Complications
- Esophageal rupture may lead to the development of septicemia, pneumomediastinum, mediastinitis, massive pleural effusion, empyema, pneumomediastinum, or subcutaneous emphysema.
- If the esophageal rupture extends directly into the pleura, hydropneumothorax is expected.
- In adults, this occurs more commonly on the left side of the pleura.
- In neonates, the esophageal rupture usually occurs on the right side.
- After the esophageal rupture, free air enters the mediastinum and also may spread to the adjacent structures and result in mediastinal abscess or superimposed secondary infection.
- Other complications include acute respiratory distress syndrome, pneumomediastinum, pneumothorax, and hydrothorax.
Prognosis
- Prognosis is directly contingent on early recognition and appropriate intervention.
- Early diagnosis of Boerhaave syndrome allows prompt surgical repair.
- Diagnosis and surgery within 24 hours carry a 75% survival rate. This drops to approximately 50% after a 24-hour delay and approximately 10% after 48 hours.
Korn O, Onate JC, Lopez R. Anatomy of the Boerhaave syndrome. Surgery. Feb 2007;141(2):222-8. [Medline].
de Schipper JP, Pull ter Gunne AF, Oostvogel HJ, van Laarhoven CJ. Spontaneous rupture of the oesophagus: Boerhaave's syndrome in 2008. Literature review and treatment algorithm. Dig Surg. 2009;26(1):1-6. [Medline].
Kish GF, Katske FA. A case of recurrent Boerhaave's syndrome. W V Med J. Feb 1980;76(2):27-30. [Medline].
Bladergroen MR, Lowe JE, Postlethwait RW. Diagnosis and recommended management of esophageal perforation and rupture. Ann Thorac Surg. Sep 1986;42(3):235-9. [Medline].
Restrepo CS, Lemos DF, Ocazionez D, Moncada R, Gimenez CR. Intramural hematoma of the esophagus: a pictorial essay. Emerg Radiol. Jan 2008;15(1):13-22. [Medline].
Ghassemi KF, Rodriguez HJ, Vesga L, et al. Endoscopic treatment of Boerhaave syndrome using a removable self-expandable plastic stent. J Clin Gastroenterol. Oct 2007;41(9):863-4. [Medline].
Zisis C, Guillin A, Heyries L, et al. Stent placement in the management of oesophageal leaks. Eur J Cardiothorac Surg. Mar 2008;33(3):451-6. [Medline].
Adam A, Watkinson AF, Dussek J. Boerhaave syndrome: to treat or not to treat by means of insertion of a metallic stent. J Vasc Interv Radiol. Sep-Oct 1995;6(5):741-3; discussion 744-6. [Medline].
Adams BD, Sebastian BM, Carter J. Honoring the Admiral: Boerhaave-van Wassenaer's syndrome. Dis Esophagus. 2006;19(3):146-51. [Medline].
Bjerke HS. Boerhaave's syndrome and barogenic injuries of the esophagus. Chest Surg Clin N Am. Nov 1994;4(4):819-25. [Medline].
Bonheim N, Alavi I. Boerhaave's syndrome: spontaneous rupture of the esophagus. Chic Med Sch Q. 1970;29(1):31-6. [Medline].
Chiu CL, Gambach RR. Spontaneous perforation of the esophagus (Boerhaave's syndrome). J Iowa Med Soc. Sep 1973;63(9):436-8. [Medline].
Clark W, Cook IJ. Spontaneous intramural haematoma of the oesophagus: radiologic recognition. Australas Radiol. Aug 1996;40(3):269-72. [Medline].
Craven GG, Whittaker MG. Boerhaave's syndrome as a complication of pre-existent gastrointestinal disease. Ir J Med Sci. Dec 1992;161(12):670-4. [Medline].
Crookes PF. RE: Hermann Boerhaave: the man behind the syndrome. Dis Esophagus. Oct 1997;10(4):303. [Medline].
Curtis DL, Burbige EJ, Milligan FD. Boerhaave's syndrome: role of esophagoscopy. Gastrointest Endosc. May 1976;22(4):208-9. [Medline].
