eMedicine Specialties > Cardiology > Electrophysiology Procedures

Pacemaker Syndrome: Follow-up

Author: Daniel M Beyerbach, MD, PhD,, Consulting Staff, Florida Electrophysiology Associates; Affiliate Clinical Assistant Professor of Biomedical Science, Florida Atlantic University, Regional Campus of University of Miami Miller School of Medicine
Coauthor(s): Christopher Cadman, MD, Director of Arrhythmia Service, Assistant Professor, Department of Internal Medicine, Division of Cardiology, University of New Mexico
Contributor Information and Disclosures

Updated: Nov 13, 2009

Follow-up

Further Inpatient Care

Patients with ventricular pacemakers and pacemaker syndrome may need placement of an additional pacemaker lead. Hospitalize and monitor patients undergoing device or lead implantation for 24 hours after placement surgery.

  • Administer intravenous antibiotics (cefazolin, or vancomycin in patients with beta-lactam allergy) for prophylaxis against skin wound infections.
  • Do not continue intravenous antibiotic therapy for more than 24 hours. If infection develops around the device, it is better detected early in the course in case device explantation is necessary.

Further Outpatient Care

Schedule visits after device or lead implantation as follows: 1-2 weeks for wound check, 1 month for pacemaker interrogation, 3 months for pacemaker interrogation, and every 6 months thereafter for pacemaker interrogation.

Transfer

  • Because diagnosis and treatment require interrogation and reprogramming of pacemaker, patients must be seen in either a clinical or hospital setting in which the appropriate interrogation equipment is available. Each pacemaker manufacturer produces an interrogation computer for its own devices. A major institution will have interrogation computers from several different manufacturers available for use.
  • Some pacemaker manufacturers provide courtesy interrogation services involving site visits for rural populations without easy access to functional facilities.

Deterrence/Prevention

  • Because most cases of pacemaker syndrome occur in the setting of ventricular pacing, institute atrial pacing whenever it is not contraindicated. This includes AAI pacing for most cases of sinus node disease with intact AV nodal conduction. Alternatively, a dual-chamber system can be programmed to a long AV interval to promote intrinsic conduction, provided that the PR interval is not markedly prolonged.
  • Baseline studies by echocardiogram can assess change in cardiac output, stroke volume, and left atrial total emptying fraction in response to ventricular pacing. Examination of these parameters may guide the decision to institute dual-chamber pacing.
  • At time of device implantation, optimize pacing parameters, such as AV delay, PVARP, and rate response slope, for physiologic timing of atrial and ventricular contractions.

Complications

  • Complications of AV dyssynchrony include atrial fibrillation, thromboembolic events, and heart failure.
  • Pacemaker syndrome also can be complicated by syncope or near syncope. Individuals may develop a subjectively worse quality of life with ventricular pacing than they had prior to pacemaker implantation, or they may endure a persistently degraded quality of life, as suggested by Sulke's study of subclinical pacemaker syndrome.
  • Complications of treatment may include the same complications of pacemaker implantation if reimplantation, additional lead placement, or explantation is involved. These complications include infection (4%), pneumothorax (1%), cardiac perforation and tamponade, bleeding, and pain.

Prognosis

Prognosis is excellent with correction of pacing mode.

Patient Education

Educate as in cases of pacemaker implantation in general.

  • Avoid strong electric and magnetic fields. Specifically avoid welding, MRI studies, and proximity to large motors or generators.
  • Use cell phones in ear contralateral to side of device implantation.

Miscellaneous

Medicolegal Pitfalls

In the setting of asymptomatic sinus bradycardia, implantation of a VVI pacemaker may induce symptoms of pacemaker syndrome. Even though this may be a class 2a indication for pacemaker implantation, potential exists for worsening of quality of life.

Special Concerns

As already noted, individuals may develop a subjectively worse quality of life with ventricular pacing than they had prior to pacemaker implantation, or they may endure a persistently degraded quality of life, as suggested by Sulke's study of subclinical pacemaker syndrome.

