Medscape is available in 5 Language Editions – Choose your Edition here.


Delayed Hypersensitivity Reactions Medication

  • Author: Stuart L Abramson, MD, PhD; Chief Editor: Michael A Kaliner, MD  more...
Updated: Dec 23, 2015

Medication Summary

Medical treatment differs greatly depending on the specific disease entity. Only a few medications are discussed. In addition to drugs mentioned below, a drug that may augment cell-mediated immunity is cimetidine, which is an H2 receptor blocker that acts as a reverse antagonist and may augment cell-mediated immunity.[9]



Class Summary

Have anti-inflammatory properties and cause profound and varied metabolic effects. Modify the body's immune response to diverse stimuli.

Triamcinolone (Aristocort)


Helps treat inflammatory dermatosis responsive to steroids. Decreases inflammation by suppressing migration of PMN leukocytes and reversing capillary permeability.

Mometasone (Elocon)


May depress formation, release, and activity of endogenous chemical mediators of inflammation.

Prednisone (Deltasone, Orasone, Meticorten, Sterapred)


May decrease inflammation by reversing increased capillary permeability and suppressing PMN activity.

Contributor Information and Disclosures

Stuart L Abramson, MD, PhD Associate Professor of Pediatrics, Baylor College of Medicine; Consulting Staff, Allergy/Immunology Section, Texas Children's Hospital

Disclosure: Nothing to disclose.

Specialty Editor Board

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Michael R Simon, MD, MA Clinical Professor Emeritus, Departments of Internal Medicine and Pediatrics, Wayne State University School of Medicine; Professor, Department of Internal Medicine, Oakland University William Beaumont University School of Medicine; Adjunct Staff, Division of Allergy and Immunology, Department of Internal Medicine, William Beaumont Hospital

Michael R Simon, MD, MA is a member of the following medical societies: American Academy of Allergy Asthma and Immunology, American College of Allergy, Asthma and Immunology, Michigan State Medical Society, Michigan Allergy and Asthma Society, American College of Physicians, American Federation for Medical Research, Royal College of Physicians and Surgeons of Canada, Society for Experimental Biology and Medicine

Disclosure: Received ownership interest from Secretory IgA, Inc. for management position; Received ownership interest from siRNAx, Inc. for management position.

Chief Editor

Michael A Kaliner, MD Clinical Professor of Medicine, George Washington University School of Medicine; Medical Director, Institute for Asthma and Allergy

Michael A Kaliner, MD is a member of the following medical societies: American Academy of Allergy Asthma and Immunology, American Association of Immunologists, American College of Allergy, Asthma and Immunology, American Society for Clinical Investigation, American Thoracic Society, Association of American Physicians

Disclosure: Nothing to disclose.

Additional Contributors

Melvin Berger, MD, PhD Adjunct Professor of Pediatrics and Pathology, Case Western Reserve University; Senior Medical Director, Clinical Research and Development, CSL Behring, LLC

Melvin Berger, MD, PhD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Allergy Asthma and Immunology, American Academy of Pediatrics, American Association of Immunologists, American Pediatric Society, American Society for Clinical Investigation, Clinical Immunology Society

Disclosure: Received salary from CSL Behring for employment; Received ownership interest from CSL Behring for employment; Received consulting fee from America''s Health insurance plans for subject matter expert for clinical immunization safety assessment network acvtivity of cdc.


The authors and editors of Medscape Reference gratefully acknowledge the contributions of previous authors Walter Duane Hinshaw, DO; Gregory Paul Neyman, MD; and Stephen Mark Olmstead, DO; to the development and writing of this article.

  1. Malajian D, Belsito DV. Cutaneous delayed-type hypersensitivity in patients with atopic dermatitis. J Am Acad Dermatol. 2013 Apr 11. [Medline].

