Updated: Jul 7, 2009
Breast reconstruction entered the modern era when Hartrampf, Scheflan, and Black introduced the transverse rectus abdominis myocutaneous (TRAM) flap in 1982.1 This ingenious procedure reliably transfers autogenous tissue for reconstruction and has the added benefit of abdominal rejuvenation. The TRAM flap has proven to be the autogenous tissue of choice for breast reconstruction.
The main advantage of the procedure lies in the consistency of the reconstructed breast; it is similar to the natural breast in softness and in the way the tissue drapes on the chest. Because the tissue is part of the patient's body, it does not incite foreign-body reaction or capsular contractures, which have plagued implant reconstructions. Furthermore, since scars fade and tissues soften, the reconstruction only improves over time, which is not true of implant reconstructions.
Since the inception of the TRAM flap, surgeons have developed different methods to improve blood supply to the transferred abdominal tissues. These methods currently include use of a midabdominal TRAM flap, a bipedicled TRAM flap, a microvascular augmentation (supercharge) of a unipedicled TRAM flap, a "delay" of a unipedicled TRAM flap,2 and a free-tissue transfer (or free) TRAM flap, which includes perforator flaps. Of these procedures, only the free TRAM flap takes full advantage of the primary blood supply (inferior epigastric blood vessels) of the TRAM flap tissues. This technique completely removes the abdominal tissues from the body and transplants them to the chest area.
This procedure now accounts for approximately 20% of breast reconstructions performed in the United States.
Consider free TRAM flap reconstruction for any patient undergoing mastectomy, either as an immediate procedure (at the time of mastectomy) or as a delayed procedure (some time after mastectomy). Simultaneous bilateral breast reconstruction may be performed with 2 free TRAM flaps. The patient must be psychologically motivated and have adequate tissues in the abdominal area to be considered for a free TRAM flap. Implant reconstruction and tissue reconstruction may be considered for any patient, though the following relative indications favor the free TRAM flap procedure.
The flap skin and fat of a free TRAM flap reconstruction survive on perforators through the rectus abdominis muscle. Although this muscle has a dual blood supply (ie, the superior and inferior epigastric arteries), this operation relies only on the inferior epigastric arterial system. Since this is the primary blood supply of these tissues, excellent vascularity is noted over most of the TRAM flap, even in tissue not directly adjacent to the muscle perforators. Only a small cuff of rectus abdominis muscle is harvested with the flap, thereby limiting dissection of the abdominal wall and postoperative discomfort.
In patients with favorable anatomy, all muscle can be preserved and only the perforating vessels are taken with the flap (so-called perforator flaps). If the primary vessels used are the deep inferior epigastric artery and vein, the flap is called a deep inferior epigastric perforator (DIEP) flap.5 If the primary vessels used are the superficial inferior epigastric artery and vein, the flap is called a superficial inferior epigastric perforator (SIEP) flap.
Because ultimate abdominal discomfort and function can be similar for patients after operations involving traditional free TRAM flaps and perforator flaps, some microsurgeons do not believe the added operative time and risk of dissecting only the perforators are indicated. However, data suggest less abdominal morbidity and lower requirements for pain management for the perforator flap patient. In the final analysis, the type of free-tissue transfer performed depends on the patient's desires and anatomy and the surgeon's experience and preference.5,6,7
The free TRAM flap operation is major surgery and should not be undertaken lightly by the patient or surgeon. Fifteen years' experience with these procedures enables the author to identify the following characteristics that place patients at higher risk for complications:
Because of the magnitude of the procedure and the degree of stress on the lungs and heart, this operation may unmask baseline cardiopulmonary disease and result in a complicated postoperative course. In addition, anything that causes small-vessel disease, such as the medical conditions listed above or cigarette smoking, may cause complications in the transferred tissue and in the abdominal donor site. Any of the above characteristics contraindicate a TRAM flap procedure; in such cases, the surgeon should seek another method of reconstruction.
Multiple procedures are required for a successful free TRAM flap breast reconstruction.
Stage I - TRAM flap
This may be performed at mastectomy or afterward. If irradiation of the chest is planned, delaying the TRAM flap procedure is recommended in order to limit scarring and deformity of the flap from radiation injury, a phenomenon that has been documented even years later. Belly tissues are used to create the breast mound, and this stage may include a procedure on the opposite breast for optimal symmetry. The operation may last from 4-8 hours. Unlike with pedicled TRAM flaps, the surgeon must spend time finding recipient vessels, which usually involve the thoracodorsal, axillary, circumflex scapular, internal mammary, or thoracoacromial systems. Occasionally, vein grafts are necessary. During this procedure, 90% of the reconstructive work is performed.
