Surgical Treatment of Pressure Ulcers Workup
- Author: Bradon J Wilhelmi, MD; Chief Editor: Lars M Vistnes, MD, FRCSC, FACS more...
Laboratory Studies
- Osteomyelitis is suggested by an erythrocyte sedimentation rate (ESR) greater than 120 mm/h and a WBC count greater than 15,000/µL.
- Preoperative nutritional status can be determined by obtaining the patient's albumin level, which should be optimized to at least 3.5 g/mL prior to flap reconstruction. These patients often have anemia of chronic disease, suggested by a low mean corpuscular volume, and can be considered for a transfusion in order to achieve a preoperative hemoglobin level greater than 12 g.
Imaging Studies
- Diagnosis of underlying osteomyelitis can be evaluated first with plain films. Osteomyelitis can also suggested by positive bone scan findings. A negative bone scan finding generally excludes osteomyelitis. However, patients with an open wound such as a pressure sore can often have a falsely positive bone scan. A positive bone scan finding can be evaluated further with an MRI or bone biopsy.
Diagnostic Procedures
- Bone biopsy is the criterion standard for the diagnosis of osteomyelitis within a pressure sore.[14] Bone biopsy should be considered in patients with elevated ESR, elevated WBC, and or abnormal pelvic films suggestive of osteomyelitis.
Davis JS. Operative treatment of scars following bed sores. Surgery. 1938;3:1.
Kostrubala JG, Greeley PW. The problem of decubitus ulcers in paraplegics. Plast Reconstr Surg. 1947;2:403.
Manley MT. Incidence, contributory factors and costs of pressure sores. S Afr Med J. Feb 11 1978;53(6):217-22. [Medline].
Barbenel JC, Jordan MM, Nicol SM, et al. Incidence of pressure-sores in the Greater Glasgow Health Board area. Lancet. Sep 10 1977;2(8037):548-50. [Medline].
Paletta C, Bartell T, Shehadi S. Applications of the posterior thigh flap. Ann Plast Surg. Jan 1993;30(1):41-7. [Medline].
Charcot JM. Lectures on the Diseases of the Nervous System. 2nd ed. Sigerson G, trans. Delivered at La Saltpetriere. Philadelphia: Henry C Lea; 1879.
Brown Sequard E. Experimental research applied to physiology and pathology. Med Exam Rec Med Sci. 1852;16:481.
Lindan O, Greenway RM, Piazza JM. Pressure distribution on the surface of the human body. Evaluation in lying and sitting positions using a bed of springs and nails. Arch Phys Med Rehabil. May 1965;46:378-85. [Medline].
Le KM, Madsen BL, Barth PW, et al. An in-depth look at pressure sores using monolithic silicon pressure sensors. Plast Reconstr Surg. Dec 1984;74(6):745-56. [Medline].
Witkowski JA, Parish LC. Histopathology of the decubitus ulcer. J Am Acad Dermatol. Jun 1982;6(6):1014-21. [Medline].
El-Toraei I, Chung B. The management of pressure sores. J Dermatol Surg Oncol. Sep-Oct 1977;3(5):507-11. [Medline].
Barczak CA, Barnett RI, Childs EJ, et al. Fourth national pressure ulcer prevalence survey. Adv Wound Care. Jul-Aug 1997;10(4):18-26. [Medline].
Daniel RK, Faibisoff B. Muscle coverage of pressure points--the role of myocutaneous flaps. Ann Plast Surg. Jun 1982;8(6):446-52. [Medline].
Lewis VL Jr, Bailey MH, Pulawski G, et al. The diagnosis of osteomyelitis in patients with pressure sores. Plast Reconstr Surg. Feb 1988;81(2):229-32. [Medline].
Ferrell BA, Osterweil D, Christenson P. A randomized trial of low-air-loss beds for treatment of pressure ulcers. JAMA. Jan 27 1993;269(4):494-7. [Medline].
