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Pediatric Bocavirus Treatment & Management

  • Author: Nicholas John Bennett, MBBCh, PhD, MA(Cantab), FAAP; Chief Editor: Russell W Steele, MD  more...
 
Updated: Mar 03, 2014
 

Medical Care

Acute respiratory illness due to bocavirus should be managed in a manner similar to most other viral respiratory infections.

  • No antiviral medication is known to affect human bocavirus, and none has been proven to be of any clinical benefit.
  • Symptomatic care is the mainstay of treatment.
  • Supplemental oxygen may be required for serious infections that lead to pneumonia.
  • Wheezing may be treated with bronchodilators. However, for wheezing episodes due to bronchiolitis in patients with respiratory syncytial virus infection, bronchodilators are of minimal benefit. The same may be true for human bocavirus; however, a therapeutic trial should probably be considered if the patient is in respiratory distress.

Acute gastroenteritis due to HBoV2 should be managed as with other viral gastrointestinal infections.

  • Replacement of fluid losses, both acute and ongoing
  • Management of any electrolyte disturbances, such as sodium or potassium
 
 
Contributor Information and Disclosures
Author

Nicholas John Bennett, MBBCh, PhD, MA(Cantab), FAAP Assistant Professor of Pediatrics, Co-Director of Antimicrobial Stewardship, Medical Director, Division of Pediatric Infectious Diseases and Immunology, Connecticut Children's Medical Center

Nicholas John Bennett, MBBCh, PhD, MA(Cantab), FAAP is a member of the following medical societies: Alpha Omega Alpha, American Academy of Pediatrics

Disclosure: Received research grant from: Cubist Pharmaceuticals, Durata Therapeutics, and Biota Pharmaceutical<br/>Received income in an amount equal to or greater than $250 from: HealthyCT insurance<br/>Medico legal consulting for: Various.

Coauthor(s)

Joseph Domachowske, MD Professor of Pediatrics, Microbiology and Immunology, Department of Pediatrics, Division of Infectious Diseases, State University of New York Upstate Medical University

Joseph Domachowske, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Pediatrics, American Society for Microbiology, Infectious Diseases Society of America, Pediatric Infectious Diseases Society, Phi Beta Kappa

Disclosure: Received research grant from: Pfizer;GlaxoSmithKline;AstraZeneca;Merck;American Academy of Pediatrics<br/>Received income in an amount equal to or greater than $250 from: Sanofi Pasteur;Astra Zeneca;Novartis<br/>Consulting fees for: Sanofi Pasteur; Novartis; Merck; Astra Zeneca.

Specialty Editor Board

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Joseph Domachowske, MD Professor of Pediatrics, Microbiology and Immunology, Department of Pediatrics, Division of Infectious Diseases, State University of New York Upstate Medical University

Joseph Domachowske, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Pediatrics, American Society for Microbiology, Infectious Diseases Society of America, Pediatric Infectious Diseases Society, Phi Beta Kappa

Disclosure: Received research grant from: Pfizer;GlaxoSmithKline;AstraZeneca;Merck;American Academy of Pediatrics<br/>Received income in an amount equal to or greater than $250 from: Sanofi Pasteur;Astra Zeneca;Novartis<br/>Consulting fees for: Sanofi Pasteur; Novartis; Merck; Astra Zeneca.

Chief Editor

Russell W Steele, MD Clinical Professor, Tulane University School of Medicine; Staff Physician, Ochsner Clinic Foundation

Russell W Steele, MD is a member of the following medical societies: American Academy of Pediatrics, American Association of Immunologists, American Pediatric Society, American Society for Microbiology, Infectious Diseases Society of America, Louisiana State Medical Society, Pediatric Infectious Diseases Society, Society for Pediatric Research, Southern Medical Association

Disclosure: Nothing to disclose.

References
  1. Allander T, Tammi MT, Eriksson M, et al. Cloning of a human parvovirus by molecular screening of respiratory tract samples. Proc Natl Acad Sci U S A. 2005 Sep 6. 102(36):12891-6. [Medline].

  2. Schildgen O, Müller A, Allander T, Mackay IM, Völz S, Kupfer B, et al. Human bocavirus: passenger or pathogen in acute respiratory tract infections?. Clin Microbiol Rev. 2008 Apr. 21(2):291-304, table of contents. [Medline]. [Full Text].

  3. Kapoor A, Slikas E, Simmonds P, Chieochansin T, Naeem A, Shaukat S, et al. A newly identified bocavirus species in human stool. J Infect Dis. 2009 Jan 15. 199(2):196-200. [Medline]. [Full Text].

  4. Chow BD, Ou Z, Esper FP. Newly recognized bocaviruses (HBoV, HBoV2) in children and adults with gastrointestinal illness in the United States. J Clin Virol. 2010 Feb. 47(2):143-7. [Medline].

  5. Arthur JL, Higgins GD, Davidson GP, Givney RC, Ratcliff RM. A novel bocavirus associated with acute gastroenteritis in Australian children. PLoS Pathog. 2009 Apr. 5(4):e1000391. [Medline]. [Full Text].

