Chylous Fistula of the Neck

Updated: Aug 18, 2016
  • Author: Philip E Zapanta, MD, FACS; Chief Editor: Arlen D Meyers, MD, MBA  more...
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Overview

Background

Damaging or cutting a thoracic duct while operating low on the left side of the neck does not occur infrequently, even in experienced hands. In fact, transecting the duct when carrying out radical surgery low down in the neck or the mediastinum may often be necessary. What should be avoided, however, is the failure to recognize this complication at the time of surgery, which could lead to serious consequences. [1]

See the image below.

Intraoperative photo of the thoracic duct low in t Intraoperative photo of the thoracic duct low in the neck on the left.
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History of the Procedure

The first description of a cervical chylous fistula was in 1875 by Cheever, followed by Stuart in 1907 with the first review on the condition. At the time, this condition was managed merely with pressure dressings and wound packing, and mortality rates of up to 12.5% for cervical chylous fistula were reported. [2, 3, 4]

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Problem

Chylous fistulas are known to lead to prolonged hospitalization. Clinically, chylous fistulas may be difficult to manage because of significant electrolyte, fluid, and protein abnormalities that are associated.

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Epidemiology

Frequency

Chylous fistula is an infrequent complication of head and neck surgery, with an incidence reported in 1-3% of patients undergoing major neck surgery. [4] This condition has a predilection for the left side of the neck, but up to 25% of cases involve the right side of the neck.

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Etiology

Radical neck dissection is the most frequent operation associated with chylous fistulas, but chylous fistulas may be found after selective neck dissection, penetrating neck trauma, cervical node biopsy, cervical rib resection, anterior neck surgery, and central venous cannulation. [5, 6]

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Pathophysiology

The thoracic duct is the conduit for lymph and dietary fat to reach the venous bloodstream. The flow of chyle is around 2-4 L per day and consists of fat, protein, electrolytes, and lymphocytes. [4, 5, 7, 8] Its daily production is dependent on the diet and daily dietary intake.

Chemical composition of chyle is similar to that of tissue lymph, with higher concentration of cholesterol, phospholipids, and fat particles, particularly triglyceride rich chylomicrons and long-chain (>10 carbon atoms) esterified fats. [9]

The flow of chyle against gravity is supported by the interplay of thoracic and abdominal pressures, the transmission of peristaltic bowel contractions, the contraction of the lymphatic vessels walls, and the Venturi effect at the junction of the thoracic duct and the subclavian vein. [10]

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Presentation

Patients with a chylous fistula present with drainage of "milky white" fluid; however, in patients who are nil by mouth or on a fat-free diet, it may present as a leakage of clear fluid. The volume of drainage ranges from low output (< 500 mL/day) to more than 3 L per day in high-output fistulas. Persistent chyle loss leads to electrolyte disturbance, hypovolemia, hypoalbuminemia, coagulopathy, immunosuppression, chylothorax, peripheral edema, wound infection, and local skin breakdown. Prolonged chyle leak can therefore lead to mortality. [11]

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Indications

Indications for surgical intervention in patients with cervical chylous fistula remain unclear. A chyle leak identified intraoperatively warrants immediate repair. Success of surgery declines in the postoperative period because of fibrosis and the effect chyle has on the soft tissue of the neck. However, failure of medical therapy and radiological intervention advocates neck exploration or ligation of the thoracic duct, particularly in patients with high-output fistulas.

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Relevant Anatomy

The thoracic duct is the largest lymphatic vessel in the body, transporting lymph and chyle from lower limbs, the abdomen, the left hemi thorax, and the left side of the head and neck to venous circulation. It originates anterior to the body of second lumbar vertebra, the cisterna chyli, and ascends, along the right side of vertebral column, through the aortic hiatus of the diagram into the posterior mediastinum, traveling between the aorta and azygous vein towards the fifth thoracic vertebra, where it crosses to the left and continues to ascend up into the neck.

In the neck, the thoracic duct raises 3-5 cm above the clavicle before arching back toward the junction of the left subclavian vein with the left internal jugular vein. Intraoperatively, the thoracic duct can be identified as it courses anterior to the vertebral and thoracocervical vessels between the internal jugular vein and the anterior scalene muscle.

The anatomical variability of its course in the neck makes it susceptible to iatrogenic injury. Cadaveric studies have shown variation of both the site of termination and the number of terminal branches. (See the images below.) [9, 12, 13]

Intraoperative photo of the thoracic duct low in t Intraoperative photo of the thoracic duct low in the neck on the left.
Thoracic duct inserting at the junction of interna Thoracic duct inserting at the junction of internal jugular and subclavian vein in a cadaveric specimen.
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Contraindications

No absolute contraindications to surgical repair of cervical chylous fistula exist.

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