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Eosinophilic Esophagitis 

  • Author: Nina Tatevian, MD, PhD; Chief Editor: Nirag C Jhala, MD, MBBS  more...
 
Updated: Nov 12, 2015
 

Definition

Primary eosinophilic esophagitis (EoE) is an emerging clinicopathologic entity that is characterized clinically by symptoms related to esophageal dysfunction and histologically by an eosinophil-rich inflammation that is limited to the esophagus.

In 2007, a multidisciplinary group proposed a consensus definition for the diagnosis of EoE based on the typical clinical presentation and pathologic findings in the absence of other known causes of tissue eosinophilia.[1] This group defined primary EoE as a clinicopathological disease characterized by the following:

  • Symptoms including, but not restricted to, food impaction and dysphagia in adults and feeding intolerance and gastroesophageal reflux disease (GERD) symptoms in children
  • Presence of 15 or more eosinophils per high power field (hpf) on esophageal biopsy
  • Exclusion of other disorders associated with similar clinical, histological, or endoscopic features, especially GERD (use of high-dose proton pump inhibitor [PPI] treatment or normal pH monitoring)

Subsequently, as the understanding of EoE evolved, a phenotypic heterogeneity in disease presentation was observed, such as PPI-responsive esophageal eosinophilia. Furthermore, the practical usefulness of the histological criteria was observed to be limited, as the presence of 15 or more eosinophils/hpf on esophageal biopsy samples could not be validated to successfully discriminate among various causes of esophageal eosinophilia, such as GERD, infections, Crohn disease, and hypersensitivity, among others. All of these factors led to a need to review the 2007 recommendations.

Therefore, in 2011, the multidisciplinary group proposed a new conceptual definition for EoE, according to which “Eosinophilic esophagitis represents a chronic immune/antigen mediated esophageal disease characterized clinically by symptoms related to esophageal dysfunction and histologically by eosinophil-predominant inflammation.”[2, 3]

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Epidemiology

The first case of eosinophilic esophagitis (EoE) was reported in 1977 in an adult patient;[4] however, it was not until the 1990s that it came to be recognized as a distinct clinical entity. In 1993, Attwood et al reported first case series of EoE in 12 adult patients and suggested that this is an entity distinct from GERD.[5] Subsequently, Kelly et al[6] reported a case series of 10 pediatric patients with eosinophilic infiltration of the esophagus whose gastrointestinal symptoms were unresponsive to standard antireflux treatment but improved with and amino acid–based formula diet. Since then, there has been an implosion of published literature on EoE.

Currently, EoE is believed to occur mainly in developed countries, affects both adults and children, and shows a male predominance.[7]

There is an increasing trend in newly diagnosed cases per year worldwide.[8] Whether this increase in incidence reflects a heightened awareness of EoE or a true increase is yet undetermined.[9]

In 2005, Straumann and Simon[10] reported an average incidence of 1.438 cases of EoE per 100,000 inhabitants over a 16-year observational period in Olten County, Switzerland. They noted a marked increase in newly diagnosed cases in later years. Since EoE is a chronic condition, this increased incidence reflected an increased prevalence. The authors of this study also suggested that the trend reflects a true increase in incidence and not just increased awareness.

Subsequently, Hruz et al,[11] in another demographic study from Olten county in Switzerland, reported an increased incidence in 6 years from 4.4-7.4 per 100,000 inhabitants per year and a prevalence of 43 patients with EoE per 100,000 inhabitants. This study in included both the pediatric and adult population. Similarly, in a study from western Australia,[12] an increasing trend in prevalence was observed in the pediatric population over a decade, from 0.05 to 0.89 per 10,000 children. Ronkainen et al[13] reported a prevalence of 1% EoE in the adult Swedish population.

In the United States, a pediatric population–based demographic study from Hamilton County in Ohio reported an annual incidence of EoE of 1 per 10,000 and a prevalence of 4.296 cases per 10,000 children.[14] Prasad et al,[8] in a retrospective study on epidemiologic trends of EoE in Olmsted county, Minnesota, reported an increasing incidence of EoE in three decades: 0.86 cases/100,000 population/year from 1976 to 1985 to 8.78 cases/100,000 population/year from 1996-2006. The prevalence of EoE, in this study, was reported to be 104.7 cases/100,000 population as of January 2007. Sorser et al[15] reported no increase in the incidence of EoE in their cohort of pediatric population over a period of 5 years from 2001-2006.

