eMedicine Specialties > Gastroenterology > Systemic Disease

Chylothorax

Author: Rosemary Kozar, MD, PhD, Assistant Professor, Department of Surgery, Division of General Surgery, University of Texas at Houston School of Medicine
Coauthor(s): Sasha D Adams, MD, Resident Physician, Department of Surgery, University of Texas at Houston School of Medicine; James Cipolla, MD, Attending Surgeon, St Luke's Hospital
Contributor Information and Disclosures

Updated: Aug 24, 2009

Introduction

Background

Chylothorax refers to the presence of lymphatic fluid in the pleural space secondary to leakage from the thoracic duct or one of its main tributaries. In 1875, H. Quinke described the first traumatic chylothorax. In 1948, R.S. Lampson performed the first thoracic duct ligation.

Anteroposterior upright chest radiograph shows a ...

Anteroposterior upright chest radiograph shows a massive left-sided pleural effusion with contralateral mediastinal shift. Image courtesy of Allen R. Thomas, MD.

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Anteroposterior upright chest radiograph shows a ...

Anteroposterior upright chest radiograph shows a massive left-sided pleural effusion with contralateral mediastinal shift. Image courtesy of Allen R. Thomas, MD.



A CT scan of the chest of a 3-year old child show...

A CT scan of the chest of a 3-year old child showing left side effusion and underlying parenchymal infiltrate and atelectasis. Image courtesy of Ibrahim Abdulhamid, MD.

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A CT scan of the chest of a 3-year old child show...

A CT scan of the chest of a 3-year old child showing left side effusion and underlying parenchymal infiltrate and atelectasis. Image courtesy of Ibrahim Abdulhamid, MD.

Pathophysiology

A tear or leak in the thoracic duct causes chylous fluid to collect in the pleural cavity, which can cause acute or chronic alterations in the pulmonary mechanics. In a normal adult, the thoracic duct transports up to 4 L of chyle per day, allowing a rapid and large accumulation of fluid in the chest.

Frequency

International

The prevalence after various cardiothoracic surgeries is 0.2-1%.

Mortality/Morbidity

Mortality and morbidity rates are approximately 10% in major clinical medical centers.

Sex

Chylothorax has no predilection for either sex.

Age

Chylothorax has no predilection for age.

Clinical

History

  • Usually, the patient remains asymptomatic until a large amount of chyle accumulates in the pleural space.
  • The average latent period between the insult and the onset of symptoms is 7-10 days. Symptoms include the following:
  • Rarely, patients may experience a rapid accumulation of fluid in the pleural space, causing a tension chylothorax. This is of particular concern following a pneumonectomy. These patients experience a rapid hemodynamic and respiratory compromise, similar to classic tension pneumothorax.

Physical

  • Findings on examination are nonspecific and include the following:
    • Decreased breath sounds
    • Shifting dullness
  • If the patient has an existing chest tube, excess drainage of 400-600 cc per 8-hour period is concerning for a chylous leak, particularly in postsurgical patients.

