxoid fibroma of bone: a clinicopathologic review of 278 cases. Hum Pathol. May 1998;29(5):438-46. [Medline].
Wu KK. Chondromyxoid fibroma of the foot bones. J Foot Ankle Surg. Sep-Oct 1995;34(5):513-9. [Medline].
Granter SR, Renshaw AA, Kozakewich HP, et al. The pericentromeric inversion, inv (6)(p25q13), is a novel diagnostic marker in chondromyxoid fibroma. Mod Pathol. Nov 1998;11(11):1071-4. [Medline].
Yasuda T, Nishio J, Sumegi J, Kapels KM, Althof PA, Sawyer JR, et al. Aberrations of 6q13 mapped to the COL12A1 locus in chondromyxoid fibroma. Mod Pathol. Nov 2009;22(11):1499-506. [Medline].
Heydemann J, Gillespie R, Mancer K. Soft tissue recurrence of chondromyxoid fibroma. J Pediatr Orthop. Nov-Dec 1985;5(6):725-7. [Medline].
Kyriakos M. Soft tissue implantation of chondromyxoid fibroma. Am J Surg Pathol. Aug 1979;3(4):363-72. [Medline].
Dahlin DC. Chondromyxoid fibroma of bone, with emphasis on its morphological relationship to benign chondroblastoma. Cancer. Jan-Feb 1956;9(1):195-203. [Medline].
Sakayama K, Sugawara Y, Kidani T, et al. Diagnostic and therapeutic problems of giant cell tumor in the proximal femur. Arch Orthop Trauma Surg. Dec 2007;127(10):867-72. [Medline].
Marin C, Gallego C, Manjon P, et al. Juxtacortical chondromyxoid fibroma: imaging findings in three cases and a review of the literature. Skeletal Radiol. Nov 1997;26(11):642-9. [Medline].
Merine D, Fishman EK, Rosengard A, et al. Chondromyxoid fibroma of the fibula. J Pediatr Orthop. Jul-Aug 1989;9(4):468-71. [Medline].
Yamaguchi T, Dorfman HD. Radiographic and histologic patterns of calcification in chondromyxoid fibroma. Skeletal Radiol. Oct 1998;27(10):559-64. [Medline].
Cabral CE, Romano S, Guedes P, et al. Chondromyxoid fibroma of the lumbar spine. Skeletal Radiol. Aug 1997;26(8):488-92. [Medline].
Murata H, Horie N, Matsui T, Akai T, Ueda H, Oshima Y, et al. Clinical usefulness of thallium-201 scintigraphy and magnetic resonance imaging in the diagnosis of chondromyxoid fibroma. Ann Nucl Med. Apr 2008;22(3):221-4. [Medline].
Bergman S, Madden CR, Geisinger KR. Fine-needle aspiration biopsy of chondromyxoid fibroma: an investigation of four cases. Am J Clin Pathol. Nov 2009;132(5):740-5. [Medline].
Nielsen GP, Keel SB, Dickersin GR, et al. Chondromyxoid fibroma: a tumor showing myofibroblastic, myochondroblastic, and chondrocytic differentiation. Mod Pathol. May 1999;12(5):514-7. [Medline].
Konishi E, Nakashima Y, Iwasa Y, Nakao R, Yanagisawa A. Immunohistochemical analysis for Sox9 reveals the cartilaginous character of chondroblastoma and chondromyxoid fibroma of the bone. Hum Pathol. Oct 2 2009;[Medline].
Durr HR, Lienemann A, Nerlich A, et al. Chondromyxoid fibroma of bone. Arch Orthop Trauma Surg. 2000;120(1-2):42-7. [Medline].
Hristov B, Shokek O, Frassica DA. The role of radiation treatment in the contemporary management of bone tumors. J Natl Compr Canc Netw. Apr 2007;5(4):456-66. [Medline].
Gherlinzoni F, Rock M, Picci P. Chondromyxoid fibroma. The experience at the Istituto Ortopedico Rizzoli. J Bone Joint Surg Am. Feb 1983;65(2):198-204. [Medline].
Mikulowski P, Ostberg G. Recurrent chondromyxoid fibroma. Acta Orthop Scand. 1971;42(5):385-90. [Medline].
Zillmer DA, Dorfman HD. Chondromyxoid fibroma of bone: thirty-six cases with clinicopathologic correlation. Hum Pathol. Oct 1989;20(10):952-64. [Medline].