The current prevalence in developed countries is between 45 and 55 cases per 100,000 population.[16]

An increased prevalence of EoE has been observed in patients with celiac disease.[17, 18] An inverse relationship has been reported between the prevalence of Helicobacter pylori infection and esophageal eosinophilia.[19] Climate has been found to affect EoE prevalence. A recent study by Hurrell et al[20] reported that EoE is most prevalent in the cold and arid zones.

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Etiology

Eosinophilic esophagitis (EoE) has been hypothesized to be an atopic inflammatory disease. The etiopathogenesis is hypothesized to be an aberrant immune response to antigenic stimulation.[2] The atopic/allergenic nature of antigen is supported by studies that report a climatic and seasonal variation in presentation.[6, 15, 20, 21, 22] Most of these studies show an increase in new cases during spring or fall and some during summer. A high prevalence of EoE in cold and arid zones in the United states also supports the role of environmental factors in EoE.[20]

The esophagus is unique from the rest of gastrointestinal tract, as eosinophils are not a part of normal histology in esophagus. In other parts of the gastrointestinal tract, eosinophils are a normal component of mucosal infiltrate, even in the absence of disease process. In the late 1990s, murine studies demonstrated that eotaxin, an eosinophil chemoattractant chemokine, plays an important role in homing of eosinophils to the mucosal surface of the gastrointestinal tract.[23] The same group of researchers subsequently reported that interleukin-5 (IL-5), a T-helper 2 (Th2) cytokine, plays an important role in the induction of eosinophil trafficking to the esophagus.[24]

Another study demonstrated that delivery of another Th2 cytokine interleukin 13 (IL-13) to lungs induces EoE by inducing IL-5, eotaxin-1, through signal transducer and activation of a transcription (STAT)–6 dependent mechanism.[25] The results of this study established a link between lung and esophageal inflammation and suggested that direct exposure of esophageal mucosa to an allergen is not necessary for EoE to develop.

An in vitro study involving human esophageal mucosal tissue by Straumann et al[26] demonstrated that EoE induces a selective inflammatory response restricted to the esophagus and includes infiltration of esophageal mucosa by IL-5 expressing T-cells, B-cells, and eosinophils and immunoglobulin E (IgE) expressing mast cells. This landmark study provided scientific evidence for an atopic/allergenic basis of EoE.

In 2006, Blanchard et al[27] demonstrated eotaxin-3 as a critical effector molecule for EoE by gene expression profiling. Later, in an attempt to characterize the cytokine expression in EoE, they reported significantly increased esophageal expression of interleukin 4 (IL-4) and IL-5 mRNA in patients with active EoE. They also provided further evidence in their study that IL-13 and IL-5 associate with eosinophil and eotaxin-3 levels in patients with EoE, thereby indicating the key role of adaptive T(H)2 immunity in regulating eotaxin-3–driven esophageal eosinophilia in the absence of a consistent systemic change in cytokines.

Besides T-helper cells in the pathogenesis of EoE, there is also a role of mixed IgE– and non-IgE–mediated allergic response to food and environmental allergens.[28] This is based on the presence of positive skin prick test results and atopy patch test results to various antigens. In most children, EoE appears to be driven by food antigen exposure, which responds to the elimination of common dietary antigens and recurs upon reintroduction of those food antigens. These children have positive skin test result to a panel of allergens,[6, 29, 30] whereas, in adolescents and adults, aeroallergenic sensitization or atopic dermatitis/eczema is associated with about 60% of cases of EoE.[31]

Eosinophils play an integral role in remodeling of esophageal tissues, which is observed histologically as subepithelial fibrosis and manifests clinically as dysphagia in adults and vomiting in children. Eosinophils cause fibrosis through degranulation and secretion of their granule cationic proteins, particularly major basic protein (MBP) and eosinophil peroxidase (EPO) and elaboration of fibrogenic growth factors such as TGF-β, PDGF-BB, and IL-1β. The association of degranulating eosinophils and deposition of their granule cationic proteins in tissues with pathological fibrosis is a recurrent finding in a broad group of eosinophilic illnesses other than EoE, such as hypereosinophilic syndrome and asthma.[32, 33]

Noel et al have proposed that a genetic predisposition may exist.[14] Few reports of familial clustering of cases support this hypothesis.[34, 35]

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Location

Primary eosinophilic esophagitis (EoE) is a disease unique to the esophagus, with esophageal eosinophilia limited to the esophagus and involving both the proximal and distal esophagus.