Datta CK, Brannon JV. Spontaneous rupture of esophagus (Boerhaave syndrome): a review of literature and a case presentation. W V Med J. Jul 1979;75(7):180-2. [Medline].
Davies AP, Vaughan R. Expanding mesh stent in the emergency treatment of Boerhaave's syndrome. Ann Thorac Surg. May 1999;67(5):1482-3. [Medline].
Davis R. The Boerhaave syndrome associated with carcinoma of the oesophagus. S Afr Med J. Dec 1 1973;47(47):2269-72. [Medline].
Drury M, Anderson W, Heffner JE. Diagnostic value of pleural fluid cytology in occult Boerhaave's syndrome. Chest. Sep 1992;102(3):976-8. [Medline].
Duehring GL. Boerhaave syndrome. Radiol Technol. Sep-Oct 2000;72(1):51-5. [Medline].
Dumonceau JM, Deviere J, Cappello M, et al. Endoscopic treatment of Boerhaave's syndrome. Gastrointest Endosc. Oct 1996;44(4):477-9. [Medline].
Eubanks PJ, Hu E, Nguyen D, Procaccino F, et al. Case of Boerhaave's syndrome successfully treated with a self-expandable metallic stent. Gastrointest Endosc. Jun 1999;49(6):780-3. [Medline].
Hansen CP, Bertelsen S. Boerhaave's syndrome: spontaneous rupture of the oesophagus. Ann Chir Gynaecol. 1988;77(4):138-41. [Medline].
Henderson JA, Peloquin AJ. Boerhaave revisited: spontaneous esophageal perforation as a diagnostic masquerader. Am J Med. May 1989;86(5):559-67. [Medline].
Jagminas L, Silverman RA. Boerhaave's syndrome presenting with abdominal pain and right hydropneumothorax. Am J Emerg Med. Jan 1996;14(1):53-6. [Medline].
Janjua KJ. Boerhaave's syndrome. Postgrad Med J. May 1997;73(859):265-70. [Medline].
Jenkins IR, Raymond R. Boerhaave's syndrome complicated by a large bronchopleural fistula. Chest. Mar 1994;105(3):964-5. [Medline].
John BE, Zua MS. Boerhaave's syndrome--an elusive diagnosis. Tenn Med. Feb 1997;90(2):56-8. [Medline].
Kallis P, Belsham PA, Pepper JR. Spontaneous rupture of the oesophagus (Boerhaave's syndrome): conservative versus surgical management. J R Soc Med. Nov 1991;84(11):690-1. [Medline].
Klausner JM, Epstein L, Peer G, et al. Perforation of the esophagus (Boerhaave's syndrome) during hemodialysis. Nephron. 1985;40(3):372-3. [Medline].
Klin B, Berlatzky Y, Uretzky G. Boerhaave's syndrome: case report and review of the literature. Isr J Med Sci. Feb 1989;25(2):113-5. [Medline].
Kyriacou DN. A case of Boerhaave's syndrome presenting as diffuse left pulmonary infiltrate. Ann Emerg Med. Nov 1991;20(11):1239-42. [Medline].
Lawrence DR, Ohri SK, et al. Primary esophageal repair for Boerhaave's syndrome. Ann Thorac Surg. 1999;67(3):818-20. [Medline].
Levinsky L, Adler RH. Recurrent diagphragmatic herniation: following gastric onlay reinforcement of esophageal rupture (Boerhaave syndrome). N Y State J Med. Feb 1980;80(2):244-8. [Medline].
Levy F, Mysko WK, Kelen GD. Spontaneous esophageal perforation presenting with right-sided pleural effusion. J Emerg Med. May-Jun 1995;13(3):321-5. [Medline].
Lin WC, Chen JD, Tiu CM, et al. Boerhaave syndrome with atypical clinical presentations diagnosed by computed tomography. Zhonghua Yi Xue Za Zhi (Taipei). Jan 2002;65(1):45-8. [Medline].
Lujan HJ, Lin PH, Boghossian SP, et al. Recurrent spontaneous rupture of the esophagus: an unusual late complication of Boerhaave's syndrome. Surgery. Sep 1997;122(3):634-6. [Medline].