 


More on Pacemaker Syndrome

Overview: Pacemaker Syndrome
Differential Diagnoses & Workup: Pacemaker Syndrome
Treatment & Medication: Pacemaker Syndrome
Follow-up: Pacemaker Syndrome
Multimedia: Pacemaker Syndrome
References

References

  1. McWilliam JA. Electrical stimulation of the heart in man. Br Med J. 1889;1:348-350.

  2. Alicandri C, Fouad FM, Tarazi RC, et al. Three cases of hypotension and syncope with ventricular pacing: possible role of atrial reflexes. Am J Cardiol. Jul 1978;42(1):137-42. [Medline].

  3. Erbel R. Pacemaker syndrome. Am J Cardiol. Oct 1979;44(4):771-2. [Medline].

  4. Erlebacher JA, Danner RL, Stelzer PE. Hypotension with ventricular pacing: an atria vasodepressor reflex in human beings. J Am Coll Cardiol. Sep 1984;4(3):550-5. [Medline].

  5. Mitsui T, Hori M, Suma K, et al. The "pacemaking syndrome." In: Jacobs JE, ed. Proceedings of the 8th Annual International Conference on Medical and Biological Engineering. Chicago, IL: Association for the Advancement of Medical Instrumentation;. 1969;29-3.

  6. Mitsui T, Mizuno A, Hasegawa T, et al. Atrial rate as an indicator for optimal pacing rate and the pacemaking syndrome. Ann Cardiol Angeiol (Paris). Jul-Aug 1971;20(4):371-9. [Medline].

  7. Furman S. Pacemaker syndrome. Pacing Clin Electrophysiol. Jan 1994;17(1):1-5. [Medline].

  8. Ellenbogen KA, Gilligan DM, Wood MA, et al. The pacemaker syndrome -- a matter of definition. Am J Cardiol. May 1 1997;79(9):1226-9. [Medline].

  9. Gross JN, Keltz TN, Cooper JA, et al. Profound "pacemaker syndrome" in hypertrophic cardiomyopathy. Am J Cardiol. Dec 1 1992;70(18):1507-11. [Medline].

  10. [Guideline] Epstein AE, DiMarco JP, Ellenbogen KA, Estes NA 3rd, Freedman RA, Gettes LS. ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices) developed in collaboration with the American Association for Thoracic Surgery and Society of Thoracic Surgeons. J Am Coll Cardiol. May 27 2008;51(21):e1-62. [Medline].

  11. Lamas GA, Orav EJ, Stambler BS, et al. Quality of life and clinical outcomes in elderly patients treated with ventricular pacing as compared with dual-chamber pacing. Pacemaker Selection in the Elderly Investigators. N Engl J Med. Apr 16 1998;338(16):1097-104. [Medline].

  12. Sulke N, Chambers J, Dritsas A, Sowton E. A randomized double-blind crossover comparison of four rate-responsive pacing modes. J Am Coll Cardiol. Mar 1 1991;17(3):696-706. [Medline].

  13. Hargreaves MR, Channon KM, Cripps TR, et al. Comparison of dual chamber and ventricular rate responsive pacing in patients over 75 with complete heart block. Br Heart J. Oct 1995;74(4):397-402. [Medline].

  14. Oldroyd KG, Rae AP, Carter R, et al. Double blind crossover comparison of the effects of dual chamber pacing (DDD) and ventricular rate adaptive (VVIR) pacing on neuroendocrine variables, exercise performance, and symptoms in complete heart block. Br Heart J. Apr 1991;65(4):188-93. [Medline].

  15. Lee TM, Su SF, Lin YJ, et al. Role of transesophageal echocardiography in the evaluation of patients with clinical pacemaker syndrome. Am Heart J. Apr 1998;135(4):634-40. [Medline].

  16. Theodorakis GN, Kremastinos DT, Markianos M, et al. Total sympathetic activity and atrial natriuretic factor levels in VVI and DDD pacing with different atrioventricular delays during daily activity and exercise. Eur Heart J. Nov 1992;13(11):1477-81. [Medline].

  17. Theodorakis GN, Panou F, Markianos M, et al. Left atrial function and atrial natriuretic factor/cyclic guanosine monophosphate changes in DDD and VVI pacing modes. Am J Cardiol. Feb 1 1997;79(3):366-70. [Medline].