  2. Olivier C. [Intradermal tuberculin test]. Arch Pediatr. 2000 Jun. 7 Suppl 3:559s-564s. [Medline].

  3. Bansal R, Sharma PK. Exaggerated Mantoux reaction in a case of latent tuberculosis infection (LTBI). Indian J Tuberc. 2012 Jul. 59(3):171-3. [Medline].

  4. Facktor MA, Bernstein RA, Fireman P. Hypersensitivity to tetanus toxoid. J Allergy Clin Immunol. 1973 Jul. 52(1):1-12. [Medline].

  5. Chadha VK. Tuberculin test. Indian J Pediatr. 2001 Jan. 68(1):53-8. [Medline].

  6. Rigouts L. Clinical practice : Diagnosis of childhood tuberculosis. Eur J Pediatr. 2009 Apr 25. [Medline].

  7. Wilson JD. Skin testing in the assessment of cell-mediated immunity. N Z Med J. 1977 Jan 26. 85(580):41-4. [Medline].

  8. Wander K, Shell-Duncan B, Brindle E, O'Connor K. Predictors of delayed-type hypersensitivity to Candida albicans and anti-epstein-barr virus antibody among children in Kilimanjaro, Tanzania. Am J Phys Anthropol. 2013 Mar 4. [Medline].

  9. Jorizzo JL, Sams WM, Jegasothy BV, Olansky AJ. Cimetidine as an immunomodulator: chronic mucocutaneous candidiasis as a model. Ann Intern Med. 1980 Feb. 92(2 Pt 1):192-5. [Medline].

  10. Cohen DE, Brancaccio RR, Soter NA. Diagnostic tests for type IV or delayed hypersensitivity reactions. Clin Allergy Immunol. 2000. 15:287-305. [Medline].

  11. Fauci AJ, Braunwald E, Isselbacher KJ, et al, eds. Harrison's Principles of Internal Medicine. 14th ed. New York, NY: McGraw-Hill; 1998.

  12. Gifford RR, Hatfield SM, Schmidtke JR. Cimetidine-induced augmentation of human lymphocyte blastogenesis by mitogen, bacterial antigen, and alloantigen. Transplantation. 1980 Feb. 29(2):143-8. [Medline].

  13. Goroll AH, May LA, Mulley AG, eds. Primary Care Medicine: Office Evaluation and Management of the Adult Patient. 4th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2000.

  14. Hyman MH. Delayed drug hypersensitivity reactions. Ann Intern Med. 2004 May 4. 140(9):W35; author reply W36. [Medline].

  15. Jacysyn JF, Abrahamsohn IA, Macedo MS. Modulation of delayed-type hypersensitivity during the time course of immune response to a protein antigen. Immunology. 2001 Mar. 102(3):373-9. [Medline].

  16. Jelinek C. Appendix E: Diagnostic Procedures. Delayed Hypersensitivity Skin Testing. Allergy/Immunology Specialist Course Manual. 5th ed. US Army; 1990. E-1-11.

  17. Kusy RP. Clinical response to allergies in patients. Am J Orthod Dentofacial Orthop. 2004 May. 125(5):544-7. [Medline].

  18. Middleton E Jr, Reed CE, Ellis EF, et al, eds. Allergy: Principles and Practice. 5th ed. St. Louis, Mo: Mosby-Year Book; 1998.

  19. Roitt IM. Essential Immunology. 9th ed. Oxford, UK: Blackwell Scientific; 1998. Chapters 22-23.

  20. Simon MR, Salberg DJ, Crane SA. In vivo cimetidine augmentation of phytohemagglutinin-induced human lymphocyte thymidine uptake. Transplantation. 1981 May. 31(5):400-2. [Medline].

  21. Slavin RG, Tennenbaum JI, Becker RJ, et al. Cell transfer of delayed hypersensitivity to ragweed from atopic subjects treated with emulsified ragweed extracts. J Allergy. 1963. 34:368-73.

All material on this website is protected by copyright, Copyright © 1994-2016 by WebMD LLC. This website also contains material copyrighted by 3rd parties.