eMedicine Specialties > Plastic Surgery > Craniofacial

Craniofacial, Distraction Osteogenesis: Treatment

Author: Pravin K Patel, MD, Associate Professor of Surgery, Division of Plastic Surgery, Northwestern University School of Medicine; Chief of Plastic and Craniofacial Surgery, Shriners Hospitals for Children; Head of Craniofacial Surgery, Children's Memorial Hospital
Coauthor(s): Marco F Ellis, MD, Resident Physician, Department of Plastic and Reconstructive Surgery, Northwestern Memorial Hospital; Linping Zhao, PhD, MSE, Research Specialist and Craniofacial Fellow, Shriners Hospitals for Children, Chicago; Visiting Research Specialist in Biomedical Engineering, Department of Surgery, University of Illinois Medical Center; Adjunct Assistant Professor, Bioengineering Department, University of Illinois at Chicago
Contributor Information and Disclosures

Updated: Jun 30, 2009

Treatment

Surgical Therapy

Regardless of which facial skeletal element is undergoing distraction, the treatment can be divided broadly into the following phases:

  • Presurgical phase
  • Operative phase
  • Lag phase
  • Distraction phase
  • Consolidation phase
  • Retention phase
Presurgical phase

This phase involves radiographic studies to determine the feasibility of placement of the distraction device, whether an internal or external device is more appropriate, and the vector (direction, amplitude) of the distraction. Anticipated trajectory depends directly on the distraction vector, which can be vertical, horizontal, or oblique. Multiplanar devices even allow manipulation of the vector during the distraction phase. When possible, 3-D electronic or manufactured models help to visualize the placement of the device and simulate the distraction process. Involvement of the orthodontist is essential during this phase. Presurgical orthodontic preparation assists the skeletal distraction by providing an occlusal guide.

Presurgical planning to determine the distraction...

Presurgical planning to determine the distraction vector and osteotomies.

Presurgical planning to determine the distraction...

Presurgical planning to determine the distraction vector and osteotomies.


Operative phase

Osteotomies used with distraction are well described with the conventional reconstructive approaches and need only be modified to accommodate the specific device. While the exact details may vary with the procedure, the following are guidelines:

  • Mandibular distraction
    • Adequate mandibular bone stock must be available for the osteotomy and placement of the device.
    • Numerous factors should be considered when deciding between an internal versus external device. External devices allow for more predictable, multidirectional control of the distraction, which cannot be achieved with the currently available internal devices.8 However, external devices require multiple skin incisions that may lead to significant facial scarring. For many children and their families, the application of sequential distraction-vectors with a series of internal devices is preferable to the risk of permanent external scars.
    • The approach, either intraoral or extraoral, depends upon the degree of bony and soft-tissue exposure required for placement of the device and the allowable maxillary-mandibular opening.
    • The placement and direction of the device dictates the distraction vector. The osteotomy line does not necessarily need to be perpendicular to the distraction vector but should be placed to avoid injury to the inferior alveolar nerve and the developing dentition. In addition, avoidance of such injury can be facilitated by an incomplete osteotomy with subsequent separation occurring during the distraction phase.

      Intraoperative photographs of distractor placemen...

      Intraoperative photographs of distractor placement.

      Intraoperative photographs of distractor placemen...

      Intraoperative photographs of distractor placement.

    • Temporarily fixing the distractor into position before making the osteotomy can simplify distractor placement. Positioning the device after the osteotomy can be difficult because of the mobility of the proximal segment.
    • Employ standard principles of a sagittal split osteotomy when lengthening the mandibular body. Preserve the nerve by using a reciprocating saw for the buccal corticotomy and “green-stick” fracturing the lingual cortex with an osteotome. Complete mobilization is not always necessary, since the distraction device completes the osteotomy. Warn the patient and family of the discomfort the patient will feel until the fracture is completed.
    • Prior to closure, test the device and clearly mark for the family the direction (clockwise or counterclockwise) of the driver used to turn the device.
  • Midfacial and frontofacial distraction
    • The use of external devices (head frame and/or helmet) typically requires the presurgical placement of a palatal appliance to guide the horizontal distraction vector.
    • Completely mobilize the midface with conventional approaches and osteotomies.
    • Avoid dental root disruption during the stages of primary or mixed dentition by modifying the typical Le Fort I osteotomy. Place the horizontal cut more cephalad, near the level of the inferior orbital foramen.
    • Midfacial advancements at the Le Fort I level with currently available internal devices are limited because of the difficulty in appropriately orienting the devices in the limited space. The fixation of the device may also injure the developing dentition. External multidirectional devices are preferred as they allow more control over the distraction process.
    • Midfacial advancement at the Le Fort III level9 and frontofacial advancements can be approached with either internal or external devices, depending on the circumstances. Place the internal devices at the level of the body and arch of the zygoma. External devices require a palatal appliance and additional traction wires at the zygoma, nasal root, and supraorbital regions.

Lag phase

Before proceeding with distraction, a period of 5-7 days after the operation must elapse. This latency phase allows for initial osteotomy healing. In patients younger than 4-5 y, the latency period may be significantly shortened or omitted altogether to prevent early consolidation.