Causes

  • Nontraumatic
    • Malignant etiologies account for more than 50% of chylothorax diagnoses and are separated into lymphomatous and nonlymphomatous. Lymphoma is the most common cause, representing about 60% of all cases, with non-Hodgkin lymphoma more likely than Hodgkin lymphoma to cause a chylothorax. By comparison, nonlymphomatous causes are rare.
    • Nonmalignant etiologies are separated into idiopathic, congenital, and miscellaneous.
      • Clinicians must rule out all possible malignant causes before designating the chylothorax as idiopathic.
      • Congenital chylothorax is the leading cause of pleural effusion in neonates.1
      • Miscellaneous causes include cirrhosis, tuberculosis, sarcoidosis, amyloidosis, and filariasis.
  • Traumatic
    • Trauma is the second leading cause of chylothorax (25%).
    • Iatrogenic injury to the thoracic duct has been reported with most thoracic procedures. In particular, cardiothoracic surgery has been associated with 69-85% of cases of chylothorax in children.2 Milonakis et al examined their experience in managing chylothorax following congenital heart surgery. Of 1341 children who underwent correction of congenital heart disease, 18 (1.3%) developed postoperative chylothorax, which was managed with a therapeutic protocol that included complete drainage of chyle collection and controlled nutrition. Six children received adjunctive somatostatin. When lymph leakage persisted (range, 2.5-14.7 mL/kg/d for 8-42 days) despite conservative management, surgical intervention was implemented. Once chylothorax resolved, a 6-week diet of medium-chain triglycerides was given.No deaths occurred. Conservative therapy was effective in 15 patients (83.3%); 3 patients with persistent drainage required thoracotomy with pleurodesis to achieve resolution, 2 of whom had not had an effective response with previously attempted chemical pleurodesis with doxycycline (range of duration leakage, 5.1-7.4 mL/kg/d for 15-47 days).
    • Nonsurgical traumatic injury is a rare cause, usually secondary to penetrating trauma.
  • Pseudochylothorax
    • Chylothorax must be distinguished from pseudochylothorax, or cholesterol pleurisy, which results from accumulation of cholesterol crystals in a chronic existing effusion.
    • The most common cause of pseudochylothorax is chronic rheumatoid pleurisy, followed by tuberculosis and poorly treated empyema.

More on Chylothorax

Overview: Chylothorax
Differential Diagnoses & Workup: Chylothorax
Treatment & Medication: Chylothorax
Follow-up: Chylothorax
Multimedia: Chylothorax
References
Further Reading
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References

  1. Ergaz Z, Bar-Oz B, Yatsiv I, Arad I. Congenital chylothorax: clinical course and prognostic significance. Pediatr Pulmonol. Aug 2009;44(8):806-11. [Medline].

  2. Milonakis M, Chatzis AC, Giannopoulos NM, Contrafouris C, Bobos D, Kirvassilis GV, et al. Etiology and management of chylothorax following pediatric heart surgery. J Card Surg. Jul-Aug 2009;24(4):369-73. [Medline].

  3. Paul S, Altorki NK, Port JL, Stiles BM, Lee PC. Surgical management of chylothorax. Thorac Cardiovasc Surg. Jun 2009;57(4):226-8. [Medline].

  4. Panthongviriyakul C, Bines JE. Post-operative chylothorax in children: an evidence-based management algorithm. J Paediatr Child Health. Dec 2008;44(12):716-21. [Medline].

  5. Nath DS, Savla J, Khemani RG, Nussbaum DP, Greene CL, Wells WJ. Thoracic duct ligation for persistent chylothorax after pediatric cardiothoracic surgery. Ann Thorac Surg. Jul 2009;88(1):246-51; discussion 251-2. [Medline].

  6. Ammori JB, Pickens A, Chang AC. Tension chylothorax. Ann Thorac Surg. Aug 2006;82(2):729-30.

  7. Browse NL, Allen DR, Wilson NM. Management of chylothorax. Br J Surg. Dec 1997;84(12):1711-6. [Medline].

  8. Clarke SA, Lakhoo K, Sherwood W. Somatostatin for intractable postoperative chylothorax in a premature infant. Pediatr Surg Int. May 2005;21(5):390-1. [Medline].

  9. Hillerdal G. Chylothorax and pseudochylothorax. Eur Respir J. May 1997;10(5):1157-62. [Medline].

  10. Maskell NA, Butland RJ. BTS guidelines for the investigation of a unilateral pleural effusion in adults. Thorax. May 2003;58 Suppl 2:ii8-17.

  11. Merrigan BA, Winter DC, O'Sullivan GC. Chylothorax. Br J Surg. Jan 1997;84(1):15-20. [Medline].

  12. Mohseni-Bod H, Macrae D, Slavik Z. Somatostatin analog (octreotide) in management of neonatal postoperative chylothorax: is it safe?. Pediatr Crit Care Med. Jul 2004;5(4):356-7. [Medline].

  13. Ogi S, Fukumitsu N, Uchiyama M. A case of chylothorax diagnosed by lymphoscintigraphy using Tc-99m HSA-DTPA. Clin Nucl Med. Jun 2002;27(6):455-6. [Medline].

