eMedicine Specialties > Allergy and Immunology > Major Allergic Diseases

Food Allergies: Treatment & Medication

Author: Scott H Sicherer, MD, Associate Professor of Pediatrics, Mount Sinai School of Medicine of New York University
Contributor Information and Disclosures

Updated: Sep 2, 2009

Treatment

Medical Care

  • Education
    • Education is of paramount importance for patients with food allergies.
    • Patients can obtain useful resource information by contacting the Food Allergy and Anaphylaxis Network (toll-free phone number is 800-929-4040).
    • Remember that appropriate restriction and complete avoidance of the relevant food allergen or allergens is the only current effective therapy.
  • Elimination of food allergen
    • Once a food allergy is diagnosed, strict elimination of the offending food allergen from the diet and avoidance of any contact with the food by ingestion, skin contact, inhalation, or injection is necessary.
    • Elimination and strict avoidance is the only proven medical therapy for this allergic disease.
  • Recognize the early signs and symptoms of an allergic reaction. Keep in mind that cutaneous, gastrointestinal, and respiratory symptoms are the most common clinical manifestations of food allergy.

Consultations

  • Consultation with a board-certified allergist/immunologist should be considered when food allergy is suspected or confirmed.
  • Consultation with a nutritionist or nutrition service is invaluable in the overall management. The elimination diet can be reviewed and appropriate substitutions can be recommended. Dietary deficiencies can be anticipated and prevented.
  • Consultation with a gastroenterologist is also useful in the evaluation of selected patients. For example, patients who present with possible anatomic gastrointestinal abnormalities, eosinophilic esophagitis or gastroenteritis, failure to thrive, and malabsorption syndromes may benefit from consultation with both an allergist and a gastroenterologist.

Diet

  • A properly managed well-balanced elimination diet (eg, allergen restriction) can lead to resolution of symptoms and help avoid nutritional deficiencies.
  • Educate the patient and family about how to properly read food labels and identify common words used for indicating the presence of the food allergen of concern.
  • US labeling laws now require major allergens (ie, egg, milk, wheat, soy, peanut, tree nuts, fish, crustacean shellfish) to be identified as ingredients on manufactured food products using plain English terms. Note that not all potential allergens are included and that some may be subsumed under terms such as s pices or natural flavor.
  • Advisory labels (eg, may contain) are not regulated, are voluntary, and may reflect variable risks.
  • Meal preparation must consider avoidance of crosscontact (eg, shared utensils, fryers) of allergens with otherwise safe foods.
  • With elimination diets, only exclude those foods confirmed to provoke allergic reactions.
  • Review obvious and hidden sources of food allergens. Be aware of the potential for exposures by routes other than ingestion, such as skin contact, or inhalation. This concern is particularly problematic for foods while they are being cooked and proteins are dispersed in the steam (eg, frying fish, boiling milk). Educate about the potential for food allergens to be present in medications and cosmetics.
  • Anticipate potential candidates for food allergen crossreactivity, such as the following:7
    • Eggs and chicken (<5%)
    • Cow milk and beef (10%)
    • Cow milk and goat milk (>90%)
    • Fish (>50%)
    • Peanuts and related legumes (<10%)
    • Soy and related legumes (<5%)
    • Wheat and other grains (25%)
    • Tree nuts and other nuts (>50%)
  • Encourage avoidance of high-risk situations (eg, buffets, picnics), where accidental or inadvertent ingestion of food allergens can occur.
  • Instruct patients to discuss their food allergies with restaurant and food establishment personnel.

Medication

Despite following stringent avoidance measures for clinically relevant food allergens, accidental or inadvertent ingestions may occur. Therefore, patients must be instructed on actions to take in the event of a reaction. For persons with a potentially severe food allergy, prescription of self-injectable epinephrine is advised.26

A concise written plan for the treatment of allergic reactions resulting from accidental exposure to the food should be developed. Examples of such a plan can be downloaded from www.foodallergy.org. For patients with a history of a mild reaction, such as urticaria and pruritus following the ingestion of a food allergen, treatment may be limited to an oral antihistamine. However, the potential for a more severe reaction on subsequent exposures must be taken into consideration because of the possibility of the ingestion of a larger dose than previously ingested or an unexpected or unrecognized increase in the patient’s degree of sensitivity.

