Loeffler Endocarditis Differential Diagnoses

  • Author: Sohail A Hassan, MD; Chief Editor: Richard A Lange, MD, MBA  more...
Updated: Feb 17, 2015

Diagnostic Considerations

Restrictive cardiomyopathies, including cardiac amyloidosis, sarcoidosis, and multiple myeloma, should be ruled out. Other causes of diastolic dysfunction, including hypertensive cardiomyopathy, should be considered in the differential diagnosis. In children, a rare cause of fibrosis and space-occupying lesions is rhabdomyoma, a tumor that has a high degree of association with tuberous sclerosis.

The disease can be missed on endomyocardial biopsy because of patchy infiltration of the myocardium.

Differential Diagnoses

Contributor Information and Disclosures

Sohail A Hassan, MD Cardiologist and Cardiac Electrophysiologist, Eastside Cardiovascular Medicine; Director or Electrophysiology at St John Macomb Hospital; Assistant Professor of Medicine, Wayne State University School of Medicine

Sohail A Hassan, MD is a member of the following medical societies: American College of Cardiology, American College of Physicians, American Heart Association, Michigan State Medical Society, Heart Rhythm Society

Disclosure: Received honoraria from Medtronic, for speaking and teaching; Received honoraria from Zoll for speaking and teaching; Received honoraria from Boeringer Ingelheim for speaking and teaching; Received honoraria from St Jude''''''''s Medical for speaking and teaching; Received honoraria from Boston Scientific corporation for speaking and teaching; Received honoraria from Biotronik for speaking and teaching; Received honoraria from Sanofi Aventis for speaking and teaching.


Henry Kim, MD, MPH Fellowship Director, Department of Cardiology, Henry Ford Hospital

Henry Kim, MD, MPH is a member of the following medical societies: American Medical Association

Disclosure: Nothing to disclose.

Fatima Ansari University of Michigan

Disclosure: Nothing to disclose.

Specialty Editor Board

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Marschall S Runge, MD, PhD Charles and Anne Sanders Distinguished Professor of Medicine, Chairman, Department of Medicine, Vice Dean for Clinical Affairs, University of North Carolina at Chapel Hill School of Medicine

Marschall S Runge, MD, PhD is a member of the following medical societies: American Physiological Society, American Society for Clinical Investigation, American Society for Investigative Pathology, Association of American Physicians, Texas Medical Association, Southern Society for Clinical Investigation, American Federation for Clinical Research, Association of Professors of Medicine, Association of Professors of Cardiology, American Association for the Advancement of Science, American College of Cardiology, American College of Physicians-American Society of Internal Medicine, American Federation for Medical Research, American Heart Association

Disclosure: Received honoraria from Pfizer for speaking and teaching; Received honoraria from Merck for speaking and teaching; Received consulting fee from Orthoclinica Diagnostica for consulting.

Chief Editor

Richard A Lange, MD, MBA President, Texas Tech University Health Sciences Center, Dean, Paul L Foster School of Medicine

Richard A Lange, MD, MBA is a member of the following medical societies: Alpha Omega Alpha, American College of Cardiology, American Heart Association, Association of Subspecialty Professors

Disclosure: Nothing to disclose.


Viqar Maria, MD Resident Physician, Department of Internal Medicine, St John Hospital and Medical Center

Viqar Maria, MD is a member of the following medical societies: American College of Physicians

Disclosure: Nothing to disclose.

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Pathogenesis of Loeffler syndrome.
Myocardial as well as valvular involvement with Loffler endocarditis. This image shows dense fibrosis of ventricle in a postmortem dissected heart.
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