Marshall WB. Boerhaave syndrome: a case report. AANA J. Aug 2002;70(4):289-92. [Medline].
McCartney J, Dobrow J, Hendrix TR. Boerhaave syndrome. Johns Hopkins Med J. Jan 1979;144(1):28-33. [Medline].
Meyer GW, Castell DO. Evaluation and management of diseases of the esophagus. Am J Otolaryngol. Nov 1981;2(4):336-44. [Medline].
Michel L. Post-emetic laceration and rupture of the gastroesophageal junction. Acta Chir Belg. Jan-Feb 1982;82(1):13-24. [Medline].
Munemura T, Suzuki O, Ootake S, et al. A rare case of spontaneous esophageal rupture (Boerhaave's syndrome) associated with pulmonary rupture. Jpn J Thorac Cardiovasc Surg. Nov 1998;46(11):1074-7. [Medline].
Pezzulli FA, Aronson D, Goldberg N. Computed tomography of mediastinal hematoma secondary to unusual esophageal laceration: a Boerhaave variant. J Comput Assist Tomogr. Jan-Feb 1989;13(1):129-31. [Medline].
Phillips LG Jr, Cogbill CL, Makkar JC, et al. Barogenic rupture of the esophagus (Boerhaave's syndrome): successful treatment of a late case. Am Surg. Aug 1982;48(8):430-4. [Medline].
Rogers LF, Puig AW, Dooley BN, et al. Diagnostic considerations in mediastinal emphysema: a pathophysiologic-roentgenologic approach to Boerhaave's syndrome and spontaneous pneumomediastinum. Am J Roentgenol Radium Ther Nucl Med. Jul 1972;115(3):495-511. [Medline].
Rozycki GS. Image of the month. Esophageal perforation (Boerhaave syndrome). Arch Surg. Mar 2001;136(3):355-6. [Medline].
Sabanathan S, Eng J, Richardson J. Surgical management of intrathoracic oesophageal rupture. Br J Surg. Jun 1994;81(6):863-5. [Medline].
Sakamoto Y, Tanaka N, Furuya T, et al. Surgical management of late esophageal perforation. Thorac Cardiovasc Surg. Dec 1997;45(6):269-72. [Medline].
Salim AS. Jejunostomy feeding for the conservative management of spontaneous rupture of the oesophagus. Br J Clin Pract. Spring 1991;45(1):37-40. [Medline].
Salo JA, Seppala KM, Pitkaranta PP, et al. Spontaneous rupture and functional state of the esophagus. Surgery. Nov 1992;112(5):897-900. [Medline].
Scott HJ, Rosin RD. Thoracoscopic repair of a transmural rupture of the oesophagus (Boerhaave's syndrome). J R Soc Med. Jul 1995;88(7):414P-415P. [Medline].
Singh GS, Slovis CM. "Occult" Boerhaave's syndrome. J Emerg Med. Jan-Feb 1988;6(1):13-6. [Medline].
Smyth AR, Wastell C. Spontaneous rupture of the oesophagus (Boerhaave's syndrome): delayed diagnosis and successful conservative management. J R Soc Med. Aug 1989;82(8):498. [Medline].
Troum S, Lane CE, Dalton ML Jr. Surviving Boerhaave's syndrome without thoracotomy. Chest. Jul 1994;106(1):297-9. [Medline].
Van Nooten G, Azagra JS, Alle JL, et al. Spontaneous rupture of the esophagus after coronary artery bypass. Acta Chir Belg. Nov-Dec 1987;87(6):367-70. [Medline].
Weil RJ. Candidal mediastinitis after surgical repair of esophageal perforation. South Med J. Aug 1991;84(8):1052-3. [Medline].
White RK, Morris DM. Diagnosis and management of esophageal perforations. Am Surg. Feb 1992;58(2):112-9. [Medline].
Zawisza MJ, Geisler A. Spontaneous rupture of esophagus (Boerhaave's syndrome): case report and literature review. J Am Osteopath Assoc. Jun 1988;88(6):787-90. [Medline].

