eMedicine Specialties > Endocrinology > Metabolic Disorders

Hypertriglyceridemia: Multimedia

Author: Elena Citkowitz, MD, PhD, FACP, Clinical Professor of Medicine, Yale University School of Medicine; Director, Cholesterol Management Center, Director, Cardiac Rehabilitation, Department of Medicine, Hospital of St Raphael
Contributor Information and Disclosures

Updated: Jul 12, 2008

Multimedia

Eruptive xanthomas on the back of a patient admit...Media file 1: Eruptive xanthomas on the back of a patient admitted with a triglyceride level of 4600 mg/dL and acute pancreatitis.
Eruptive xanthomas on the back of a patient admit...

Eruptive xanthomas on the back of a patient admitted with a triglyceride level of 4600 mg/dL and acute pancreatitis.

Close-up of eruptive xanthomas from Media file 1.Media file 2: Close-up of eruptive xanthomas from Media file 1.
Close-up of eruptive xanthomas from Media file 1.

Close-up of eruptive xanthomas from Media file 1.

Composition of triglyceride-rich lipoproteins.Media file 3: Composition of triglyceride-rich lipoproteins.
Composition of triglyceride-rich lipoproteins.

Composition of triglyceride-rich lipoproteins.

More on Hypertriglyceridemia

Overview: Hypertriglyceridemia
Differential Diagnoses & Workup: Hypertriglyceridemia
Treatment & Medication: Hypertriglyceridemia
Follow-up: Hypertriglyceridemia
Multimedia: Hypertriglyceridemia
References

References

  1. Fredrickson DS, Lees RS. A system for phenotyping hyperlipidaemia. Circulation. Mar 1965;31:321-7. [Medline].

  2. National Cholesterol Education Program. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. May 16 2001;285(19):2486-97. [Medline].

  3. Brunzell JD, Bierman EL. Chylomicronemia syndrome. Interaction of genetic and acquired hypertriglyceridemia. Med Clin North Am. Mar 1982;66:455-68. [Medline].

  4. Chait A, Brunzell JD. Chylomicronemia syndrome. Adv Intern Med. 1992;37:249-73. [Medline].

  5. Assmann G, Schulte H. Relation of high-density lipoprotein cholesterol and triglycerides to incidence of atherosclerotic coronary artery disease (the PROCAM experience). Prospective Cardiovascular Munster study. Am J Cardiol. Sep 15 1992;70(7):733-7. [Medline].

  6. Fortson MR, Freedman SN, Webster PD 3rd. Clinical assessment of hyperlipidemic pancreatitis. Am J Gastroenterol. Dec 1995;90(12):2134-9. [Medline].

  7. Haffner SM. Secondary prevention of coronary heart disease: the role of fibric acids [editorial; comment]. Circulation. Jul 4 2000;102(1):2-4. [Medline].

  8. Bezafibrate Infarction Prevention Study. Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease: the Bezafibrate Infarction Prevention (BIP) study. Circulation. Jul 4 2000;102(1):21-7. [Medline].

  9. Manninen V, Elo MO, Frick MH. Lipid alterations and decline in the incidence of coronary heart disease in the Helsinki Heart Study. JAMA. Aug 5 1988;260(5):641-51. [Medline].

  10. Rizos E, Mikhailidis DP. Are high-density lipoprotein and triglyceride levels important in secondary prevention: impressions from the BIP and VA-HIT trials. Int J Cardiol. Mar 2002;82(3):199-207; discussion 207-8. [Medline].

  11. McKenney JM, McCormick LS, Weiss S. A randomized trial of the effects of atorvastatin and niacin in patients with combined hyperlipidemia or isolated hypertriglyceridemia. Collaborative Atorvastatin Study Group. Am J Med. Feb 1998;104(2):137-43. [Medline].