If the patient has significant systemic symptoms, the treatment of choice is epinephrine administered by intramuscular injection in the lateral thigh.58 Examples of systemic manifestations of food allergy include generalized urticaria, laryngeal edema, lower respiratory symptoms (eg, chest tightness, dyspnea, wheezing), and hypotension. Epinephrine should likely be administered to any patient with history of a severe allergic reaction as soon as ingestion of the food allergen is discovered and the first symptoms appear, possibly even before symptoms appear.

Patient must be educated regarding when to use their self-injector and the proper technique. They should be instructed to obtain immediate medical assistance (eg, call 911) in the event of anaphylaxis.

Epinephrine is the primary medication indicated to treat anaphylaxis. Patients should not depend upon bronchodilators or antihistamines to treat anaphylaxis, though these can be used as additional therapies.59 For more information on the treatment of anaphylaxis, please see eMedicine article Anaphylaxis.

Caregivers of children should be instructed on identification and treatment of allergic and anaphylactic reactions.

Additional therapy during an allergic reaction includes antihistamines. A bronchodilator may be used as an adjunctive therapy for asthma. Although corticosteroids are often given for anaphylaxis, they are not believed to alter the early symptoms; theoretically, they may reduce late symptoms.

Advanced medical therapy of food allergen–induced anaphylaxis may include antihistamines; bronchodilators; histamine 2 (h2) blockers; corticosteroids; administration of intravenous fluids, glucagon, and oxygen; as well as ventilatory and circulatory support in severe anaphylaxis.

Adrenergic agonists

Used in the emergency management of systemic allergic reactions or anaphylaxis (eg, urticaria, angioedema, bronchospasm, cardiovascular collapse). Effects are immediate and dramatic. Appropriate use of this class of medication can be lifesaving, especially in the emergency management of anaphylaxis.


Epinephrine (Adrenaline, EpiPen, TwinJect)

DOC for treating anaphylaxis. Helps decrease symptoms of anaphylaxis by increasing systemic vascular resistance, elevating diastolic pressure, producing bronchodilation, and increasing inotropic and chronotropic cardiac activity. In addition, helps reduce urticaria, angioedema, laryngeal edema, and other systemic manifestations of anaphylaxis.

Adult

0.3 mL IM (also traditionally given SC) of 1:1000 aqueous injected (usual range is 0.2-0.5 mL) q10-15min, not to exceed 3 doses; may need to decrease dose to 0.2 mL in elderly persons or those with known cardiac conditions
0.3 mL IM of 1:1000 dilution q10-15min; IV route (1:10,000) seldom used; not to exceed 0.25 mg; given very slowly and with extreme caution
0.3-mg self-injectable devices (EpiPen, Twinject 0.3 mg)

Pediatric

IM dosing in children based on weight or 0.01 mL/kg IM of 1:1000 dilution; not to exceed 0.3 mL IM 1:2000 dilution q10-15min
0.15-mg self-injectable devices (EpiPen Jr, Twinject 0.15 mg)

Increases toxicity of beta- and alpha-blocking agents and that of halogenated inhalational anesthetics, ie, drugs that may sensitize the heart to arrhythmias

Documented hypersensitivity; cardiac arrhythmias, coronary artery insufficiency, or angle-closure glaucoma; local anesthesia in areas such as fingers or toes because vasoconstriction may produce sloughing of tissue; do not use during labor (may delay second stage of labor)

Pregnancy

C - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits outweigh risk to fetus

Precautions

Dose may be decreased in elderly patients to 0.2 mL; may cause disturbing reactions such as fear, anxiety, tenseness, restlessness, throbbing headache, weakness, dizziness, pallor, respiratory difficulty, palpitation, tachycardia, tremor, and arrhythmia; use with caution in patients with cardiovascular disease, hyperthyroidism, and diabetes; properly train patients with use of self-injectable devices; advise patients to seek medical attention if using self-injectable devices to manage allergic reactions