  18. Nishimura RA, Gersh BJ, Vlietstra RE, et al. Hemodynamic and symptomatic consequences of ventricular pacing. Pacing Clin Electrophysiol. Nov 1982;5(6):903-10. [Medline].

  19. Rosenqvist M, Isaaz K, Botvinick EH, et al. Relative importance of activation sequence compared to atrioventricular synchrony in left ventricular function. Am J Cardiol. Jan 15 1991;67(2):148-56. [Medline].

  20. Bordachar P, Lafitte S, Reuter S, et al. Echocardiographic parameters of ventricular dyssynchrony validation in patients with heart failure using sequential biventricular pacing. J Am Coll Cardiol. Dec 7 2004;44(11):2157-65. [Medline].

  21. Ausubel K, Furman S. The pacemaker syndrome. Ann Intern Med. Sep 1985;103(3):420-9. [Medline].

  22. Link MS, Hellkamp AS, Estes NA, et al. High incidence of pacemaker syndrome in patients with sinus node dysfunction treated with ventricular-based pacing in the Mode Selection Trial (MOST). J Am Coll Cardiol. Jun 2 2004;43(11):2066-71. [Medline].

  23. Heldman D, Mulvihill D, Nguyen H, et al. True incidence of pacemaker syndrome. Pacing Clin Electrophysiol. Dec 1990;13(12 Pt 2):1742-50. [Medline].

  24. Sulke N, Dritsas A, Bostock J, et al. "Subclinical" pacemaker syndrome: a randomised study of symptom free patients with ventricular demand (VVI) pacemakers upgraded to dual chamber devices. Br Heart J. Jan 1992;67(1):57-64. [Medline].

  25. Frielingsdorf J, Gerber AE, Hess OM. Importance of maintained atrio-ventricular synchrony in patients with pacemakers. Eur Heart J. Oct 1994;15(10):1431-40. [Medline].

  26. Sutton R, Kenny RA. The natural history of sick sinus syndrome. Pacing Clin Electrophysiol. Nov 1986;9(6 Pt 2):1110-4. [Medline].

  27. Hesselson AB, Parsonnet V, Bernstein AD, Bonavita GJ. Deleterious effects of long-term single-chamber ventricular pacing in patients with sick sinus syndrome: the hidden benefits of dual-chamber pacing. J Am Coll Cardiol. Jun 1992;19(7):1542-9. [Medline].

  28. Santini M, Alexidou G, Ansalone G, et al. Relation of prognosis in sick sinus syndrome to age, conduction defects and modes of permanent cardiac pacing. Am J Cardiol. Mar 15 1990;65(11):729-35. [Medline].

  29. Sasaki Y, Furihata A, Suyama K, et al. Comparison between ventricular inhibited pacing and physiologic pacing in sick sinus syndrome. Am J Cardiol. Apr 1 1991;67(8):771-4. [Medline].

  30. Rosenqvist M, Brandt J, Schuller H. Long-term pacing in sinus node disease: effects of stimulation mode on cardiovascular morbidity and mortality. Am Heart J. Jul 1988;116(1 Pt 1):16-22. [Medline].

  31. Andersen HR, Nielsen JC, Thomsen PE, et al. Long-term follow-up of patients from a randomised trial of atrial versus ventricular pacing for sick-sinus syndrome. Lancet. Oct 25 1997;350(9086):1210-6. [Medline].

  32. Zanini R, Facchinetti A, Gallo G, et al. Survival rates after pacemaker implantation: a study of patients paced for sick sinus syndrome and atrioventricular block. Pacing Clin Electrophysiol. Jul 1989;12(7 Pt 1):1065-9. [Medline].

  33. Alpert MA, Curtis JJ, Sanfelippo JF, et al. Comparative survival after permanent ventricular and dual chamber pacing for patients with chronic high degree atrioventricular block with and without preexistent congestive heart failure. J Am Coll Cardiol. Apr 1986;7(4):925-32. [Medline].

  34. Bush DE, Finucane TE. Permanent cardiac pacemakers in the elderly. J Am Geriatr Soc. Mar 1994;42(3):326-34. [Medline].