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Clinical Features and Imaging

Primary eosinophilic esophagitis (EoE) affects all ethnic groups and both sexes. There is a slight male predominance, with a male-to-female ratio of 3:1.[2] It is a disease of both children and adults.

Generally, the clinical symptoms of EoE are nonspecific, and the patients are in good physical condition; therefore, in some cases, the diagnosis of EoE is made a few years after onset of symptoms.

The presenting symptoms vary depending on the age of onset.[36] Children tend to present with nausea and vomiting, weight loss, anemia, and failure to thrive. In neonates and infants, refusal of food is the most common presenting symptom.[14]

In a 2012 study, Sorser et al[15] reported vomiting as the most common presenting symptom in children and adolescents (61%), followed by dysphagia (39%), abdominal pain (34%), feeding disorders (14%), heartburn (14%), food impaction (7%), vague chest pain (5%), and diarrhea (5%). They further noted that vomiting and feeding disorders affected younger children, whereas heartburn and dysphagia occurred in older children.

In contrast, the characteristic symptom in adults includes dysphagia for solid foods, retrosternal pain, and food impaction. Some patients also present with GERD-like symptoms that are unresponsive to medical or surgical antireflux therapy. However, a subset of patients has been recognized to have a typical clinical presentation of EoE and have had GERD diagnostically excluded, yet show a clinicopathologic response to PPIs. This condition is currently referred to as PPI-responsive EoE.[2]

Patients in both adult and pediatric age groups often have a concomitant history of allergies such as food allergies, asthma, eczema, or chronic rhinitis. The laboratory workup shows mild peripheral eosinophilia in 5%-50% of children and adults.[16] Elevated total IgE levels are seen in about 70% of patients.[16]

Radiographic studies are not routinely performed for diagnosis of EoE owing to its low sensitivity.[2, 37]

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Gross Findings

Upper endoscopy for mucosal abnormalities is an integral part of the diagnostic workup in suspected eosinophilic esophagitis (EoE). The endoscopic mucosal changes may be seen through the entire length of the esophagus. The mucosal abnormalities are well described, but none of the features is pathognomonic for EoE and can be seen in other pathological conditions.[2]

The presence of a normal esophageal mucosa on endoscopy does not rule out EoE.[38]

A combination of mucosal abnormalities may be seen, and features vary depending on the stage of the disease. In EoE with active inflammation, the endoscopic findings include diminished vascular pattern, mucosal linear furrows, thick mucosa, and surface exudates. In chronic disease with tissue remodeling, mucosal abnormalities include crepe-paper mucosa (mucosal fragility), transient rings (feline folds), fixed rings (corrugated mucosa or trachealization), and strictures (diffuse narrowing of the esophagus).[16, 2, 39]

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Microscopic Findings

The normal histology of esophageal mucosa shows a nonkeratinizing stratified squamous epithelium, lamina propria, and muscularis mucosae. The basal cell layer is 1-3 cell layers thick and occupies about 10%-15% of the epithelium. The vascular papillae, which are extensions of lamina propria, extend less than two thirds of the distance from base to surface. Among inflammatory cells, intraepithelial lymphocytes are a normal component of esophageal squamous mucosa. However, eosinophils are not normally seen in esophageal squamous mucosa.

Normal esophagus Normal esophagus

Histopathologic evaluation plays an integral role in diagnosing eosinophilic esophagitis (EoE). A suspected case of EoE requires histologic confirmation on mucosal biopsy samples. On the same note, the presence of esophageal eosinophilia is not a pathognomonic histological feature of EoE. The presence of eosinophils in esophageal squamous mucosa is most commonly seen in GERD and EoE. Esophageal eosinophilia can also be seen various other pathological conditions, such as achalasia, connective-tissue diseases, vasculitis, drug reactions, and inflammatory bowel disease.[40]

In 2006, a multidisciplinary group at First International Gastrointestinal Eosinophil Research Symposium (FIGERS) proposed a histologic criterion of at least 15 eosinophils/hpf for a diagnosis of EoE based on extensive literature review; this criterion, among other recommendations, was published in 2007.[1, 3]

Increased eosinophils in squamous mucosa, >15/hpf Increased eosinophils in squamous mucosa, >15/hpf

Subsequently, the updated recommendations for diagnosis of EoE, published in 2011, stated no change in the threshold number of 15 eosinophils/hpf.[2] This was based on the observation that, since the 2007 consensus recommendations, no studies have identified a clear ‘‘lower limit of esophageal eosinophilia’’ or threshold number that would define EoE or have identified other histologic features or pattern of disease distribution that are pathognomonic of EoE.