Stage II - Revisions and nipple reconstruction
Approximately 3-4 months after the TRAM flap procedure, tissues settle enough and scar tissue relaxes sufficient to allow small revisions and reconstruction of the nipple. Often, these procedures can be performed in an office setting. Chemotherapy should be completed with a 4- to 6-week additional waiting period before further surgery.
Radiation therapy may result in an additional delay of 6 months or longer from the last radiation treatment. At this stage, if some loss of the transferred tissues results in fat necrosis, removing these firm areas and reshaping the mound (to allow a soft breast reconstruction) allows the patient to more easily perform self-examinations to monitor for cancer recurrence.
If the breast-mound revision is major, nipple reconstruction is delayed another 3-4 months to ensure accurate positioning. Nipple reconstruction can be performed as a local tissue rearrangement or as a graft from the opposite nipple. The anatomy of the patient and the preference of the surgeon dictate the choice.
Stage III - Nipple and areolar tattoo
This final procedure, which is performed in an office setting, adds color to the breast reconstruction. This finishing touch to the reconstruction helps make the reconstructed breast more symmetric with the opposite breast and minimizes the visual effect of other scars that may be present on the breast mound. The tattoo is usually performed 2 months after the nipple reconstruction, because scar tissues are softer at this juncture and can better accept the tattoo pigment.
Consultation is required for the patient to understand the magnitude of the procedure she is about to undergo. Consultation should include discussion of possible complications and unavoidable scars, along with the opportunity to view pictures of an average TRAM flap result. For some women, speaking to a patient who was once in a similar situation is helpful. Answer all questions so that the patient has realistic expectations.
The degree of preparation necessary for such a large procedure is often limited by the need to perform the mastectomy in a timely fashion. Preoperative instructions include the following:
In planning the location of the TRAM flap, remember that it is advantageous to leave the scar as low as possible, similar to the scar left after an abdominoplasty. However, the patient should remember that the location of the fat ultimately dictates the location of the scar. If enough tissue to create a sufficient mound is not present over and immediately adjacent to the muscle, select an alternative technique.
For excellent patient education resources, visit eMedicine's Women's Health Center and Cancer and Tumors Center. Also, see eMedicine's patient education articles Mastectomy, Breast Lumps and Pain, Breast Self-Exam, and Breast Cancer.
The free TRAM flap procedure is performed daily and safely by plastic surgeons experienced with microsurgery. Because of the magnitude of the procedure, complications can occur even in the best hands. Possible complications from a free TRAM flap procedure are listed below. Fortunately, major complications are uncommon.
Hartrampf CR Jr. The transverse abdominal island flap for breast reconstruction. A 7- year experience. Clin Plast Surg. Oct 1988;15(4):703-16. [Medline].
Hudson DA. The surgically delayed unipedicled TRAM flap for breast reconstruction. Ann Plast Surg. Mar 1996;36(3):238-42; discussion 242-5. [Medline].
Lejour M, Dome M. Abdominal wall function after rectus abdominis transfer. Plast Reconstr Surg. Jun 1991;87(6):1054-68. [Medline].
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Nahabedian MY, Momen B, Galdino G, Manson PN. Breast Reconstruction with the free TRAM or DIEP flap: patient selection, choice of flap, and outcome. Plast Reconstr Surg. Aug 2002;110(2):466-75; discussion 476-7. [Medline].
Nahabedian MY, Tsangaris T, Momen B. Breast reconstruction with the DIEP flap or the muscle-sparing (MS-2) free TRAM flap: is there a difference?. Plast Reconstr Surg. Feb 2005;115(2):436-44; discussion 445-6. [Medline].
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Alderman AK, Wilkins EG. Radiation therapy in postmastectomy TRAM reconstruction. Plast Reconstr Surg. Mar 2002;109(3):1199-200. [Medline].
Bostwick J. Microsurgical techniques. In: Plastic and Reconstructive Breast Surgery. 2nd ed. St. Louis: Quality Medical Publishing Inc; 2000:1147-1252.
Chevray PM. Breast reconstruction with superficial inferior epigastric artery flaps: a prospective comparison with TRAM and DIEP flaps. Plast Reconstr Surg. Oct 2004;114(5):1077-83; discussion 1084-5. [Medline].
