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Thyroid Dysfunction Induced by Amiodarone Therapy Differential Diagnoses

  • Author: Mini Gopalan, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
 
Updated: Jul 12, 2016
 
 
 
Contributor Information and Disclosures
Author

Mini Gopalan, MD Clinical Assistant Professor, Department of Medicine, Texas Tech University; Consulting Physician, Department of Internal Medicine, Midland Community Healthcare Services

Mini Gopalan, MD is a member of the following medical societies: American College of Physicians, American Medical Association, Endocrine Society, Texas Medical Association

Disclosure: Nothing to disclose.

Coauthor(s)

James Burks, MD, FACP, FACE Professor of Medicine, Program Director, Department of Medicine, Texas Tech University Health Sciences Center

James Burks, MD, FACP, FACE is a member of the following medical societies: American Association of Clinical Endocrinologists, American Diabetes Association, Endocrine Society

Disclosure: Nothing to disclose.

Specialty Editor Board

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Arthur B Chausmer, MD, PhD, FACP, FACE, FACN, CNS Professor of Medicine (Endocrinology, Adj), Johns Hopkins School of Medicine; Affiliate Research Professor, Bioinformatics and Computational Biology Program, School of Computational Sciences, George Mason University; Principal, C/A Informatics, LLC

Arthur B Chausmer, MD, PhD, FACP, FACE, FACN, CNS is a member of the following medical societies: American Association of Clinical Endocrinologists, American College of Nutrition, American Society for Bone and Mineral Research, International Society for Clinical Densitometry, American College of Endocrinology, American College of Physicians, American College of Physicians-American Society of Internal Medicine, American Medical Informatics Association, Endocrine Society

Disclosure: Nothing to disclose.

Chief Editor

Romesh Khardori, MD, PhD, FACP Professor of Endocrinology, Director of Training Program, Division of Endocrinology, Diabetes and Metabolism, Strelitz Diabetes and Endocrine Disorders Institute, Department of Internal Medicine, Eastern Virginia Medical School

Romesh Khardori, MD, PhD, FACP is a member of the following medical societies: American Association of Clinical Endocrinologists, American College of Physicians, American Diabetes Association, Endocrine Society

Disclosure: Nothing to disclose.

Acknowledgements

Robert A Gabbay, MD, PhD Associate Professor of Medicine, Division of Endocrinology, Diabetes and Metabolism, Laurence M Demers Career Development Professor, Penn State College of Medicine; Director, Diabetes Program, Penn State Milton S Hershey Medical Center; Executive Director, Penn State Institute for Diabetes and Obesity

Robert A Gabbay, MD, PhD is a member of the following medical societies: American Association of Clinical Endocrinologists, American Diabetes Association, and Endocrine Society

Disclosure: Novo Nordisk Honoraria Speaking and teaching; Merck Honoraria Speaking and teaching

References
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  2. Ahmed S, Van Gelder IC, Wiesfeld AC, Van Veldhuisen DJ, Links TP. Determinants and outcome of amiodarone-associated thyroid dysfunction. Clin Endocrinol (Oxf). 2011 Sep. 75(3):388-94. [Medline].

  3. Mosher MC. Amiodarone-induced hypothyroidism and other adverse effects. Dimens Crit Care Nurs. 2011 Mar-Apr. 30(2):87-93. [Medline].

  4. Hofmann A, Nawara C, Ofluoglu S, et al. Incidence and predictability of amiodarone-induced thyrotoxicosis and hypothyroidism. Wien Klin Wochenschr. 2008. 120(15-16):493-8. [Medline].

  5. Diederichsen SZ, Darkner S, Chen X, et al. Short-term amiodarone treatment for atrial fibrillation after catheter ablation induces a transient thyroid dysfunction: results from the placebo-controlled, randomized AMIO-CAT trial. Eur J Intern Med. 2016 Apr 26. [Medline].

  6. Zhong B, Wang Y, Zhang G, Wang Z. Environmental Iodine Content, Female Sex and Age Are Associated with New-Onset Amiodarone-Induced Hypothyroidism: A Systematic Review and Meta-Analysis of Adverse Reactions of Amiodarone on the Thyroid. Cardiology. 2016. 134(3):366-71. [Medline].

  7. Piga M, Serra A, Boi F, et al. Amiodarone-induced thyrotoxicosis. A review. Minerva Endocrinol. 2008 Sep. 33(3):213-28. [Medline].

  8. Piga M, Cocco MC, Serra A, et al. The usefulness of 99mTc-sestaMIBI thyroid scan in the differential diagnosis and management of amiodarone-induced thyrotoxicosis. Eur J Endocrinol. 2008 Oct. 159(4):423-9. [Medline].

  9. Bogazzi F, Bartalena L, Tomisti L, et al. Potassium perchlorate only temporarily restores euthyroidism in patients with amiodarone-induced hypothyroidism who continue amiodarone therapy. J Endocrinol Invest. 2008 Jun. 31(6):515-9. [Medline].

  10. Han TS, Williams GR, Vanderpump MP. Benzofuran derivatives and the thyroid. Clin Endocrinol (Oxf). 2009 Jan. 70(1):2-13. [Medline].

  11. Eaton SE, Euinton HA, Newman CM, et al. Clinical experience of amiodarone-induced thyrotoxicosis over a 3-year period: role of colour-flow Doppler sonography. Clin Endocrinol (Oxf). 2002 Jan. 56(1):33-8. [Medline].

  12. Hermida JS, Jarry G, Tcheng E, Moullart V, Arlot S, Rey JL. Radioiodine ablation of the thyroid to allow the reintroduction of amiodarone treatment in patients with a prior history of amiodarone-induced thyrotoxicosis. Am J Med. 2004 Mar 1. 116(5):345-8. [Medline].

  13. Jabrocka-Hybel A, Bednarczuk T, Bartalena L, Pach D, Ruchała M, et al. Amiodarone and the thyroid. Endokrynol Pol. 2015. 66 (2):176-86. [Medline].

  14. Costache L, Mogos V, Preda C, Vulpoi C, Ungureanu MC. Therapeutic particularities in amiodarone induced thyroid disorder in patients with underlying cardiac condition. Rev Med Chir Soc Med Nat Iasi. 2014 Oct-Dec. 118 (4):959-64. [Medline].

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