Importantly, no change in the use of hpf as the unit of measurement for eosinophilia was made in the 2011 guidelines since no studies have yet determined a standardized size of an hpf. This technical issue is critical, because the size of an hpf can alter the reported number of eosinophils per hpf. The size of a hpf, measured in terms of area, varies from less than 0.1 mm2 to greater than 0.4 mm2, depending on the eyepiece used.[40]

Other pathologic features that support the diagnosis of EoE include degranulated eosinophils, eosinophilic microabscesses (defined as clusters of ≥4 eosinophils), presence of eosinophils in superficial layers of squamous mucosa with or without mucosal sloughing, patchy or diffuse distribution of eosinophils through the entire length of esophageal squamous mucosa, and lamina propria fibrosis.[2, 40, 41] Sloughed off squamous epithelial cells mixed with eosinophils are histologic correlates of white exudates observed on endoscopy.[42]

Superficial layering of eosinophils with desquamat Superficial layering of eosinophils with desquamation
Eosinophilic microabscesses Eosinophilic microabscesses

The updated consensus guidelines also recommend relaxation of the threshold criteria of eosinophils (>15 eosinophils/hpf) for diagnosis of EoE under certain circumstances, such as when there is a strong clinical evidence of EoE and the biopsy samples show above-mentioned supportive histological features.[2]

Multiple biopsies from the proximal and distal esophagus are recommended for optimal pathologic evaluation.[2] If biopsy samples from two or more sites show squamous mucosal eosinophil counts of more than 15 per hpf, then a diagnosis “compatible with EoE” may be rendered by the pathologist.[40]

Features of basal cell hyperplasia, dilated intercellular spaces, and elongation of vascular papillae are markers of esophagitis and are not very helpful in distinguishing reflux esophagitis from EoE. However, moderate to marked basal cell hyperplasia occupying more than 50% of mucosal thickness and papillary elongation to 75% of epithelial thickness has been associated with increased eosinophils[43, 44] and with eosinophil degranulation.[45] Esophageal subepithelial fibrosis has been observed to be related to the extent of esophageal eosinophil activation, as evidenced by eosinophil degranulation.[46]

Eosinophil degranulation Eosinophil degranulation
Architectural abnormalities (basal cell hyperplasi Architectural abnormalities (basal cell hyperplasia and elongation of vascular papillae)
Reflux esophagitis Reflux esophagitis

The presence of erosion, ulceration, and neutrophils are not features of EoE and favor an alternate cause such as reflux esophagitis, infections, or drug-related mucosal damage.

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Immunohistochemistry

Immunohistochemistry does not play a major role in the diagnosis of eosinophilic esophagitis (EoE), since the predominant inflammatory cell type is an eosinophil, which is easily recognized on hematoxylin and eosin–stained sections. Hence, the recommended diagnostic histological criterion of at least 15 eosinophils/hpf is based on hematoxylin and eosin–stained sections.

However, the use of MBP immunostaining (using monoclonal antibody against MBP) for detection of eosinophils has been shown to increase the yield of detection of eosinophils twofold, and the MBP expression in extracellular areas is thought to reflect foci of eosinophil degranulation.[45]

Immunohistochemical studies have shown an increase in CD3 and CD8 T lymphocytes in the esophageal mucosa of patients with EoE, together with an increase in the antigen presenting CD1a+ Langerhans cell population. Mast cells are also increased.[47, 48]

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Molecular/Genetics

The etiopathogenesis of eosinophilic esophagitis (EoE) is an evolving concept; to date, no biomarkers or molecular signatures have been identified that will aid in diagnosis of EoE.[2]

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Prognosis and Predictive Factors

Eosinophilic esophagitis (EoE) is a chronic, antigen-driven inflammatory disease with an allergenic nature of antigen. The disease has been seen to remit with treatment such as dietary exclusions of antigenic foods and/or topical steroids.[3, 49, 50]

Since EoE is a recently recognized entity, the natural history of EoE and predictive factors of complications are yet unknown.[2]

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Differentials:

The main differential diagnosis of eosinophilic esophagitis (EoE) is reflux esophagitis. Other differential diagnoses include primary eosinophilic gastroenteritis.