  35. Schuller H, Brandt J. The pacemaker syndrome: old and new causes. Clin Cardiol. Apr 1991;14(4):336-40. [Medline].

  36. Torresani J, Ebagosti A, Allard-Latour G. Pacemaker syndrome with DDD pacing. Pacing Clin Electrophysiol. Nov 1984;7(6 Pt 2):1148-51. [Medline].

  37. Jais P, Barold S, Shah DC, et al. Pacemaker syndrome induced by the mode switching algorithm of a DDDR pacemaker. Pacing Clin Electrophysiol. Apr 1999;22(4 Pt 1):682-5. [Medline].

  38. Pascale P, Pruvot E, Graf D. Pacemaker syndrome during managed ventricular pacing mode: what is the mechanism?. J Cardiovasc Electrophysiol. May 2009;20(5):574-6. [Medline].

  39. Kastrup EK, Hebel SK, Olin BR. Drug Facts and Comparisons. 55th ed. 2001;1275-1288.

Further Reading

Keywords

pacemaker syndrome, subclinical pacemaker syndrome, pseudopacemaker syndrome, atrioventricular dyssynchrony, AV dyssynchrony, arrhythmia, ventricular pacing

Contributor Information and Disclosures

Author

Daniel M Beyerbach, MD, PhD,, Consulting Staff, Florida Electrophysiology Associates; Affiliate Clinical Assistant Professor of Biomedical Science, Florida Atlantic University, Regional Campus of University of Miami Miller School of Medicine
Daniel M Beyerbach, MD, PhD, is a member of the following medical societies: American College of Cardiology
Disclosure: Nothing to disclose.

Coauthor(s)

Christopher Cadman, MD, Director of Arrhythmia Service, Assistant Professor, Department of Internal Medicine, Division of Cardiology, University of New Mexico
Christopher Cadman, MD is a member of the following medical societies: American College of Cardiology and Phi Beta Kappa
Disclosure: Nothing to disclose.

Medical Editor

Hanumant Deshmukh, MD †, Former Chief of Cardiology, Veterans Affairs Medical Center; Former Associate Professor, Department of Medicine, Rosalind Franklin University of Medicine and Science
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: eMedicine Salary Employment

Managing Editor

Brian Olshansky, MD, Professor of Medicine, Department of Internal Medicine, University of Iowa College of Medicine
Brian Olshansky, MD is a member of the following medical societies: American Autonomic Society, American College of Cardiology, American College of Chest Physicians, American College of Physicians, American College of Sports Medicine, American Federation for Clinical Research, American Heart Association, Cardiac Electrophysiology Society, Heart Rhythm Society, and New York Academy of Sciences
Disclosure: Guidant/Boston Scientific Honoraria Speaking and teaching; Medtronic Honoraria Speaking and teaching; Guidant/Boston Scientific Consulting fee Consulting; Reliant Grant/research funds Other; Novartis Honoraria Speaking and teaching; Novartis Consulting fee Consulting

CME Editor

Amer Suleman, MD, Consultant in Electrophysiology and Cardiovascular Medicine, Department of Internal Medicine, Division of Cardiology, Medical City Dallas Hospital
Amer Suleman, MD is a member of the following medical societies: American College of Physicians, American Heart Association, American Institute of Stress, American Society of Hypertension, Federation of American Societies for Experimental Biology, Royal Society of Medicine, and Society of Cardiac Angiography and Interventions
Disclosure: Nothing to disclose.

Chief Editor

Michael E Zevitz, MD, Assistant Professor of Medicine, Finch University of the Health Sciences, The Chicago Medical School; Consulting Staff, Private Practice
Michael E Zevitz, MD is a member of the following medical societies: American College of Cardiology, American College of Physicians, American Medical Association, and Michigan State Medical Society
Disclosure: Nothing to disclose.

 
 
HONcode

We subscribe to the
HONcode principles of the
Health On the Net Foundation

All material on this website is protected by copyright, Copyright© 1994- by Medscape.
This website also contains material copyrighted by 3rd parties.

DISCLAIMER: The content of this Website is not influenced by sponsors. The site is designed primarily for use by qualified physicians and other medical professionals. The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for educational and informational purposes only. In no way should it be considered as offering medical advice. Please check with a physician if you suspect you are ill.