More on Food Allergies

Overview: Food Allergies
Differential Diagnoses & Workup: Food Allergies
Treatment & Medication: Food Allergies
Follow-up: Food Allergies
References

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Further Reading

Keywords

food allergies, food allergy, adverse immunologic reactions to foods, allergic reactions to foods, food hypersensitivity, food intolerance, food allergy test, food allergy symptoms, food allergy rash, food allergy treatment, allergy foods, adverse food reactions, lactose intolerance, bacterial food poisoning, peanut allergy, protein-induced enterocolitis syndrome, proctocolitis, food hypersensitivity, allergen exposure, anaphylactic reactions, food-induced anaphylactic reaction, oral allergy syndrome, dietary protein enterocolitis, food-induced asthma, food-induced pulmonary hemosiderosis, Heiner syndrome, egg allergy, milk allergy, peanut allergy, soy allergy, fish allergy, shellfish allergy, tree nut allergy, wheat allergy, celiac disease, childhood food allergy, lactose intolerant

Contributor Information and Disclosures

Author

Scott H Sicherer, MD, Associate Professor of Pediatrics, Mount Sinai School of Medicine of New York University
Scott H Sicherer, MD is a member of the following medical societies: American Academy of Allergy Asthma and Immunology and American Academy of Pediatrics
Disclosure: Nothing to disclose.

Medical Editor

Stephen C Dreskin, MD, PhD, Director of Allergy, Asthma, and Immunology Practice, Professor of Medicine, Departments of Internal Medicine and Immunology, University of Colorado Health Sciences Center
Stephen C Dreskin, MD, PhD is a member of the following medical societies: American Academy of Allergy Asthma and Immunology, American Association for the Advancement of Science, American Association of Immunologists, American Association of Neuropathologists, American Association of Ophthalmic Pathologists, American Association of Oral and Maxillofacial Surgeons, American College of Allergy, Asthma and Immunology, Clinical Immunology Society, and Joint Council of Allergy, Asthma and Immunology
Disclosure: Genentech Consulting fee Consulting

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: eMedicine Salary Employment

Managing Editor

Stephen C Dreskin, MD, PhD, Director of Allergy, Asthma, and Immunology Practice, Professor of Medicine, Departments of Internal Medicine and Immunology, University of Colorado Health Sciences Center
Stephen C Dreskin, MD, PhD is a member of the following medical societies: American Academy of Allergy Asthma and Immunology, American Association for the Advancement of Science, American Association of Immunologists, American Association of Neuropathologists, American Association of Ophthalmic Pathologists, American Association of Oral and Maxillofacial Surgeons, American College of Allergy, Asthma and Immunology, Clinical Immunology Society, and Joint Council of Allergy, Asthma and Immunology
Disclosure: Genentech Consulting fee Consulting

CME Editor

Timothy D Rice, MD, Associate Professor, Departments of Internal Medicine and Pediatrics and Adolescent Medicine, Saint Louis University School of Medicine
Timothy D Rice, MD is a member of the following medical societies: American Academy of Pediatrics and American College of Physicians
Disclosure: Nothing to disclose.

Chief Editor

Michael A Kaliner, MD, Clinical Professor of Medicine, George Washington University School of Medicine; Chief, Section of Allergy and Immunology, Washington Hospital Center; Medical Director, Institute for Asthma and Allergy
Michael A Kaliner, MD is a member of the following medical societies: American Academy of Allergy Asthma and Immunology, American Association of Immunologists, American College of Allergy, Asthma and Immunology, American Society for Clinical Investigation, American Thoracic Society, and Association of American Physicians
Disclosure: Abbott Consulting fee Consulting; Alcon Consulting fee Consulting; Glaxo Consulting fee Consulting; Greer Consulting fee Consulting; Sanofi Consulting fee Consulting; Schering Consulting fee Consulting; Teva  Consulting; Meda Honoraria Speaking and teaching

 
 
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