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Vitamin E Deficiency Follow-up

  • Author: Gary E Caplan, MD, MPH, FACOEM; Chief Editor: George T Griffing, MD  more...
 
Updated: Sep 06, 2013
 

Deterrence/Prevention

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  • Vitamin E overdose is difficult to achieve and, thus, is extremely uncommon.
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Patient Education

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  • Vitamin E has been used as a preventive agent for heart disease[20] ; however, this use has not been approved by the FDA.
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Contributor Information and Disclosures
Author

Gary E Caplan, MD, MPH, FACOEM Occupational Medicine Physician, Workers Compensation Consultant, Healthlink

Gary E Caplan, MD, MPH, FACOEM is a member of the following medical societies: American College of Preventive Medicine, American College of Occupational and Environmental Medicine

Disclosure: Nothing to disclose.

Specialty Editor Board

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Romesh Khardori, MD, PhD, FACP Professor of Endocrinology, Director of Training Program, Division of Endocrinology, Diabetes and Metabolism, Strelitz Diabetes and Endocrine Disorders Institute, Department of Internal Medicine, Eastern Virginia Medical School

Romesh Khardori, MD, PhD, FACP is a member of the following medical societies: American Association of Clinical Endocrinologists, American College of Physicians, American Diabetes Association, Endocrine Society

Disclosure: Nothing to disclose.

Chief Editor

George T Griffing, MD Professor Emeritus of Medicine, St Louis University School of Medicine

George T Griffing, MD is a member of the following medical societies: American Association for the Advancement of Science, International Society for Clinical Densitometry, Southern Society for Clinical Investigation, American College of Medical Practice Executives, American Association for Physician Leadership, American College of Physicians, American Diabetes Association, American Federation for Medical Research, American Heart Association, Central Society for Clinical and Translational Research, Endocrine Society

Disclosure: Nothing to disclose.

References
  1. Benomar A, Yahyaoui M, Marzouki N, et al. Vitamin E deficiency ataxia associated with adenoma. J Neurol Sci. 1999 Jan 1. 162(1):97-101. [Medline].

  2. Sokol RJ. Vitamin E and neurologic deficits. Adv Pediatr. 1990. 37:119-48. [Medline].

  3. Sokol RJ, Guggenheim MA, Heubi JE, et al. Frequency and clinical progression of the vitamin E deficiency neurologic disorder in children with prolonged neonatal cholestasis. Am J Dis Child. 1985 Dec. 139(12):1211-5. [Medline].

  4. Tanyel MC, Mancano LD. Neurologic findings in vitamin E deficiency. Am Fam Physician. 1997 Jan. 55(1):197-201. [Medline].

  5. Rino Y, Suzuki Y, Kuroiwa Y, et al. Vitamin E malabsorption and neurological consequences after gastrectomy for gastric cancer. Hepatogastroenterology. 2007 Sep. 54(78):1858-61. [Medline].

  6. Fuller CJ, Huet BA, Jialal I. Effects of increasing doses of alpha-tocopherol in providing protection of low-density lipoprotein from oxidation. Am J Cardiol. 1998 Jan 15. 81(2):231-3. [Medline].

  7. Hathcock JN. Vitamins and minerals: efficacy and safety. Am J Clin Nutr. 1997 Aug. 66(2):427-37. [Medline]. [Full Text].

  8. Traber MG, Frei B, Beckman JS. Vitamin E revisited: do new data validate benefits for chronic disease prevention?. Curr Opin Lipidol. 2008 Feb. 19(1):30-8. [Medline].

  9. Stephens NG, Parsons A, Schofield PM, et al. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). Lancet. 1996 Mar 23. 347(9004):781-6. [Medline].

  10. Yusuf S, Dagenais G, Pogue J, et al. Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med. 2000 Jan 20. 342(3):154-60. [Medline]. [Full Text].

  11. Pekmezci D. Vitamin E and immunity. Vitam Horm. 2011. 86:179-215. [Medline].

  12. Traber MG, Stevens JF. Vitamins C and E: beneficial effects from a mechanistic perspective. Free Radic Biol Med. 2011 Sep 1. 51(5):1000-13. [Medline]. [Full Text].

  13. Morley S, Cecchini M, Zhang W, et al. Mechanisms of ligand transfer by the hepatic tocopherol transfer protein. J Biol Chem. 2008 Jun 27. 283(26):17797-804. [Medline].

  14. Jayadev S, Bird TD. Hereditary ataxias: overview. Genet Med. 2013 Mar 28. [Medline].

  15. Rossato M, Mariotti C. Normal spermatogenesis and sperm function in a subject affected by cerebellar ataxia due to congenital vitamin E deficiency. Andrologia. 2013 Feb 28. [Medline].

  16. Bromley D, Anderson PC, Daggett V. Structural consequences of mutations to the a-tocopherol transfer protein associated with the neurodegenerative disease ataxia with vitamin E deficiency. Biochemistry. 2013 Jun 18. 52(24):4264-73. [Medline]. [Full Text].

  17. Steinraths M, Vallance HD, Davidson AG. Delays in diagnosing cystic fibrosis: can we find ways to diagnose it earlier?. Can Fam Physician. 2008 Jun. 54(6):877-83. [Medline].

  18. Virtamo J, Rapola JM, Ripatti S, et al. Effect of vitamin E and beta carotene on the incidence of primary nonfatal myocardial infarction and fatal coronary heart disease. Arch Intern Med. 1998 Mar 23. 158(6):668-75. [Medline]. [Full Text].

  19. Kono N, Ohto U, Hiramatsu T, Urabe M, Uchida Y, Satow Y, et al. Impaired a-TTP-PIPs interaction underlies familial vitamin E deficiency. Science. 2013 May 31. 340(6136):1106-10. [Medline].

  20. Das SK, Gupta G, Rao DN, et al. Effect of lecithin with vitamin-B complex and tocopheryl acetate on long-term effect of ethanol induced immunomodulatory activities. Indian J Exp Biol. 2007 Aug. 45(8):683-8. [Medline].

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Comparison of the recommended daily allowance (RDA), deficiency replacement dose, and preventive dose in international units (IUs) and milligrams.
 
 
 
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