Bennett RG, Bellantoni MF, Ouslander JG. Air-fluidized bed treatment of nursing home patients with pressure sores. J Am Geriatr Soc. Mar 1989;37(3):235-42. [Medline].
Lin H, Hou C, Chen A, Xu Z. Treatment of Ischial Pressure Sores Using a Modified Gracilis Myofasciocutaneous Flap. J Reconstr Microsurg. Nov 9 2009;[Medline].
Gould WL, Montero N, Cukic J, et al. The "split" gluteus maximus musculocutaneous flap. Plast Reconstr Surg. Feb 1994;93(2):330-6. [Medline].
Koshima I, Moriguchi T, Soeda S, et al. The gluteal perforator-based flap for repair of sacral pressure sores. Plast Reconstr Surg. Apr 1993;91(4):678-83. [Medline].
Hill HL, Brown RG, Jurkiewicz MJ. The transverse lumbosacral back flap. Plast Reconstr Surg. Aug 1978;62(2):177-84. [Medline].
Nahai F, Silverton JS, Hill HL, et al. The tensor fascia lata musculocutaneous flap. Ann Plast Surg. Jul 1978;1(4):372-9. [Medline].
Anthony JP, Mathes SJ, Alpert BS. The muscle flap in the treatment of chronic lower extremity osteomyelitis: results in patients over 5 years after treatment. Plast Reconstr Surg. Aug 1991;88(2):311-8. [Medline].
Evans GR, Lewis VL Jr, Manson PN, et al. Hip joint communication with pressure sore: the refractory wound and the role of Girdlestone arthroplasty. Plast Reconstr Surg. Feb 1993;91(2):288-94. [Medline].
Evans GR, Dufresne CR, Manson PN. Surgical correction of pressure ulcers in an urban center: is it efficacious?. Adv Wound Care. Jan 1994;7(1):40-6. [Medline].
Copcu E. Marjolin's ulcer: a preventable complication of burns?. Plast Reconstr Surg. Jul 2009;124(1):156e-64e. [Medline].
Berkwits L, Yarkony GM, Lewis V. Marjolin's ulcer complicating a pressure ulcer: case report and literature review. Arch Phys Med Rehabil. Nov 1986;67(11):831-3. [Medline].
Mustoe T, Upton J, Marcellino V, et al. Carcinoma in chronic pressure sores: a fulminant disease process. Plast Reconstr Surg. Jan 1986;77(1):116-21. [Medline].
Atri SC, Misra J, Bisht D, et al. Use of homologous platelet factors in achieving total healing of recalcitrant skin ulcers. Surgery. Sep 1990;108(3):508-12. [Medline].
Robson MC, Phillips LG, Thomason A, et al. Platelet-derived growth factor BB for the treatment of chronic pressure ulcers. Lancet. Jan 4 1992;339(8784):23-5. [Medline].
Robson MC, Phillips LG, Thomason A, et al. Recombinant human platelet-derived growth factor-BB for the treatment of chronic pressure ulcers. Ann Plast Surg. Sep 1992;29(3):193-201. [Medline].
Mustoe TA, Cutler NR, Allman RM, et al. A phase II study to evaluate recombinant platelet-derived growth factor- BB in the treatment of stage 3 and 4 pressure ulcers. Arch Surg. Feb 1994;129(2):213-9. [Medline].
Anthony JP, Mathes SJ. Update on chronic osteomyelitis. Clin Plast Surg. Jul 1991;18(3):515-23. [Medline].
Aoi N, Yoshimura K, Kadono T, Nakagami G, Iizuka S, Higashino T, et al. Ultrasound assessment of deep tissue injury in pressure ulcers: possible prediction of pressure ulcer progression. Plast Reconstr Surg. Aug 2009;124(2):540-50. [Medline].