Distraction phase

The process of distraction is activated when bone segments are gradually pulled apart using either an internal or external device. Three variables must be set: the rate of distraction, the rhythm or frequency of distraction, and the total time of distraction. The rate of distraction is typically 1.0 mm/d.10 Some advocate up to 2.0 mm/d in younger children to avoid early consolidation and a slower rate of 0.25-0.5 mm/d in older patients. This can be accomplished either once a day or divided throughout the day, determining the rhythm or frequency of distraction. While the distraction rate is 1.0 mm/d, ideally maintain the tissues under constant tension by dividing the total daily rate of distraction into smaller increments throughout the day to favor histogenesis.

The total time of the distraction phase is customized to the severity of the deformity and the patient’s demographics. There can be a discrepancy between the anticipated bone length and the total time of distraction. External devices that use pins to transmit the forces frequently bend, and the distance at the site of the distracting mechanism rarely equals the distance of the gap at the osteotomy sites. In hemifacial microsomia, for example, the position of the menton, distance from the lateral canthus to the commissure, and the mandibular cant should serve as clinical guidelines.

Consolidation phase

Once the desired correction is achieved with the distraction phase, allow mineralization of the immature bone to occur. Lock the distracting appliance into place to maintain stability until the newly formed bone has sufficient strength. The length of this phase varies depending on the circumstances. In general, 6-8 weeks is considered adequate. A guideline used by some centers is 2 days of consolidation to every day of distraction.

Retention phase

Remove the device and maintain stability, typically with the assistance of orthodontic appliances. In children with hemifacial microsomia, this step may require occlusal splints to guide the maxilla into position when the leveling of the mandibular cant creates a posterior open bite. In children with midfacial deformity, retention may require a face mask with elastic traction for a period of time.

Complications

Complications specific to the distraction process include the following:

  • Device mechanism failure
  • Injury to the developing tooth follicles (eg, maxillary and mandibular osteotomies)
  • Injury to various branches of the facial or trigeminal nerves (eg, the inferior alveolar nerve with mandibular distraction)
  • Pin site infection with external devices or semiburied devices
  • Nonunion and premature fusion
  • Complications specific to the osteotomy
  • Psychosocial issues related to the recovery (length of treatment time and patient's physical appearance with distraction device)

More on Craniofacial, Distraction Osteogenesis

Overview: Craniofacial, Distraction Osteogenesis
Workup: Craniofacial, Distraction Osteogenesis
Treatment: Craniofacial, Distraction Osteogenesis
Follow-up: Craniofacial, Distraction Osteogenesis
Multimedia: Craniofacial, Distraction Osteogenesis
References

References

  1. Ilizarov GA. The Transosseous Osteosynthesis: Theoretical and Clinical Aspects of the Regeneration and Growth of Tissue. New York: Springer-Verlag;1992.

  2. McCarthy JG, Schreiber J, Karp N. Lengthening the human mandible by gradual distraction. Plast Reconstr Surg. Jan 1992;89(1):1-8; discussion 9-10. [Medline].

  3. Steinberg B, Fattahi T. Distraction osteogenesis in management of pediatric airway: evidence to support its use. J Oral Maxillofac Surg. Aug 2005;63(8):1206-8. [Medline].

  4. Denny AD. Distraction osteogenesis in Pierre Robin neonates with airway obstruction. Clin Plast Surg. Apr 2004;31(2):221-9. [Medline].

  5. Fritz MA, Sidman JD. Distraction osteogenesis of the mandible. Curr Opin Otolaryngol Head Neck Surg. Dec 2004;12(6):513-8. [Medline].

  6. Li HY, Lee LA. Sleep-disordered Breathing in Children. Chang Gung Med J. May-Jun 2009;32(3):247-57. [Medline].

  7. Kaban LB, Seldin EB, Kikinis R, Yeshwant K, Padwa BL, Troulis MJ. Clinical application of curvilinear distraction osteogenesis for correction of mandibular deformities. J Oral Maxillofac Surg. May 2009;67(5):996-1008. [Medline].

  8. Polley JW, Figueroa AA. Management of severe maxillary deficiency in childhood and adolescence through distraction osteogenesis with an external, adjustable, rigid distraction device. J Craniofac Surg. May 1997;8(3):181-5; discussion 186. [Medline].

  9. Chin M, Toth BA. Le Fort III advancement with gradual distraction using internal devices. Plast Reconstr Surg. Sep 1997;100(4):819-30; discussion 831-2. [Medline].

  10. Nada RM, Sugar AW, Wijdeveld MG, et al. Current practice of distraction osteogenesis for craniofacial anomalies in Europe: A web based survey. J Craniomaxillofac Surg. May 15 2009;[Medline].

  11. Cohen SR, Boydston W, Burstein FD. Monobloc distraction osteogenesis during infancy: report of a case and presentation of a new device. Plast Reconstr Surg. Jun 1998;101(7):1919-24. [Medline].