Reflux esophagitis

This is histological manifestation of GERD that causes esophageal mucosal damage by passive backflow of gastric contents into the distal esophagus. There is considerable histological overlap between reflux esophagitis and EoE. Typically, histological features of reflux esophagitis include mild to moderate basal cell hyperplasia, elongation of vascular papillae, dilated intercellular spaces, increased intraepithelial lymphocytosis, and the presence of intraepithelial eosinophils that number less than 5-7/hpf.

However, in some cases, distal esophageal biopsy samples show a spectrum of overlapping features of reflux esophagitis and EoE. These include moderate to marked basal cell hyperplasia (>50% of mucosal thickness), papillary elongation to 75% of mucosal thickness, dilated intercellular spaces, and the presence of peak intraepithelial eosinophilic counts ranging from 7-14/hpf. In such cases, histological evaluation of additional biopsy samples from the proximal esophagus and midesophagus may be helpful in reaching a more definitive diagnosis.[41, 40]

Primary eosinophilic gastroenteritis

Primary eosinophilic gastroenteritis also shows esophageal eosinophilia along with eosinophilic infiltration in other areas of the gastrointestinal tract . Additional biopsy samples from stomach, duodenum, and colon can help differentiate EoE from primary eosinophilic gastroenteritis.[41]

The main differential diagnosis is reflux esophagitis. Other differential diagnosis includes primary eosinophilic gastroenteritis.

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Contributor Information and Disclosures
Author

Nina Tatevian, MD, PhD FCAP, Associate Professor, Director, Pediatric/Perinatal Pathology Division, Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston; Adjunct Associate Professor, Department of Pathology, Baylor College of Medicine

Nina Tatevian, MD, PhD is a member of the following medical societies: American Society for Clinical Pathology, Association of Clinical Scientists, College of American Pathologists, Society for Pediatric Pathology

Disclosure: Nothing to disclose.

Coauthor(s)

Mamoun Younes, MD Professor of Pathology, Director of Gastrointestinal and Liver Pathology Service, University of Texas Medical School at Houston

Mamoun Younes, MD is a member of the following medical societies: American College of Gastroenterology, American Gastroenterological Association, College of American Pathologists, United States and Canadian Academy of Pathology, American Society of Clinical Oncology

Disclosure: Nothing to disclose.

Sadhna Dhingra, MBBS, MD Resident Physician, Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston

Sadhna Dhingra, MBBS, MD is a member of the following medical societies: College of American Pathologists, United States and Canadian Academy of Pathology, Indian Association of Pathologists and Microbiologists

Disclosure: Nothing to disclose.

Chief Editor

Nirag C Jhala, MD, MBBS Director of Anatomic Pathology, Director of Cytopathology, Temple University Hospital; Professor of Pathology and Laboratory Medicine, Temple University School of Medicine

Nirag C Jhala, MD, MBBS is a member of the following medical societies: American Society of Cytopathology, Biomedical Engineering Society, College of American Pathologists, International Academy of Cytology, United States and Canadian Academy of Pathology

Disclosure: Nothing to disclose.

Additional Contributors

Melissa P Upton, MD Associate Professor of Pathology, University of Washington School of Medicine; Associate Director, Anatomic Pathology Division, Director, Rodger C Haggitt Gastroenterologic and Hepatic Pathology Service, University of Washington Medical Center

Melissa P Upton, MD is a member of the following medical societies: American Society for Investigative Pathology, American Society for Clinical Pathology, College of American Pathologists, United States and Canadian Academy of Pathology, Transplantation Society, Hans Popper Hepatopathology Society, World Organization for Specialized Studies on Diseases of the Esophagus, Pacific Northwest Society of Pathologists

Disclosure: Nothing to disclose.

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Increased eosinophils in squamous mucosa, >15/hpf
Superficial layering of eosinophils with desquamation
Eosinophilic microabscesses
Eosinophil degranulation
Architectural abnormalities (basal cell hyperplasia and elongation of vascular papillae)
Normal esophagus
Reflux esophagitis
 
 
 
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