Berlowitz DR, Wilking SV. Risk factors for pressure sores. A comparison of cross-sectional and cohort-derived data. J Am Geriatr Soc. Nov 1989;37(11):1043-50. [Medline].
Bruck JC, Büttemeyer R, Grabosch A, et al. More arguments in favor of myocutaneous flaps for the treatment of pelvic pressure sores. Ann Plast Surg. Jan 1991;26(1):85-8. [Medline].
Calderon WL, Llanos S, Leniz P, Danilla S, Vielma R, Calderon D. Double negative pressure for seroma treatment in trocanteric area. Ann Plast Surg. Dec 2009;63(6):659-60. [Medline].
Capen DA. Staged total thigh rotation flap for coverage of chronic recurrent pressure sores. Contemp Orthop. 1988;16:23.
Colen SR. Pressure sore. In: McCarthy Plastic Surgery. Philadelphia, Pa: WB Saunders Co; 1990:3797-838.
Crenshaw RP, Vistnes LM. A decade of pressure sore research: 1977-1987. J Rehabil Res Dev. Winter 1989;26(1):63-74. [Medline].
Dansereau JG, Conway H. Closure of decubiti in paraplegics. Report of 2000 cases. Plast Reconstr Surg. May 1964;33:474-80. [Medline].
Dinsdale SM. Decubitus ulcers: role of pressure and friction in causation. Arch Phys Med Rehabil. Apr 1974;55(4):147-52. [Medline].
Esposito G, Di Caprio G, Ziccardi P, et al. Tissue expansion in the treatment of pressure ulcers. Plast Reconstr Surg. Mar 1991;87(3):501-8. [Medline].
Georgiade N, Pickrell K, Maguire C. Total thigh flaps for extensive decubitus ulcers. Plast reconstr surg (1946). Mar 1956;17(3):220-5. [Medline].
Ger R, Levine SA. The management of decubitus ulcers by muscle transposition. An 8-year review. Plast Reconstr Surg. Oct 1976;58(4):419-28. [Medline].
Hurwitz DJ. The gluteus maximus muscle musculocutaneous flap. In: Serafin D, ed. Atlas of Microsurgical Composite Tissue Transplantation. Philadelphia, Pa: WB Saunders Co; 1996:259-70.
Hurwitz DJ, Swartz WM, Mathes SJ. The gluteal thigh flap: a reliable, sensate flap for the closure of buttock and perineal wounds. Plast Reconstr Surg. Oct 1981;68(4):521-32. [Medline].
Hurwitz DJ, Walton RL. Closure of chronic wounds of the perineal and sacral regions using the gluteal thigh flap. Ann Plast Surg. May 1982;8(5):375-86. [Medline].
Husain T. An experimental study of some pressure effects on tissues, with reference to the bed-sore problem. J Pathol Bacteriol. Oct 1953;66(2):347-58. [Medline].
Jakubietz RG, Jakubietz MG, Jakubietz DF, Koehler G, Zeplin PH, Meffert RH, et al. Ischial pressure sores: reconstruction using the perforator-based reverse flow musculocutaneous 180 degrees propeller flap. Microsurgery. 2009;29(8):672-5. [Medline].
Keane FX. The function of the rump in relation to sitting and the Keane Reciprocating Wheelchair Seat. Paraplegia. Feb 1979;16(4):390-402. [Medline].
Landis DM. Studies of capillary blood pressure in human skin. Heart. 1930;15:209.
Lee HB, Kim SW, Lew DH, et al. Unilateral multilayered musculocutaneous V-Y advancement flap for the treatment of pressure sore. Plast Reconstr Surg. Aug 1997;100(2):340-5; discussion 346-9. [Medline].
Lindan O. Etiology of decubitus ulcers: an experimental study. Arch Phys Med Rehabil. Nov 1961;42:774-83. [Medline].
Mancoll JS, Phillips LG. Pressure sores. In: Archaeur BM, Eriksson E, Guyuron B et al, eds. Plastic Surgery, Indication Operations and Outcomes. St. Louis: Mosby; 2000:447-62.
