Third-Degree Atrioventricular Block Clinical Presentation
- Author: Adam S Budzikowski, MD, PhD; Chief Editor: Jeffrey N Rottman, MD more...
History
Third-degree atrioventricular (AV) block (ie, complete heart block) has a wide range of clinical presentations. Occasionally, patients are asymptomatic or have only minimal symptoms related to hypoperfusion. In these situations, symptoms include the following:
- Fatigue
- Dizziness
- Impaired exercise tolerance
- Chest pain
Patients with narrow complex escape rhythms (eg, those whose escape rhythm occurs above the His bundle) are more likely to have minimal symptoms.
More commonly, however, patients are profoundly symptomatic, especially if a wide-complex escape rhythm is present, indicating that the origin of the pacemaker is below the His bundle. In such cases, symptoms can include the following:
- Syncope
- Confusion
- Dyspnea
- Severe chest pain
- Sudden death
Because an acute myocardial infarction (MI) can cause complete heart block, patients who concurrently experience an MI can have associated symptoms from the MI, including chest pain, dyspnea, nausea or vomiting, and diaphoresis. Third-degree AV block may be an underlying condition in patients who present with sudden cardiac death.
Patients who have a history of cardiac disease may be on medications that affect the conduction system through the atrioventricular node (AVN), including the following:
- Beta-blockers
- Calcium channel blockers
- Digitalis cardioglycosides
The patient’s history of cardiac interventions should be carefully investigated; aortic valve surgery, septal alcohol ablation, proximal anterior descending artery stenting (complicated by compromised flow in the first septal perforator branch), and ablation of the slow or fast pathway of the AVN all may result in third-degree AV block.
Physical Examination
Initial triage of patients with complete heart block consists of determining symptoms, assessing vital signs, and looking for evidence of compromised peripheral perfusion. In particular, the physical examination findings of patients with third-degree AV block will be notable for bradycardia, which can be severe.
Careful examination of the neck veins can often show evidence of cannon ‘a’ waves. A variable intensity S1 may be heard. In addition, the pulse rate may be slow. If the slow rate or loss of atrial contraction prior to ventricular contraction has caused heart failure, then venous pressures will be elevated, including the jugular venous pressure.
Any new murmurs or gallops should be noted because strong associations exist between cardiomyopathies, mitral calcification, aortic calcification, or endocarditis and complete AV block. If heart failure is present as evidenced by rales, an S3 gallop, peripheral edema, or hepatomegaly, then a more compelling need for immediate pacing exists.
Because endocarditis, rheumatic fever, and Lyme disease cause heart block, pay attention to any signs of infection or skin rashes during the general examination. This is particularly true in endemic areas for Lyme disease.
Neurologic examination may provide clues to the etiology of AV block because neuromuscular disease, especially myotonic dystrophy and Duchenne muscular dystrophy, can cause AV block.
Signs of congestive heart failure as a result of decreased cardiac output may be present and may include the following:
- Tachypnea or respiratory distress
- Rales
- Jugular venous distention
Patients may have signs of hypoperfusion, including the following:
- Altered mental status
- Hypotension
- Lethargy
In patients with concomitant myocardial ischemia or MI, corresponding signs may be evident on examination:
- Signs of anxiety such as agitation or unease
- Diaphoresis
- Pale or pasty complexion
- Tachypnea
Regularized atrial fibrillation is the classic sign of complete heart block due to digitalis toxicity. This rhythm occurs because of the junctional escape rhythm.
Narula OS, Scherlag BJ, Javier RP, Hildner FJ, Samet P. Analysis of the A-V conduction defect in complete heart block utilizing His bundle electrograms. Circulation. Mar 1970;41(3):437-48. [Medline].
Rosen KM, Dhingra RC, Loeb HS, Rahimtoola SH. Chronic heart block in adults. Clinical and electrophysiological observations. Arch Intern Med. May 1973;131(5):663-72. [Medline].
Costedoat-Chalumeau N, Georgin-Lavialle S, Amoura Z, Piette JC. Anti-SSA/Ro and anti-SSB/La antibody-mediated congenital heart block. Lupus. 2005;14(9):660-4. [Medline].
Finsterer J, Stöllberger C, Steger C, Cozzarini W. Complete heart block associated with noncompaction, nail-patella syndrome, and mitochondrial myopathy. J Electrocardiol. Oct 2007;40:352-4. [Medline]. [Full Text].
Bestetti RB, Cury PM, Theodoropoulos TA, Villafanha D. Trypanosoma cruzi myocardial infection reactivation presenting as complete atrioventricular block in a Chagas' heart transplant recipient. Cardiovasc Pathol. Nov-Dec 2004;13(6):323-6. [Medline].
Ma TS, Collins TC, Habib G, Bredikis A, Carabello BA. Herpes zoster and its cardiovascular complications in the elderly--another look at a dormant virus. Cardiology. 2007;107:63-7. [Medline]. [Full Text].
Abuin G, Nieponice A, Barcelo A, Rojas-Granados A, Leu PH, Arteaga-Martinez M. Anatomical reasons for the discrepancies in atrioventricular block after inferior myocardial infarction with and without right ventricular involvement. Tex Heart Inst J. 2009;36(1):8-11. [Medline].
Nguyen HL, Lessard D, Spencer FA, Yarzebski J, Zevallos JC, Gore JM. Thirty-year trends (1975-2005) in the magnitude and hospital death rates associated with complete heart block in patients with acute myocardial infarction: a population-based perspective. Am Heart J. Aug 2008;156(2):227-33. [Medline].
Merin O, Ilan M, Oren A, Fink D, Deeb M, Bitran D. Permanent pacemaker implantation following cardiac surgery: indications and long-term follow-up. Pacing Clin Electrophysiol. Jan 2009;32(1):7-12. [Medline].
Kojic EM, Hardarson T, Sigfusson N, Sigvaldason H. The prevalence and prognosis of third-degree atrioventricular conduction block: the Reykjavik study. J Intern Med. Jul 1999;246(1):81-6. [Medline].
[Guideline] Epstein AE, Dimarco JP, Ellenbogen KA, Estes NA 3rd, Freedman RA, Gettes LS. ACC/AHA/HRS 2008 guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: executive summary. Heart Rhythm. Jun 2008;5(6):934-55. [Medline].
Guidelines for cardiopulmonary resuscitation and emergency cardiac care. Emergency Cardiac Care Committee and Subcommittees, American Heart Association. Part III. Adult advanced cardiac life support. JAMA. Oct 28 1992;268(16):2199-241. [Medline].
International Liaison Committee on Resuscitation. 2005 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations. Part 4: Advanced life support. Resuscitation. Nov-Dec 2005;67(2-3):213-47. [Medline].
Syverud S. Cardiac pacing. Emerg Med Clin North Am. May 1988;6(2):197-215. [Medline].