  6. Dijkman R, Koekkoek SM, Molenkamp R, Schildgen O, van der Hoek L. Human bocavirus can be cultured in differentiated human airway epithelial cells. J Virol. 2009 Aug. 83(15):7739-48. [Medline]. [Full Text].

  7. Lassauniére R, Kresfelder T, Venter M. A novel multiplex real-time RT-PCR assay with FRET hybridization probes for the detection and quantitation of 13 respiratory viruses. J Virol Methods. 2010 Feb 11. [Medline].

  8. Allander T, Jartti T, Gupta S, et al. Human bocavirus and acute wheezing in children. Clin Infect Dis. 2007 Apr 1. 44(7):904-10. [Medline].

  9. Fry AM, Lu X, Chittaganpitch M, Peret T, et al. Human bocavirus: a novel parvovirus epidemiologically associated with pneumonia requiring hospitalization in Thailand. J Infect Dis. 2007 Apr 1. 195(7):1038-45. [Medline].

  10. Martin ET, Fairchok MP, Kuypers J, et al. Frequent and prolonged shedding of bocavirus in young children attending daycare. J Infect Dis. 2010 Jun 1. 201(11):1625-32. [Medline]. [Full Text].

  11. Lehtoranta L, Soderlund-Venermo M, Nokso-Koivisto J, et al. Human bocavirus in the nasopharynx of otitis-prone children. Int J Pediatr Otorhinolaryngol. 2012 Feb. 76(2):206-11. [Medline].

  12. Blessing K, Neske F, Herre U, Kreth HW, Weissbrich B. Prolonged detection of human bocavirus DNA in nasopharyngeal aspirates of children with respiratory tract disease. Pediatr Infect Dis J. 2009 Nov. 28(11):1018-9. [Medline].

  13. Deng Y, Gu X, Zhao X, et al. High viral load of human bocavirus correlates with duration of wheezing in children with severe lower respiratory tract infection. PLoS One. 2012. 7(3):e34353. [Medline]. [Full Text].

  14. Korner RW, Soderlund-Venermo M, van Koningsbruggen-Rietschel S, Kaiser R, Malecki M, Schildgen O. Severe human bocavirus infection, Germany. Emerg Infect Dis. 2011 Dec. 17(12):2303-5. [Medline]. [Full Text].

  15. Edner N, Castillo-Rodas P, Falk L, Hedman K, Söderlund-Venermo M, Allander T. Life-threatening respiratory tract disease with human bocavirus-1 infection in a 4-year-old child. J Clin Microbiol. 2012 Feb. 50(2):531-2. [Medline]. [Full Text].

  16. Mitui MT, Tabib SM, Matsumoto T, et al. Detection of human bocavirus in the cerebrospinal fluid of children with encephalitis. Clin Infect Dis. 2012 Apr. 54(7):964-7. [Medline].

  17. Korppi M. Polymerase chain reaction in respiratory samples alone is not a reliable marker of bocavirus infection. Pediatr Pulmonol. 2013 Oct 24. [Medline].

  18. Brebion A, Vanlieferinghen P, Déchelotte P, Boutry M, Peigue-Lafeuille H, Henquell C. Fatal sub-acute myocarditis associated with human bocavirus 2 in a 13-month-old child. J Clin Microbiol. 2013 Dec 26. [Medline].

  19. Mori D, Ranawaka U, Yamada K, Rajindrajith S, Miya K, Perera HK, et al. Human bocavirus in patients with encephalitis, Sri Lanka, 2009-2010. Emerg Infect Dis. 2013 Nov. 19(11):1859-62. [Medline]. [Full Text].

  20. Endo R, Ishiguro N, Kikuta H, Teramoto S, Shirkoohi R, Ma X, et al. Seroepidemiology of human bocavirus in Hokkaido prefecture, Japan. J Clin Microbiol. 2007 Oct. 45(10):3218-23. [Medline].

  21. Vicente D, Cilla G, Montes M, et al. Human bocavirus, a respiratory and enteric virus. Emerg Infect Dis. 2007 Apr. 13(4):636-7. [Medline].

  22. Ma X, Endo R, Ishiguro N, et al. Detection of human bocavirus in Japanese children with lower respiratory tract infections. J Clin Microbiol. 2006 Mar. 44(3):1132-4. [Medline].

  23. Volz S, Schildgen O, Klinkenberg D, et al. Prospective study of Human Bocavirus (HBoV) infection in a pediatric university hospital in Germany 2005/2006. J Clin Virol. 2007 Nov. 40(3):229-35. [Medline].

  24. Kapoor A, Simmonds P, Slikas E, et al. Human bocaviruses are highly diverse, dispersed, recombination prone, and prevalent in enteric infections. J Infect Dis. 2010 Jun 1. 201(11):1633-43. [Medline].

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The genome of human bocavirus. The 4 genes are labeled based on their presumed function, according to homologous genes in other parvoviruses. Nonstructural protein 1 (NS1) is a DNA-binding protein involved in gene transcription. NP1 is also nonstructural and is a highly conserved protein of unknown function. The capsid proteins are viral protein 1 (VP1) and viral protein 2 (VP2).
An electron micrograph of canine parvovirus, which is closely related to human bocavirus.
 
 
 
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