Holt-Oram Syndrome Follow-up
- Author: Craig T Basson, MD, PhD; Chief Editor: Park W Willis IV, MD more...
Further Inpatient Care
Admit patient for cardiovascular testing and surgical intervention.
Further Outpatient Care
- Follow up with patients with significant congenital heart disease at least annually.
- Periodic follow-up for cardiac conduction disease is warranted in all affected individuals.
Inpatient & Outpatient Medications
- No specific medications are indicated for this condition.
- Antibiotic prophylaxis and anticoagulation may be required depending on the severity of congenital heart disease.
Transfer
Transfer may be required for further diagnostic evaluation and surgical intervention.
Deterrence/Prevention
No known causative environmental factors are described; therefore, no particular deterrent is available.
Complications
- Congestive heart failure
- Arrhythmia
- Heart block
- Atrial fibrillation
- Infectious endocarditis
- Sudden death
Prognosis
Prognosis is generally good, but it depends on the severity of the cardiac malformations.
Patient Education
- Ensure that family members are aware that this is an autosomal dominant disorder and that the chance is 50% that offspring of an affected individual will also have the disorder.
- Explain that the severity of a lesion in a parent is not an indication of the potential severity in offspring.
- For excellent patient education resources, visit eMedicine's Heart Center. Also, see eMedicine's patient education articles Atrial Fibrillation and Ventricular Septal Defect.
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