Mandrekas AD, Mastorakos DP. The management of decubitus ulcers by musculocutaneous flaps: a five-year experience. Ann Plast Surg. Feb 1992;28(2):167-74. [Medline].
Mathes SJ, Nahai F. Gluteus maximus gluteal thigh flap chapter. In: Reconstructive Surgery, Principles, Anatomy, and Technique. New York: Churchill Livingston; 1997:501-35.
Minami RT, Mills R, Pardoe R. Gluteus maximus myocutaneous flaps for repair of pressure sores. Plast Reconstr Surg. Aug 1977;60(2):242-9. [Medline].
Moss RJ, La Puma J. The ethics of pressure sore prevention and treatment in the elderly: a practical approach. J Am Geriatr Soc. Sep 1991;39(9):905-8. [Medline].
Munro D. Care of back following spinal cord injuries. N Engl J Med. 1940;223:391.
Nahai F. The tensor fascia lata flap. In: Serafin D, ed. Atlas of Microsurgical Composite Tissue Transplantation. Philadelphia, Pa: WB Saunders Co; 1996:271-81.
Nola GT, Vistnes LM. Differential response of skin and muscle in the experimental production of pressure sores. Plast Reconstr Surg. Nov 1980;66(5):728-33. [Medline].
Pena MM, Drew GS, Smith SJ, et al. The inferiorly based rectus abdominis myocutaneous flap for reconstruction of recurrent pressure sores. Plast Reconstr Surg. Jan 1992;89(1):90-5. [Medline].
Petersen NC, Bittmann S. The epidemiology of pressure sores. Scand J Plast Reconstr Surg. 1971;5(1):62-6. [Medline].
Pownell PH. Pressure sores. Selected Readings in Plastic Surgery. Plast Surg. 1995;7(39):1-27.
Ramirez OM, Hurwitz DJ, Futrell JW. The expansive gluteus maximus flap. Plast Reconstr Surg. Dec 1984;74(6):757-70. [Medline].
Royer J, Pickrell K, Georgiade N, et al. Total thigh flaps for extensive decubitus ulcers. A 16 year review of 41 total thigh flaps. Plast Reconstr Surg. Aug 1969;44(2):109-18. [Medline].
Sekiguchi J, Kobayashi S, Ohmori K. Free sensory and nonsensory plantar flap transfers in the treatment of ischial decubitus ulcers. Plast Reconstr Surg. Jan 1995;95(1):156-65. [Medline].
Siegler EL, Lavizzo-Mourey R. Management of stage III pressure ulcers in moderately demented nursing home residents. J Gen Intern Med. Nov-Dec 1991;6(6):507-13. [Medline].
Stal S, Serure A, Donovan W, et al. The perioperative management of the patient with pressure sores. Ann Plast Surg. Oct 1983;11(4):347-56. [Medline].
Stallings JO, Delgado JP, Converse JM. Turnover island flap of gluteus maximus muscle for the repair of sacral decubitus ulcer. Plast Reconstr Surg. Jul 1974;54(1):52-4. [Medline].
Stevenson TR, Pollock RA, Rohrich RJ, et al. The gluteus maximus musculocutaneous island flap: refinements in design and application. Plast Reconstr Surg. May 1987;79(5):761-8. [Medline].
Thompson RJ. Pathological changes in mummies. Proc R Soc Med. 1961;54:409.
Tobin GR, Brown GL, Derr JW, et al. V-Y advancement flaps. Reusable flaps for pressure ulcer repair. Clin Plast Surg. Oct 1990;17(4):727-32. [Medline].
Yamamoto Y, Ohura T, Shintomi Y, et al. Superiority of the fasciocutaneous flap in reconstruction of sacral pressure sores. Ann Plast Surg. Feb 1993;30(2):116-21. [Medline].

