Hepatocellular Adenoma Follow-up
- Author: Sandeep Mukherjee, MB, BCh, MPH, FRCPC; Chief Editor: Julian Katz, MD more...
Further Outpatient Care
- Yearly ultrasound imaging and an assessment of serum AFP levels is a consideration in all patients with hepatocellular adenomas.
Prognosis
- Complete resolution is atypical.
- The risk of malignant transformation remains even after the contraceptive or steroid use has been discontinued.
- The risk of malignant transformation exists and is as high as 8-13%.
Edmonson HA. Tumors of the liver and biliary tract. Fascicle 25. In: Atlas of Tumor Pathology. Washington, DC: Armed Forces Institute of Pathology; 1958.
Edmondson HA, Henderson B, Benton B. Liver-cell adenomas associated with use of oral contraceptives. N Engl J Med. Feb 26 1976;294(9):470-2. [Medline].
Baum JK, Bookstein JJ, Holtz F. Possible association between benign hepatomas and oral contraceptives. Lancet. Oct 27 1973;2(7835):926-9. [Medline].
Klatskin G. Hepatic tumors: possible relationship to use of oral contraceptives. Gastroenterology. Aug 1977;DA - 19770825(2):386-94. [Medline].
Rooks JB, Ory HW, Ishak KG. Epidemiology of hepatocellular adenoma. The role of oral contraceptive use. JAMA. Aug 17 1979;242(7):644-8. [Medline].
Cherqui D, Rahmouni A, Charlotte F, et al. Management of focal nodular hyperplasia and hepatocellular adenoma in young women: a series of 41 patients with clinical, radiological, and pathological correlations. Hepatology. Dec 1995;22(6):1674-81. [Medline].
Edmonson HA, Reynolds TB, Henderson B,et al. Regression of liver cell adenomas associated with oral contraceptives. Ann Int Med. 1977;86(2):180-182.
Labrune P, Trioche P, Duvaltier I, Chevalier P, Odievre M. Hepatocellular adenomas in glycogen storage disease type I and III: a series of 43 patients and review of the literature. J Pediatr Gastroenterol Nutr. Mar 1997;24(3):276-9. [Medline].
Volmar KE, Burchette JL, Creager AJ. Hepatic adenomatosis in glycogen storage disease type Ia: report of a case with unusual histology. Arch Pathol Lab Med. Oct 2003;127(10):e402-5. [Medline].
Grazioli L, Federle MP, Ichikawa T, et al. Liver adenomatosis: clinical, histopathologic, and imaging findings in 15 patients. Radiology. Aug 2000;216(2):395-402. [Medline].
Arsenault TM, Johnson CD, Gorman B, Burgart LJ. Hepatic adenomatosis. Mayo Clin Proc. May 1996;71(5):478-80. [Medline].
Masood S, West AB, Barwick KW. Expression of steroid hormone receptors in benign hepatic tumors. An immunocytochemical study. Arch Pathol Lab Med. Dec 1992;116(12):1355-9. [Medline].
Rebouissou S, Bioulac-Sage P, Zucman-Rossi J. Molecular pathogenesis of focal nodular hyperplasia and hepatocellular adenoma. J Hepatol. Jan 2008;48(1):163-70. [Medline].
Bioulac-Sage P, Blanc JF, Rebouissou S, Balabaud C, Zucman-Rossi J. Genotype phenotype classification of hepatocellular adenoma. World J Gastroenterol. May 21 2007;13(19):2649-54. [Medline].
Bioulac-Sage P, Laumonier H, Couchy G, et al. Hepatocellular adenoma management and phenotypic classification: the Bordeaux experience. Hepatology. Aug 2009;50(2):481-9. [Medline].
Reznik Y, Dao T, Coutant R, et al. Hepatocyte nuclear factor-1 alpha gene inactivation: cosegregation between liver adenomatosis and diabetes phenotypes in two maturity-onset diabetes of the young (MODY)3 families. J Clin Endocrinol Metab. Mar 2004;89(3):1476-80. [Medline].
Laumonier H, Bioulac-Sage P, Laurent C, et al. Hepatocellular adenomas: magnetic resonance imaging features as a function of molecular pathological classification. Hepatology. Sep 2008;48(3):808-18. [Medline].
Assy N, Nasser G, Djibre A, et al. Characteristics of common solid liver lesions and recommendations for diagnostic workup. World J Gastroenterol. Jul 14 2009;15(26):3217-27. [Medline].
Zucman-Rossi J, Jeannot E, Nhieu JT, et al. Genotype-phenotype correlation in hepatocellular adenoma: new classification and relationship with HCC. Hepatology. Mar 2006;43(3):515-24. [Medline].
Tretiakova MS, Hart J, Shabani-Rad MT, Zhang J, Gao ZH. Distinction of hepatocellular adenoma from hepatocellular carcinoma with and without cirrhosis using E-cadherin and matrix metalloproteinase immunohistochemistry. Mod Pathol. Aug 2009;22(8):1113-20. [Medline].
Wang HL, Anatelli F, Zhai QJ, et al. Glypican-3 as a useful diagnostic marker that distinguishes hepatocellular carcinoma from benign hepatocellular mass lesions. Arch Pathol Lab Med. Nov 2008;132(11):1723-8. [Medline].
