Venous Malformations Workup

  • Author: Silvio Podda, MD; Chief Editor: Gregory Caputy, MD, PhD, FICS   more...
 
Updated: Nov 21, 2011
 

Laboratory Studies

  • Typically, no laboratory tests are indicated for cutaneous venous malformations. Clotting studies and CBC may be indicated in an occasional visceral lesion that is bleeding. If a particular anomaly is a diagnostic dilemma, urinary bFGF rarely may be indicated as part of the workup.
  • A 2005 study was able to differentiate between proliferating hemangiomas and vascular malformations based on serum vascular endothelial growth factor (VEGF) levels.[1]
  • Perform a coagulation profile on children with extensive disease, as there is a risk for low-grade, localized intravascular coagulopathy (LIC). Disseminated intravascular coagulopathy (DIC) is rare.
Next

Imaging Studies

  • Plain radiographs - Phleboliths pathognomonic
  • MRI
    • Most informative modality
    • Hyperintense on T2-weighted images
    • No flow voids
    • Inhomogeneous contrast enhancement (like CT)
  • CT scan
    • Inhomogeneous contrast enhancement (like MRI)
    • Phleboliths easily seen
  • Ultrasound - Hypoechogenic, septated mass
Previous
Next

Diagnostic Procedures

  • Arteriography has little or no role in venous malformation unless the diagnosis is unclear.
Previous
Next

Histologic Findings

  • If the diagnosis is in doubt, biopsy the lesion!
  • Most venous malformations are diagnosed based on a good history and physical examination; all of the above studies are ancillary.
Previous
 
 
Contributor Information and Disclosures
Author

Silvio Podda, MD  Craniofacial and Plastic Surgeon, Department of Plastic and Reconstructive Surgery, St Joseph's Regional Medical Center and Children's Hospital

Silvio Podda, MD is a member of the following medical societies: American Medical Association, American Society of Maxillofacial Surgeons, American Society of Plastic Surgeons, and Northeastern Society of Plastic Surgeons

Disclosure: Nothing to disclose.

Coauthor(s)

Frederick J Duffy, Jr, MD, FACS  Clinical Assistant Professor, Department of Plastic Surgery, University of Texas Southwestern Medical School

Frederick J Duffy, Jr, MD, FACS is a member of the following medical societies: American College of Surgeons, American Society for Reconstructive Microsurgery, American Society of Plastic Surgeons, Plastic Surgery Research Council, and Texas Medical Association

Disclosure: Nothing to disclose.

Specialty Editor Board

Shahin Javaheri, MD  Chief, Department of Plastic Surgery, Martinez Veterans Affairs Outpatient Clinic; Consulting Staff, Advanced Aesthetic Plastic & Reconstructive Surgery

Shahin Javaheri, MD is a member of the following medical societies: American Academy of Otolaryngology-Head and Neck Surgery and American Society of Plastic Surgeons

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD  Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Salary Employment

Jorge I de la Torre, MD, FACS  Professor of Surgery and Physical Medicine and Rehabilitation, Chief, Division of Plastic Surgery, Residency Program Director, University of Alabama at Birmingham School of Medicine; Director, Center for Advanced Surgical Aesthetics

Jorge I de la Torre, MD, FACS is a member of the following medical societies: American Association of Plastic Surgeons, American Burn Association, American College of Surgeons, American Medical Association, American Society for Laser Medicine and Surgery, American Society for Reconstructive Microsurgery, American Society of Maxillofacial Surgeons, American Society of Plastic Surgeons, Association for Academic Surgery, and Medical Association of the State of Alabama

Disclosure: Nothing to disclose.

Nicolas (Nick) G Slenkovich, MD  Director, Colorado Plastic Surgery Center

Nicolas (Nick) G Slenkovich, MD is a member of the following medical societies: American Academy of Otolaryngology-Head and Neck Surgery, American College of Surgeons, American Medical Association, American Society of Aesthetic Plastic Surgery, American Society of Plastic Surgeons, and Colorado Medical Society

Disclosure: Nothing to disclose.

Chief Editor

Gregory Caputy, MD, PhD, FICS  Chief Surgeon, Aesthetica Plastic and Laser Surgery Center, Inc

Gregory Caputy, MD, PhD, FICS is a member of the following medical societies: American Society for Laser Medicine and Surgery, Canadian Medical Association, International College of Surgeons, International College of Surgeons US Section, Pan-Pacific Surgical Association, and Wound Healing Society

Disclosure: Syneron Corporation Salary Speaking and teaching

References
  1. Shaw WC. Folklore surrounding facial deformity and the origins of facial prejudice. Br J Plast Surg. Jul 1981;34(3):237-46. [Medline].