  12. Athyros VG, Giouleme OI, Nikolaidis NL. Long-term follow-up of patients with acute hypertriglyceridemia-induced pancreatitis. J Clin Gastroenterol. Apr 2002;34(4):472-5. [Medline].

  13. Hsia SH, Connelly PW, Hegele RA. Successful outcome in severe pregnancy-associated hyperlipemia: a case report and literature review. Am J Med Sci. Apr 1995;309(4):213-8. [Medline].

  14. Ahmed SM, Clasen ME, Donnelly JE. Management of dyslipidemia in adults. Am Fam Physician. May 1 1998;57(9):2192-2204, 2207-8. [Medline].

  15. Austin MA. Plasma triglyceride as a risk factor for coronary heart disease. The epidemiologic evidence and beyond. Am J Epidemiol. Feb 1989;129(2):249-59. [Medline].

  16. Bainton D, Miller NE, Bolton CH. Plasma triglyceride and high density lipoprotein cholesterol as predictors of ischaemic heart disease in British men. The Caerphilly and Speedwell Collaborative Heart Disease Studies. Br Heart J. Jul 1992;68(1):60-6. [Medline].

  17. Bamba V, Rader DJ. Obesity and atherogenic dyslipidemia. Gastroenterology. May 2007;132(6):2181-90. [Medline][Full Text].

  18. Bierman EL, Brunzell JD. Diet low in saturated fat and cholesterol for diabetes. Diabetes Care. Feb 1989;12(2):162-3. [Medline].

  19. Brunzell JD. Clinical practice. Hypertriglyceridemia. N Engl J Med. Sep 6 2007;357(10):1009-17. [Medline].

  20. Davignon J, Roederer G, Montigny M. Comparative efficacy and safety of pravastatin, nicotinic acid and the two combined in patients with hypercholesterolemia. Am J Cardiol. Feb 15 1994;73(5):339-45. [Medline].

  21. Diabetes Atherosclerosis Intervention Study. Effect of fenofibrate on progression of coronary-artery disease in type 2 diabetes: the Diabetes Atherosclerosis Intervention Study, a randomised study. Lancet. Mar 24 2001;357(9260):905-10. [Medline].

  22. Fruchart JC, Brewer HB Jr, Leitersdorf E. Consensus for the use of fibrates in the treatment of dyslipoproteinemia and coronary heart disease. Fibrate Consensus Group. Am J Cardiol. Apr 1 1998;81(7):912-7. [Medline].

  23. Glueck CJ, Oakes N, Speirs J. Gemfibrozil-lovastatin therapy for primary hyperlipoproteinemias. Am J Cardiol. Jul 1 1992;70(1):1-9. [Medline].

  24. Haim M, Benderly M, Brunner D. Elevated serum triglyceride levels and long-term mortality in patients with coronary heart disease: the Bezafibrate Infarction Prevention (BIP) Registry. Circulation. Aug 3 1999;100(5):475-82. [Medline].

  25. Havel RJ and Guyton JP. Introduction: Structure and Metabolism of Plasma Lipoproteins. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. Metabolic and Molecular Bases of Inherited Disease. 3. 8th ed. New York, NY: McGraw-Hill; 2001:114. [Full Text].

  26. Jacobson TA, Miller M, Schaefer EJ. Hypertriglyceridemia and cardiovascular risk reduction. Clin Ther. May 2007;29(5):763-77. [Medline].

  27. Jacobson TA, Miller M, Schaefer EJ. Hypertriglyceridemia and cardiovascular risk reduction. Clin Ther. May 2007;29(5):763-77. [Medline].

  28. Manninen V, Tenkanen L, Koskinen P. Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study. Implications for treatment. Circulation. Jan 1992;85(1):37-45. [Medline].

  29. Margolis S, Dobs AS. Nutritional management of plasma lipid disorders. J Am Coll Nutr. 1989;8:Suppl: 33S-45S. [Medline].