  14. Paes ML, Powell H. Chylothorax: an update. Br J Hosp Med. May 4-17 1994;51(9):482-90. [Medline].

  15. Postma GN, Keyser JS. Management of persistent chylothorax. Otolaryngol Head Neck Surg. Feb 1997;116(2):268-70. [Medline].

  16. Rice TW, Milstone AP. Chylothorax as a result of chronic lymphocytic leukemia: case report and review of the literature. South Med J. Mar 2004;97(3):291-4. [Medline].

  17. Sieczka EM, Harvey JC. Early thoracic duct ligation for postoperative chylothorax. J Surg Oncol. Jan 1996;61(1):56-60. [Medline].

  18. Valentine VG, Raffin TA. The management of chylothorax. Chest. Aug 1992;102(2):586-91. [Medline].

  19. Vallieres E, Shamji FM, Todd TR. Postpneumonectomy chylothorax. Ann Thorac Surg. Apr 1993;55(4):1006-8. [Medline].

  20. Wemyss-Holden SA, Launois B, Maddern GJ. Management of thoracic duct injuries after oesophagectomy. Br J Surg. Nov 2001;88(11):1442-8. [Medline].

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Further Reading

Related eMedicine Topics

Clinical Trials

National Guideline Clearinghouse

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Keywords

chylothorax, pleural effusion, pediatric chylothorax, neonatal chylothorax, thoracic duct leak, thoracic duct ligation, pleural chyle, pleural space, lymphoma, pleuroperitoneal shunt, pleurodesis, pleurectomy, chyle, postesophagectomy chylothorax, thoracentesis, lymphatic fluid, thoracic duct injury, loculated chylothorax

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Contributor Information and Disclosures

Author

Rosemary Kozar, MD, PhD, Assistant Professor, Department of Surgery, Division of General Surgery, University of Texas at Houston School of Medicine
Rosemary Kozar, MD, PhD is a member of the following medical societies: Society of University Surgeons
Disclosure: Nothing to disclose.

Coauthor(s)

Sasha D Adams, MD, Resident Physician, Department of Surgery, University of Texas at Houston School of Medicine
Sasha D Adams, MD is a member of the following medical societies: American College of Surgeons, American Medical Association, Association for Academic Surgery, and Association of Women Surgeons
Disclosure: Nothing to disclose.

James Cipolla, MD, Attending Surgeon, St Luke's Hospital
James Cipolla, MD is a member of the following medical societies: American College of Surgeons and Society of Critical Care Medicine
Disclosure: Nothing to disclose.

Medical Editor

Mounzer Al Al Samman, MD, Department of Internal Medicine, Division of Gastroenterology, Assistant Professor, Texas Tech University School of Medicine
Mounzer Al Al Samman, MD is a member of the following medical societies: American College of Gastroenterology, American College of Physicians, and American Gastroenterological Association
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: eMedicine Salary Employment

Managing Editor

BS Anand, MD, Professor, Department of Internal Medicine, Division of Gastroenterology, Baylor College of Medicine
BS Anand, MD is a member of the following medical societies: American Association for the Study of Liver Diseases, American College of Gastroenterology, American Gastroenterological Association, and American Society for Gastrointestinal Endoscopy
Disclosure: Nothing to disclose.

CME Editor

Alex J Mechaber, MD, FACP, Associate Dean for Undergraduate Medical Education, Associate Professor of Medicine, University of Miami Miller School of Medicine
Alex J Mechaber, MD, FACP is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians-American Society of Internal Medicine, and Society of General Internal Medicine
Disclosure: Nothing to disclose.

Chief Editor

Julian Katz, MD, Clinical Professor of Medicine, Drexel University College of Medicine; Consulting Staff, Department of Medicine, Section of Gastroenterology and Hepatology, Hospital of the Medical College of Pennsylvania
Julian Katz, MD is a member of the following medical societies: American College of Gastroenterology, American College of Physicians, American Gastroenterological Association, American Geriatrics Society, American Medical Association, American Society for Gastrointestinal Endoscopy, American Society of Law Medicine and Ethics, American Trauma Society, Association of American Medical Colleges, and Physicians for Social Responsibility
Disclosure: Nothing to disclose.

 
 
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