  2. Breugem CC, van Der Horst CM, Hennekam RC. Progress toward understanding vascular malformations. Plast Reconstr Surg. May 2001;107(6):1509-23. [Medline].

  3. Mulliken JB, Glowacki J. Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg. Mar 1982;69(3):412-22. [Medline].

  4. Dubois J, Garel L. Imaging and therapeutic approach of hemangiomas and vascular malformations in the pediatric age group. Pediatr Radiol. Dec 1999;29(12):879-93. [Medline].

  5. Boon LM, Mulliken JB, Vikkula M, et al. Assignment of a locus for dominantly inherited venous malformations to chromosome 9p. Hum Mol Genet. Sep 1994;3(9):1583-7. [Medline].

  6. Vikkula M, Boon LM, Carraway KL, et al. Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2. Cell. Dec 27 1996;87(7):1181-90. [Medline].

  7. Hassanein AH, Mulliken JB, Fishman SJ, Alomari AI, Zurakowski D, Greene AK. Venous Malformation: Risk of Progression During Childhood and Adolescence. Ann Plast Surg. May 27 2011;[Medline].

  8. Greene AK, Liu AS, Mulliken JB, Chalache K, Fishman SJ. Vascular anomalies in 5,621 patients: guidelines for referral. J Pediatr Surg. Sep 2011;46(9):1784-9. [Medline].

  9. Hill RA, Pho RW, Kumar VP. Resection of vascular malformations. J Hand Surg [Br]. Feb 1993;18(1):17-21. [Medline].

  10. Hein KD, Mulliken JB, Kozakewich HP, et al. Venous malformations of skeletal muscle. Plast Reconstr Surg. Dec 2002;110(7):1625-35. [Medline].

  11. Pappas DC Jr, Persky MS, Berenstein A. Evaluation and treatment of head and neck venous vascular malformations. Ear Nose Throat J. Nov 1998;77(11):914-6, 918-22. [Medline].

  12. Pascarella L, Bergan JJ, Yamada C, Mekenas L. Venous angiomata: treatment with sclerosant foam. Ann Vasc Surg. Jul 2005;19(4):457-64. [Medline].

  13. Hu X, Chen D, Jiang C, Jin Y, Chen H, Ma G, et al. Retrospective analysis of facial paralysis caused by ethanol sclerotherapy for facial venous malformation. Head Neck. Nov 2011;33(11):1616-21. [Medline].

  14. Rebeiz E, April MM, Bohigian RK, Shapshay SM. Nd-YAG laser treatment of venous malformations of the head and neck: an update. Otolaryngol Head Neck Surg. Nov 1991;105(5):655-61. [Medline].

  15. Fishman SJ, Mulliken JB. Vascular anomalies. A primer for pediatricians. Pediatr Clin North Am. Dec 1998;45(6):1455-77. [Medline].

  16. Berenguer B, Burrows PE, Zurakowski D, Mulliken JB. Sclerotherapy of craniofacial venous malformations: complications and results. Plast Reconstr Surg. Jul 1999;104(1):1-11; discussion 12-5. [Medline].

  17. Enjolras O, Mulliken JB. Vascular tumors and vascular malformations (new issues). Adv Dermatol. 1997;13:375-423. [Medline].

  18. Fishman SJ, Burrows PE, Leichtner AM, Mulliken JB. Gastrointestinal manifestations of vascular anomalies in childhood: varied etiologies require multiple therapeutic modalities. J Pediatr Surg. Jul 1998;33(7):1163-7. [Medline].

  19. Morgan RF, Horowitz JH, Wanebo HJ, Edgerton MT. Surgical management of vascular malformations of the head and neck. Am J Surg. Oct 1986;152(4):424-9. [Medline].

  20. Pryor J, Setton A, Berenstein A. Venous anomalies and associated lesions. Neurosurg Clin N Am. Jul 1999;10(3):519-25. [Medline].

  21. Upton J, Coombs CJ, Mulliken JB, et al. Vascular malformations of the upper limb: a review of 270 patients. J Hand Surg [Am]. Sep 1999;24(5):1019-35. [Medline].

  22. Zhang L, Lin X, Wang W, et al. Circulating level of vascular endothelial growth factor in differentiating hemangioma from vascular malformation patients. Plast Reconstr Surg. Jul 2005;116(1):200-4. [Medline].

Previous
Next
 
 
 
 
All material on this website is protected by copyright, Copyright © 1994-2012 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

DISCLAIMER: The content of this Website is not influenced by sponsors. The site is designed primarily for use by qualified physicians and other medical professionals. The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for educational and informational purposes only. In no way should it be considered as offering medical advice. Please check with a physician if you suspect you are ill.