  12. Figueroa AA, Polley JW, Friede H, Ko EW. Long-term skeletal stability after maxillary advancement with distraction osteogenesis using a rigid external distraction device in cleft maxillary deformities. Plast Reconstr Surg. Nov 2004;114(6):1382-92; discussion 1393-4. [Medline].

  13. Grubb J, Smith T. Practical applications of distraction osteogenesis. Am J Orthod Dentofacial Orthop. Sep 2004;126(3):271-2. [Medline].

  14. McCarthy JG. Distraction of the Craniofacial Skeleton. New York: Springer-Verlag; 1999.

  15. Menezes RD, Zhao L, Patel PK, Modi V. Volumetric changes in the oropharyngeal airway following bilateral mandibular distraction osteogenesis in Pierre Robin Sequence. J Craniofac Surg. Article submitted July 2008.

  16. Mikhail L, Samchukov JB, Cope A. Craniofacial Distraction Osteogenesis. CV Mosby; 2001.

  17. Molina F, Ortiz Monasterio F. Mandibular elongation and remodeling by distraction: a farewell to major osteotomies. Plast Reconstr Surg. Sep 1995;96(4):825-40; discussion 841-2. [Medline].

  18. Wan DC, Nacamuli RP, Longaker MT. Craniofacial bone tissue engineering. Dent Clin North Am. Apr 2006;50(2):175-90, vii. [Medline].

Further Reading

Keywords

distraction osteogenesis, bone lengthening, de novo bone formation, osteotomized bone segments, maxillary deformity, osteogenesis, mandible distraction, craniofacial deformity, hemifacial microsomia, mandibular hypoplasia, tracheostomy, neonatal distraction, pierre robin, Pierre Robin, hypoplastic mandible, mandible surgery, facial surgery, pediatric facial surgery, midfacial deformity, dentofacial deformity, deficient alveolar ridge, orbitofrontal advancement

Contributor Information and Disclosures

Author

Pravin K Patel, MD, Associate Professor of Surgery, Division of Plastic Surgery, Northwestern University School of Medicine; Chief of Plastic and Craniofacial Surgery, Shriners Hospitals for Children; Head of Craniofacial Surgery, Children's Memorial Hospital
Disclosure: Nothing to disclose.

Coauthor(s)

Marco F Ellis, MD, Resident Physician, Department of Plastic and Reconstructive Surgery, Northwestern Memorial Hospital
Marco F Ellis, MD is a member of the following medical societies: American College of Surgeons and American Society of Plastic Surgeons
Disclosure: Nothing to disclose.

Linping Zhao, PhD, MSE, Research Specialist and Craniofacial Fellow, Shriners Hospitals for Children, Chicago; Visiting Research Specialist in Biomedical Engineering, Department of Surgery, University of Illinois Medical Center; Adjunct Assistant Professor, Bioengineering Department, University of Illinois at Chicago
Linping Zhao, PhD, MSE is a member of the following medical societies: American Cleft Palate/Craniofacial Association and American Society of Mechanical Engineers
Disclosure: Nothing to disclose.

Medical Editor

John Persing, MD, Chief, Professor, Department of Surgery, Sections of Plastic Surgery and Neurosurgery, Yale University School of Medicine
John Persing, MD is a member of the following medical societies: American Academy of Pediatrics, American Association of Neurological Surgeons, American Association of Plastic Surgeons, American Cleft Palate/Craniofacial Association, American College of Surgeons, American Medical Association, American Society of Maxillofacial Surgeons, New York Academy of Sciences, and Society for Neuroscience
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: eMedicine Salary Employment

Managing Editor

R Edward Newsome, MD, Program Director and Chief of Plastic Surgery, Henderson Chair in Surgery, Assistant Dean for Graduate Medical Education, Tulane University School of Medicine
R Edward Newsome, MD is a member of the following medical societies: American College of Surgeons, American Medical Association, American Society of Plastic and Reconstructive Surgery, American Society of Plastic Surgeons, and Louisiana State Medical Society
Disclosure: Nothing to disclose.

CME Editor

Nicolas (Nick) G Slenkovich, MD, Director, Colorado Plastic Surgery Center
Nicolas (Nick) G Slenkovich, MD is a member of the following medical societies: American Academy of Otolaryngology-Head and Neck Surgery, American College of Surgeons, American Medical Association, American Society of Aesthetic Plastic Surgery, American Society of Plastic Surgeons, and Colorado Medical Society
Disclosure: Nothing to disclose.

Chief Editor

Jorge I de la Torre, MD, FACS, Professor of Surgery and Physical Medicine and Rehabilitation, Residency Program Director, Division of Plastic Surgery, University of Alabama at Birmingham; Director, Center for Advanced Surgical Aesthetics
Jorge I de la Torre, MD, FACS is a member of the following medical societies: American Association of Plastic Surgeons, American Burn Association, American College of Surgeons, American Medical Association, American Society for Laser Medicine and Surgery, American Society for Reconstructive Microsurgery, American Society of Maxillofacial Surgeons, American Society of Plastic Surgeons, Association for Academic Surgery, and Medical Association of the State of Alabama
Disclosure: Nothing to disclose.

 
 
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