Grotting JC, Oslin BD. Free TRAM flap breast reconstruction. In: Spear SL. Surgery of the Breast: Principles and Art. Philadelphia, Pa: Lippincott-Raven Publishers; 1998:555-563.
Lindsey JT. Integrating the DIEP and muscle-sparing (MS-2) free TRAM techniques optimizes surgical outcomes: presentation of an algorithm for microsurgical breast reconstruction based on perforator anatomy. Plast Reconstr Surg. Jan 2007;119(1):18-27. [Medline].
Moon HK, Taylor GI. The vascular anatomy of rectus abdominis musculocutaneous flaps based on the deep superior epigastric system. Plast Reconstr Surg. Nov 1988;82(5):815-32. [Medline].
Slavin SA, Goldwyn RM. The midabdominal rectus abdominis myocutaneous flap: review of 236 flaps. Plast Reconstr Surg. Feb 1988;81(2):189-99. [Medline].
Thoma A, Veltri K, Khuthaila D, et al. Comparison of the deep inferior epigastric perforator flap and free transverse rectus abdominis myocutaneous flap in postmastectomy reconstruction: a cost-effectiveness analysis. Plast Reconstr Surg. May 2004;113(6):1650-61. [Medline].
Zenn MR. Control of breast contour by the use of Z-plasty in the irradiated breast reconstruction. Plast Reconstr Surg. Jul 2003;112(1):210-4. [Medline].
breast reconstruction, transverse rectus abdominis myocutaneous flap, TRAM flap, autogenous tissue, free flap, microsurgery, deep inferior epigastric perforator flap, DIEP flap, superficial inferior epigastric perforator flap, SIEP flap, free-tissue transfer, TRAM flap breast reconstruction, mastectomy, chest irradiation, radiation injury, breast mount, belly tissues, breast symmetry, breast revision, nipple reconstruction, nipple tattoo, areolar tattoo
Michael R Zenn, MD, FACS, Associate Professor, Division of Plastic and Reconstructive Surgery, Program Director of Plastic Surgery Residency, Duke University Medical Center
Michael R Zenn, MD, FACS is a member of the following medical societies: Alpha Omega Alpha, American Association of Plastic Surgeons, American College of Surgeons, American Medical Association, American Society for Reconstructive Microsurgery, American Society of Plastic Surgeons, North Carolina Medical Society, Phi Beta Kappa, Plastic Surgery Research Council, Southeastern Society of Plastic and Reconstructive Surgeons, and World Society for Reconstructive Microsurgery
Disclosure: Nothing to disclose.
Pankaj Tiwari, MD, Assistant Professor, Division of Plastic Surgery, Ohio State University
Disclosure: Nothing to disclose.
Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: eMedicine Salary Employment
Saleh M Shenaq, MD, Former Director and Founder, The International Brachial Plexus Institute; Former Chief, Section of Plastic Surgery, Methodist Hospital, Houston
Saleh M Shenaq, MD is a member of the following medical societies: American Academy of Anti-Aging Medicine, American Academy of Pediatrics, American Association for Hand Surgery, American Association for the Advancement of Science, American Association of Plastic Surgeons, American Burn Association, American College of Physician Executives, American College of Surgeons, American Congress of Rehabilitation Medicine, American Medical Association, American Society for Aesthetic Plastic Surgery, American Society for Reconstructive Microsurgery, American Society for Surgery of the Hand, American Society of Gene Therapy, American Society of Law Medicine and Ethics, American Society of Maxillofacial Surgeons, American Society of Plastic Surgeons, American Trauma Society, Association for Academic Surgery, International College of Surgeons, Lipoplasty Society of North America, Plastic Surgery Research Council, Society for Neuroscience, Society of Surgical Oncology, Southern Medical Association, Texas Medical Association, and Texas Society of Plastic Surgeons
Disclosure: Nothing to disclose.
Nicolas (Nick) G Slenkovich, MD, Director, Colorado Plastic Surgery Center
Nicolas (Nick) G Slenkovich, MD is a member of the following medical societies: American Academy of Otolaryngology-Head and Neck Surgery, American College of Surgeons, American Medical Association, American Society of Aesthetic Plastic Surgery, American Society of Plastic Surgeons, and Colorado Medical Society
Disclosure: Nothing to disclose.
Al Aly, MD, FACS, Consulting Surgeon, Iowa City Plastic Surgery
Disclosure: Ethicon Consulting fee Consulting; QMP Royalty Book royalty; Insorb Stapler Consulting fee Consulting; Insorb Stapler Ownership interest None; Medicis Intellectual property rights None
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