Tatrai P, Somoracz A, Batmunkh E, et al. Agrin and CD34 immunohistochemistry for the discrimination of benign versus malignant hepatocellular lesions. Am J Surg Pathol. Jun 2009;33(6):874-85. [Medline].
Ahmad I, Iyer A, Marginean CE, et al. Diagnostic use of cytokeratins, CD34, and neuronal cell adhesion molecule staining in focal nodular hyperplasia and hepatic adenoma. Hum Pathol. May 2009;40(5):726-34. [Medline].
Ishak KG. Benign tumors and pseudotumors of the liver. Appl Pathol. 1988;6(2):82-104. [Medline].
Bisceglia M, Gatta A, Tomezzoli A, Donataccio M. Multiple spontaneous liver cell adenomas of different types (liver adenomatosis). Adv Anat Pathol. May 2009;16(3):172-9. [Medline].
Geller S, Petrovic L. Benign tumors and tumor-like conditions. Biopsy Interpretation of the Liver. 3rd ed. Philadelphia, Pa: Williams and Wilkins.; 2003:281-304.
Gyorffy EJ, Bredfeldt JE, Black WC. Transformation of hepatic cell adenoma to hepatocellular carcinoma due to oral contraceptive use. Ann Intern Med. Mar 15 1989;110(6):489-90. [Medline].
Terkivatan T, de Wilt JH, de Man RA, et al. Indications and long-term outcome of treatment for benign hepatic tumors: a critical appraisal. Arch Surg. Sep 2001;136(9):1033-8. [Medline].
Deneve JL, Pawlik TM, Cunningham S, et al. Liver cell adenoma: a multicenter analysis of risk factors for rupture and malignancy. Ann Surg Oncol. Mar 2009;16(3):640-8. [Medline].
Cho SW, Marsh JW, Steel J, et al. Surgical management of hepatocellular adenoma: take it or leave it?. Ann Surg Oncol. Oct 2008;15(10):2795-803. [Medline].
Selby R, Starzl TE, Ynis E, et al. Liver transplantation for type 1 and type glycogen storage disease. Eur J Pediatr. 1993;152:S71-76.
Santambrogio R, Marconi AM, Ceretti AP, et al. Liver transplantation for spontaneous intrapartum rupture of a hepatic adenoma. Obstet Gynecol. Feb 2009;113(2 pt 2):508-10. [Medline].
van Vledder MG, van Aalten SM, Terkivatan T, et al. Safety and efficacy of radiofrequency ablation for hepatocellular adenoma. J Vasc Interv Radiol. Jun 2011;22(6):787-93. [Medline].
Ryan IP, Havel RJ, Laros RK Jr. Three consecutive pregnancies in a patient with glycogen storage disease type IA (von Gierke's disease). Am J Obstet Gynecol. Jun 1994;170(6):1687-90; discussion 1690-1. [Medline].
Bioulac-Sage P, Laumonier H, Cubel G, Rossi JZ, Balabaud C. Hepatic resection for inflammatory hepatocellular adenomas: pathological identification of micronodules expressing inflammatory proteins. Liver Int. Jan 2010;30(1):149-54. [Medline].
Cai YR, Gong L, Teng XY, Zhang HT, Wang CF, Wei GL, et al. Clonality and allelotype analyses of focal nodular hyperplasia compared with hepatocellular adenoma and carcinoma. World J Gastroenterol. Oct 7 2009;15(37):4695-708. [Medline].
Curvo-Semedo L, Brito JB, Seco MF, Costa JF, Marques CB, Caseiro-Alves F. The Hypointense Liver Lesion on T2-Weighted MR Images and What It Means. Radiographics. Nov 18 2009;[Medline].
De Carlis L, Pirotta V, Rondinara GF. Hepatic adenoma and focal nodular hyperplasia: diagnosis and criteria for treatment. Liver Transpl Surg. Mar 1997;3(2):160-5. [Medline].
Jang HJ, Yu H, Kim TK. Contrast-enhanced ultrasound in the detection and characterization of liver tumors. Cancer Imaging. Nov 6 2009;9:96-103. [Medline].
Lee RG. Neoplasms and other masses: Benign hepatocellular tumors. In: Diagnostic Liver Pathology. St. Louis, Mo:. Mosby-Yearbook;1994:422-430.
Mergo PJ, Ros PR. Benign lesions of the liver. Radiol Clin North Am. Mar 1998;36(2):319-31. [Medline].
Mortele KJ, Ros PR. Benign liver neoplasms. Clin Liver Dis. Feb 2002;6(1):119-45.
Reddy KR, Schiff ER. Approach to a liver mass. Semin Liver Dis. Nov 1993;13(4):423-35. [Medline].
van der Sluis FJ, Bosch JL, Terkivatan T, et al. Hepatocellular adenoma: cost-effectiveness of different treatment strategies. Radiology. Sep 2009;252(3):737-46. [Medline].
Weimann A, Ringe B, Klempnauer J. Benign liver tumors: differential diagnosis and indications for surgery. World J Surg. Nov-Dec 1997;21(9):983-90; discussion 990-1. [Medline].

