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Vitamin E Deficiency Medication

  • Author: Gary E Caplan, MD, MPH, FACOEM; Chief Editor: George T Griffing, MD  more...
 
Updated: Sep 06, 2013
 

Medication Summary

Comparison of the recommended daily allowance (RDA), deficiency replacement dose, and preventive dose in international units (IUs) and milligrams is shown in the image below.

Comparison of the recommended daily allowance (RDA Comparison of the recommended daily allowance (RDA), deficiency replacement dose, and preventive dose in international units (IUs) and milligrams.

The RDA of alpha tocopherol according to age is as follows:

  • Age 0-6 months - 3 mg
  • Age 6-12 months - 4 mg
  • Age 1-3 years - 6 mg
  • Age 4-10 years - 7 mg
  • Adults and elderly individuals - 8-10 mg

Prevention

Vitamin E supplementation is important, because apparently effective doses are beyond the maximum dietary intake. Supplementation with vitamin E is extremely safe except when normal coagulation mechanisms are impaired.

Replacement recommendations according to disease state are as follows:

  • Abetalipoproteinemia - 100-200 IU/kg/d
  • Chronic cholestasis - 15-25 IU/kg/d
  • Cystic fibrosis - 5-10 IU/kg/d
  • Short-bowel syndrome - 200-3600 IU/d
  • Isolated vitamin E deficiency - 800-3600 IU/d

Larger doses are required in short-bowel syndrome and isolated vitamin E deficiency state.

Pregnancy/lactation

Vitamin E is in the Food and Drug Administration's (FDA's) pregnancy category A. Breastfeeding is safe.

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Vitamins

Class Summary

Essential for normal cell function.

Vitamin E (alpha tocopherol)

 

Protects cell membranes from free radical attacks.

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Contributor Information and Disclosures
Author

Gary E Caplan, MD, MPH, FACOEM Occupational Medicine Physician, Workers Compensation Consultant, Healthlink

Gary E Caplan, MD, MPH, FACOEM is a member of the following medical societies: American College of Preventive Medicine, American College of Occupational and Environmental Medicine

Disclosure: Nothing to disclose.

Specialty Editor Board

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Romesh Khardori, MD, PhD, FACP Professor of Endocrinology, Director of Training Program, Division of Endocrinology, Diabetes and Metabolism, Strelitz Diabetes and Endocrine Disorders Institute, Department of Internal Medicine, Eastern Virginia Medical School

Romesh Khardori, MD, PhD, FACP is a member of the following medical societies: American Association of Clinical Endocrinologists, American College of Physicians, American Diabetes Association, Endocrine Society

Disclosure: Nothing to disclose.

Chief Editor

George T Griffing, MD Professor Emeritus of Medicine, St Louis University School of Medicine

George T Griffing, MD is a member of the following medical societies: American Association for the Advancement of Science, International Society for Clinical Densitometry, Southern Society for Clinical Investigation, American College of Medical Practice Executives, American Association for Physician Leadership, American College of Physicians, American Diabetes Association, American Federation for Medical Research, American Heart Association, Central Society for Clinical and Translational Research, Endocrine Society

Disclosure: Nothing to disclose.

References
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  16. Bromley D, Anderson PC, Daggett V. Structural consequences of mutations to the a-tocopherol transfer protein associated with the neurodegenerative disease ataxia with vitamin E deficiency. Biochemistry. 2013 Jun 18. 52(24):4264-73. [Medline]. [Full Text].

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  18. Virtamo J, Rapola JM, Ripatti S, et al. Effect of vitamin E and beta carotene on the incidence of primary nonfatal myocardial infarction and fatal coronary heart disease. Arch Intern Med. 1998 Mar 23. 158(6):668-75. [Medline]. [Full Text].

  19. Kono N, Ohto U, Hiramatsu T, Urabe M, Uchida Y, Satow Y, et al. Impaired a-TTP-PIPs interaction underlies familial vitamin E deficiency. Science. 2013 May 31. 340(6136):1106-10. [Medline].

  20. Das SK, Gupta G, Rao DN, et al. Effect of lecithin with vitamin-B complex and tocopheryl acetate on long-term effect of ethanol induced immunomodulatory activities. Indian J Exp Biol. 2007 Aug. 45(8):683-8. [Medline].

 
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Comparison of the recommended daily allowance (RDA), deficiency replacement dose, and preventive dose in international units (IUs) and milligrams.
 
 
 
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