Growth Hormone Replacement in Older Men Clinical Presentation
- Author: Angela Gentili, MD; Chief Editor: George T Griffing, MD more...
GHD in adults causes changes in body composition that are similar to those occurring with normal aging, such as the following:
- Decrease in lean body mass
- Increase in total and abdominal fat
- Decrease in muscle strength
- Decrease in bone mineral density
The pathophysiology of somatopause is confounded by several variables that can contribute to the decline in GH secretion associated with aging: adiposity, decreased production of sex steroid hormones, decreased physical fitness, fragmented sleep, and malnutrition (see Pathophysiology).
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