Benign Neonatal Sleep Myoclonus Workup
- Author: Marc P DiFazio, MD; Chief Editor: Ted Rosenkrantz, MD more...
Laboratory Studies
If jitteriness or tetany remain in the differential diagnosis, screening for hypoglycemia and electrolyte disturbances is indicated.
Imaging Studies
Once benign neonatal sleep myoclonus (BNSM) is identified, no imaging studies are indicated. If epilepsy or seizures remain a concern, MRI is the study of choice in infants.
Other Tests
If seizures remain a consideration, performing EEG is appropriate. Prolonged EEG monitoring, during multiple sleep/wake cycles potentially allows for time-locked data collection during episodes, making this the optimal study for infants in whom diagnostic confusion remains.
Coulter DL, Allen RJ. Benign neonatal sleep myoclonus. Arch Neurol. Mar 1982;39(3):191-2. [Medline].
Di Capua M, Fusco L, Ricci S, et al. Benign neonatal sleep myoclonus: clinical features and video-polygraphic recordings. Mov Disord. Apr 1993;8(2):191-4. [Medline].
Caviness JN, Brown P. Myoclonus: current concepts and recent advances. Lancet Neurol. Oct 2004;3(10):598-607. [Medline].
Maurer VO, Rizzi M, Bianchetti MG, Ramelli GP. Benign neonatal sleep myoclonus: a review of the literature. Pediatrics. Apr 2010;125(4):e919-24. [Medline].
Welsh JP, Placantonakis DG, Warsetsky SI, et al. The serotonin hypothesis of myoclonus from the perspective of neuronal rhythmicity. Adv Neurol. 2002;89:307-29. [Medline].
Resnick TJ, Moshe SL, Perotta L, et al. Benign neonatal sleep myoclonus. Relationship to sleep states. Arch Neurol. Mar 1986;43(3):266-8. [Medline].
Parmelee AH Jr. Sleep cycles in infants. Dev Med Child Neurol. Dec 1969;11(6):794-5. [Medline].
Daoust-Roy J, Seshia SS. Benign neonatal sleep myoclonus. A differential diagnosis of neonatal seizures. Am J Dis Child. Oct 1992;146(10):1236-41. [Medline].
Egger J, Grossmann G, Auchterlonie IA. Benign sleep myoclonus in infancy mistaken for epilepsy. BMJ. May 3 2003;326(7396):975-6. [Medline].
Ramelli GP, Sozzo AB, Vella S, et al. Benign neonatal sleep myoclonus: an under-recognized, non-epileptic condition. Acta Paediatr. Jul 2005;94(7):962-3. [Medline].
Paro-Panjan D, Neubauer D. Benign neonatal sleep myoclonus: experience from the study of 38 infants. Eur J Paediatr Neurol. Jan 2008;12(1):14-8. [Medline].
Tinuper P, Bisulli F, Provini F, Montagna P, Lugaresi E. Nocturnal Frontal Lobe Epilepsy: new pathophysiological interpretations. Sleep Med. Dec 2011;12 Suppl 2:S39-42. [Medline].
Scher MS. Pathologic myoclonus of the newborn: electrographic and clinical correlations. Pediatr Neurol. Nov-Dec 1985;1(6):342-8. [Medline].
Cohen R, Shuper A, Straussberg R. Familial benign neonatal sleep myoclonus. Pediatr Neurol. May 2007;36(5):334-7. [Medline].
Vaccario ML, Valenti MA, Carullo A, et al. Benign neonatal sleep myoclonus: case report and follow-up of four members of an affected family. Clin Electroencephalogr. Jan 2003;34(1):15-7. [Medline].
Turanli G, Senbil N, Altunbasak S, et al. Benign neonatal sleep myoclonus mimicking status epilepticus. J Child Neurol. Jan 2004;19(1):62-3. [Medline].
Crossman AR, Sambrook MA, Jackson A. Experimental hemichorea/hemiballismus in the monkey. Studies on the intracerebral site of action in a drug-induced dyskinesia. Brain. Jun 1984;107 (Pt 2):579-96. [Medline].
Sanchez RM, Jensen FE. Maturational aspects of epilepsy mechanisms and consequences for the immature brain. Epilepsia. May 2001;42(5):577-85. [Medline].
Alfonso I, Papazian O, Aicardi J, et al. A simple maneuver to provoke benign neonatal sleep myoclonus. Pediatrics. Dec 1995;96(6):1161-3. [Medline].
Ramelli GP, Sozzo AB, Vella S, et al. Benign neonatal sleep myoclonus: an under-recognized, non-epileptic condition. Acta Paediatr. Jul 2005;94(7):962-3. [Medline].
American Academy of Sleep Medicine. American Academy of Sleep Medicine. International Classification of Sleep Disorders, revised: Diagnostic and Coding Manual. 2nd ed. Chicago, IL: 2001:211-2.
Nolte R. Neonatal sleep myoclonus followed by myoclonic-astatic epilepsy: a case report. Epilepsia. Nov-Dec 1989;30(6):844-50. [Medline].
Symonds CP. Nocturnal myoclonus. J Neurol Neurosurg Psychiatry. Aug 1953;16(3):166-71. [Medline].
Oswald I. Sudden bodily jerks on falling asleep. Brain. Mar 1959;82(1):92-103. [Medline].

