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Ventricular Premature Complexes Treatment & Management

  • Author: Jatin Dave, MD, MPH; Chief Editor: Jeffrey N Rottman, MD  more...
Updated: Dec 30, 2015

Medical Care

Deciding when to treat VPCs is difficult because not all patients with VPCs are at risk of sudden death and treatment is associated with risk. The approach to VPCs depends on the frequency of VPCs, attributable symptoms, the presence or absence of underlying structural heart disease, and the estimated risk of sudden cardiac death.[17]

Absence of significant structural heart disease (eg, normal ventricular function, no coronary or valvular heart disease)

Asymptomatic VPCs require no therapy.

For symptomatic VPCs, recommended treatment usually involves patient education and reassurance, avoidance of aggravating factors (eg, stress, caffeine-containing products), and anxiolytic drugs if education and avoidance of aggravating factors are ineffective. Beta-blockers and nondihydropyridine calcium channel blockers (eg, verapamil, diltiazem) can be used to treat symptomatic patients. Beta-blockers with intrinsic sympathomimetic activity may be particularly helpful.[18, 19]  The use of antiarrhythmic therapy is not typically recommended and best targeted to address limiting symptoms. The risk of the drug (including the risk of arrhythmic death from proarrhythmia) must be weighed against the benefits of VPC suppression.

In patients who are symptomatic on beta-blockers and/or calcium channel blockers, consider cautious use of amiodarone. Because interest in VPC supression decreased when it was shown to be typically deleterious in patients with coronary artery disease, this literature is not current, and specifically the role of newer class III antiarrhythmic like dofetilide and azimilide for VPCs is unclear at present.

Presence of underlying heart disease (eg, VPCs in patients post-MI)

Management in these patients Various strategies, both invasive and noninvasive, predict prognosis in patients with VPCs post-MI.

The most powerful combination of noninvasive prognostic variables that identify patients in whom invasive strategies are suitable includes the presence of 2 or more of the following variables, (1) LV EF less than 0.40, (2) ventricular late potentials (on signal-averaged ECG), and (3) repetitive VPCs.

Supportive management

Treatment should include limiting transient ischemia.

Optimal treatment for congestive heart failure (CHF), CAD, or both should be instituted.

Maintain electrolyte balance.

Blood pressure control should be obtained because LV hypertrophy is associated with increased VPCs.[20]

Ablation therapy

The 2006 ACC/AHA/ESC guideline recommends that ablation therapy should be considered in the following[16] :

  • Patients with frequent, symptomatic, and monomorphic VPCs refractory to medical therapy
  • Patients who choose to avoid long-term medical therapy
  • Patients with ventricular arrhythmia storm that is consistently provoked by VPBs of a similar morphology


Recommendations depend on the underlying cardiac disease; avoidance of caffeine, nicotine, and alcohol may reduce the frequency of VPCs.


Surgical Care

Patients deemed to be at high risk of sudden cardiac death may benefit from implantable cardioverter defibrillator (ICD) implantation.



Consultation with a cardiac electrophysiologist may be beneficial. As described above, select patients with symptomatic idiopathic VPCs may benefit from catheter ablation. EPS may help define risk for sudden death in some patients with structural heart disease. ICD implantation is beneficial in patients at high risk of sudden cardiac death, which is typically assessed by the presence of any associated cardiovascular disease, rather than the presence of VPCs per se.

Contributor Information and Disclosures

Jatin Dave, MD, MPH Part-Time Clinical Instructor, Department of Medicine, Harvard Medical School; Attending Physician, Division of Aging, Department of Medicine, Brigham and Women's Hospital; Medical Director of Geriatrics, Tufts Health Plan

Disclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: Tufts Health Plan, a not for profit organization.

Specialty Editor Board

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Brian Olshansky, MD Professor Emeritus of Medicine, Department of Internal Medicine, University of Iowa College of Medicine

Brian Olshansky, MD is a member of the following medical societies: American College of Cardiology, Heart Rhythm Society, Cardiac Electrophysiology Society, American Heart Association

Disclosure: Received honoraria from Guidant/Boston Scientific for speaking and teaching; Received honoraria from Medtronic for speaking and teaching; Received consulting fee from Guidant/Boston Scientific for consulting; Received consulting fee from BioControl for consulting; Received consulting fee from Boehringer Ingelheim for consulting; Received consulting fee from Amarin for review panel membership; Received consulting fee from sanofi aventis for review panel membership.

Chief Editor

Jeffrey N Rottman, MD Professor of Medicine, Department of Medicine, Division of Cardiovascular Medicine, University of Maryland School of Medicine; Cardiologist/Electrophysiologist, University of Maryland Medical System and VA Maryland Health Care System

Jeffrey N Rottman, MD is a member of the following medical societies: American Heart Association, Heart Rhythm Society

Disclosure: Nothing to disclose.


The authors and editors of Medscape Drugs & Diseases gratefully acknowledge the contributions of previous authors John Michael Gaziano, MD, MPH; Revat Lakhia, MD; and Shivkumar H Jha, MD, to the development and writing of this article.

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Ventricular premature complexes (VPCs). Ventricular trigeminy is present. Note that the VPCs are unimorphic and that a compensatory pause follows each VPC. This patient has asymptomatic idiopathic VPCs originating from the right ventricular outflow tract.
Table 1. Lown Classification
Class Arrhythmia
0 None
1 Unifocal; < 30/h
2 Unifocal; ≥ 30/h
3 Multiform
4A 2 consecutive
4B ≥ 3 consecutive
5 R-on-T phenomenon
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