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Bocavirus Clinical Presentation

  • Author: Kavipriya Umapathy, MBChB; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
Updated: Dec 17, 2014


Dina et al (2009) reported that the main symptoms of human bocavirus (HBoV) infection in children include rhinitis, cough, dyspnea, wheezing, fever, and diarrhea.[24]

Symptoms of bocavirus infection in adults mimic those of atypical pneumonia, bronchitis, or acute exacerbations of chronic bronchitis in the respiratory tract and those of other causes of acute gastroenteritis in the gastrointestinal tract.

Human bocavirus is an emerging human parvovirus, and the full spectrum of disease associated with the virus remains to be seen.



Findings of bocavirus infection are similar to those of a typical viral respiratory illness or atypical pneumonia, including the following:

  • Fever
  • Rhinorrhea
  • Pertussislike cough
  • Wheezing
  • Tachypnea
  • Grunting
  • Accessory muscle use

In patients with acute bocavirus-associated gastroenteritis, findings may include the following:

  • Decreased perfusion with increased capillary refill time
  • Orthostatic changes
  • Minimal abdominal tenderness
  • Other signs associated with dehydration
Contributor Information and Disclosures

Kavipriya Umapathy, MBChB Resident Physician, Department of Pediatrics, UCSF Fresno, Department of Pediatrics, St Peter's University Hospital

Kavipriya Umapathy, MBChB is a member of the following medical societies: American Academy of Pediatrics

Disclosure: Nothing to disclose.


Ted Louie, MD, FACP Clinical Associate Professor of Medicine, Rutgers New Jersey Medical School; Adjunct Clinical Associate Professor of Medicine, Drexel University College of Medicine; Partner, Highland Park Medical Associates

Ted Louie, MD, FACP is a member of the following medical societies: American College of Physicians, American Medical Association, Infectious Diseases Society of America

Disclosure: Nothing to disclose.

Specialty Editor Board

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Chief Editor

Pranatharthi Haran Chandrasekar, MBBS, MD Professor, Chief of Infectious Disease, Program Director of Infectious Disease Fellowship, Department of Internal Medicine, Wayne State University School of Medicine

Pranatharthi Haran Chandrasekar, MBBS, MD is a member of the following medical societies: American College of Physicians, American Society for Microbiology, International Immunocompromised Host Society, Infectious Diseases Society of America

Disclosure: Nothing to disclose.

Additional Contributors

Mary D Nettleman, MD, MS MACP, Professor and Chair, Department of Medicine, Michigan State University College of Human Medicine

Mary D Nettleman, MD, MS is a member of the following medical societies: American College of Physicians, Association of Professors of Medicine, Central Society for Clinical and Translational Research, Infectious Diseases Society of America, Society of General Internal Medicine

Disclosure: Nothing to disclose.

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The genome of human bocavirus. The 4 genes are labeled based on their presumed function, according to homologous genes in other parvoviruses. Nonstructural protein 1 (NS1) is a DNA-binding protein involved in gene transcription. NP1 is also nonstructural and is a highly conserved protein of unknown function. The capsid proteins are viral protein 1 (VP1) and viral protein 2 (VP2).
Illustration of an electron micrograph of canine parvovirus, which is closely related to human bocavirus.
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