  30. McKenney JM, Proctor JD, Harris S. A comparison of the efficacy and toxic effects of sustained- vs immediate-release niacin in hypercholesterolemic patients. JAMA. Mar 2 1994;271(9):672-7. [Medline].

  31. Rader DJ, Rosas S. Management of selected lipid abnormalities. Hypertriglyceridemia, low HDL cholesterol, lipoprotein(a), in thyroid and renal diseases, and post-transplantation. Med Clin North Am. Jan 2000;84(1):43-61. [Medline].

  32. Rubins HB, Robins SJ, Collins D. Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. N Engl J Med. Aug 5 1999;341(6):410-8. [Medline].

  33. Sanderson SL, Iverius PH, Wilson DE. Successful hyperlipemic pregnancy. JAMA. Apr 10 1991;265(14):1858-60. [Medline].

  34. Shepherd J. Fibrates and statins in the treatment of hyperlipidaemia: an appraisal of their efficacy and safety. Eur Heart J. Jan 1995;16(1):5-13. [Medline].

  35. Wagner AM, Jorba O, Bonet R. Efficacy of atorvastatin and gemfibrozil, alone and in low dose combination, in the treatment of diabetic dyslipidemia. J Clin Endocrinol Metab. Jul 2003;88(7):3212-7. [Medline].

  36. Wiklund O, Angelin B, Bergman M. Pravastatin and gemfibrozil alone and in combination for the treatment of hypercholesterolemia. Am J Med. Jan 1993;94(1):13-20. [Medline].

Further Reading

Keywords

hTG, chylomicronemia, dysbetalipoproteinemia, familial combined hyperlipoproteinemia, hyperlipidemia, hyperlipoproteinemia, mixed hyperlipidemia, type I hyperlipoproteinemia, type IIb hyperlipoproteinemia, type III hyperlipoproteinemia, type IV hyperlipoproteinemia, type V hyperlipoproteinemia, triglycerides, diabetes mellitus, DM, coronary artery disease, CAD, cardiovascular disease, CVD

Contributor Information and Disclosures

Author

Elena Citkowitz, MD, PhD, FACP, Clinical Professor of Medicine, Yale University School of Medicine; Director, Cholesterol Management Center, Director, Cardiac Rehabilitation, Department of Medicine, Hospital of St Raphael
Elena Citkowitz, MD, PhD, FACP is a member of the following medical societies: American College of Physicians, American Heart Association, National Lipid Association, and Sigma Xi
Disclosure: Nothing to disclose.

Medical Editor

Steven R Gambert, MD, Program Director, Physician-in-Chief, Professor, Department of Internal Medicine, Sinai Hospital, Johns Hopkins University School of Medicine
Steven R Gambert, MD is a member of the following medical societies: American College of Physicians
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: Nothing to disclose.

Managing Editor

Yoram Shenker, MD, Chief of Endocrinology Section, Veterans Affairs Medical Center of Madison; Interim Chief, Associate Professor, Department of Internal Medicine, Section of Endocrinology, Diabetes and Metabolism, University of Wisconsin at Madison
Yoram Shenker, MD is a member of the following medical societies: American Heart Association, Central Society for Clinical Research, and Endocrine Society
Disclosure: Nothing to disclose.

CME Editor

Mark Cooper, MBBS, PhD, FRACP, Head, Diabetes & Metabolism Division, Baker Heart Research Institute, Professor of Medicine, Monash University
Disclosure: Nothing to disclose.

Chief Editor

George T Griffing, MD, Professor of Medicine, St Louis University School of Medicine
George T Griffing, MD is a member of the following medical societies: American Association for the Advancement of Science, American College of Medical Practice Executives, American College of Physician Executives, American College of Physicians, American Diabetes Association, American Federation for Medical Research, American Heart Association, Central Society for Clinical Research, Endocrine Society, International Society for Clinical Densitometry, and Southern Society for Clinical Investigation
Disclosure: Nothing to disclose.

 
 
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