eMedicine Specialties > Gastroenterology > Liver
Hepatic Cystadenomas: Follow-up
Updated: Nov 11, 2009
Follow-up
Further Outpatient Care
- No further outpatient care is indicated routinely after complete surgical resection. However, because local recurrence of a cystadenoma with progression to cellular atypia and, ultimately, carcinoma has been described, regular postoperative follow-up is indicated. Follow-up is conducted best by performing abdominal US or CT scan at 6-month intervals for the first postoperative year and then annually.
Deterrence/Prevention
- No preventive measures are required.
Complications
- Bleeding
- Rupture
- Obstructive jaundice
- Malignant transformation
- Infection
- Gastric outlet obstruction
- Ascites
- Inferior vena cava obstruction
Prognosis
- The prognosis of hepatic cystadenomas is extremely good if patients undergo a complete surgical resection. Improper treatment, such as marsupialization, internal Roux-en-Y drainage, or percutaneous drainage and alcoholization, is associated with almost certain recurrence. In particular, aspiration or partial excision of cystadenomas is associated with a recurrence rate of higher than 90%.
Miscellaneous
Medicolegal Pitfalls
- Improper treatment, such as marsupialization, internal Roux-en-Y drainage, or percutaneous drainage and alcoholization, is associated with almost certain recurrence. In particular, aspiration or partial excision of cystadenomas is associated with a recurrence rate of higher than 90%.
The authors and editors of eMedicine gratefully acknowledge the contributions of the previous author and coauthors, Andrea Duchini, MD, John Goss, MD, Murat Kilic, MD, Philip Seu, MD, and Paul J Pockros, MD, to the development and writing of this article.
More on Hepatic Cystadenomas |
| Overview: Hepatic Cystadenomas |
| Differential Diagnoses & Workup: Hepatic Cystadenomas |
| Treatment & Medication: Hepatic Cystadenomas |
Follow-up: Hepatic Cystadenomas |
| References |
| Further Reading |
| « Previous Page |
References
Fukunaga N, Ishikawa M, Ishikura H, Ichimori T, Kimura S, Sakata A, et al. Hepatobiliary cystadenoma exhibiting morphologic changes from simple hepatic cyst shown by 11-year follow up imagings. World J Surg Oncol. Dec 11 2008;6:129. [Medline].
Choi HK, Lee JK, Lee KH, Lee KT, Rhee JC, Kim KH, et al. Differential Diagnosis for Intrahepatic Biliary Cystadenoma and Hepatic Simple Cyst: Significance of Cystic Fluid Analysis and Radiologic Findings. J Clin Gastroenterol. Sep 18 2009;[Medline].
Zhang YL, Yuan L, Shen F, Wang Y. Hemorrhagic hepatic cysts mimicking biliary cystadenoma. World J Gastroenterol. Sep 28 2009;15(36):4601-3. [Medline].
Gamblin TC, Holloway SE, Heckman JT, Geller DA. Laparoscopic resection of benign hepatic cysts: a new standard. J Am Coll Surg. Nov 2008;207(5):731-6. [Medline].
Abdul-Al HM, Makhlouf HR, Goodman ZD. Expression of estrogen and progesterone receptors and inhibin-alpha in hepatobiliary cystadenoma: an immunohistochemical study. Virchows Arch. Jun 2007;450(6):691-7. [Medline].
Baudin G, Novellas S, Buratti MS, Saint-Paul MC, Chevallier P, Gugenheim J, et al. Atypical MRI features of a biliary cystadenoma revealed by jaundice. Clin Imaging. Nov-Dec 2006;30(6):413-5. [Medline].
Catinis GE, Frey DJ, Skinner JW, Balart LA. Hepatic cystadenoma: an unusual presentation. Am J Gastroenterol. May 1998;93(5):827-9. [Medline].
D'Errico A, Deleonardi G, Fiorentino M, Scoazec JY, Grigioni WF. Diagnostic implications of albumin messenger RNA detection and cytokeratin pattern in benign hepatic lesions and biliary cystadenocarcinoma. Diagn Mol Pathol. Dec 1998;7(6):289-94. [Medline].
Dardik H, Glotzer P, Silver C. Congenital hepatic cyst causing jaundice: report of a case and analogies with respiratory malformation. Ann Surg. Apr 1964;159:585-92. [Medline].
Franko J, Nussbaum ML, Morris JB. Choledochal cyst cholangiocarcinoma arising from adenoma: case report and a review of the literature. Curr Surg. Jul-Aug 2006;63(4):281-4. [Medline].
Grayson W, Teare J, Myburgh JA, Paterson AC. Immunohistochemical demonstration of progesterone receptor in hepatobiliary cystadenoma with mesenchymal stroma. Histopathology. Nov 1996;29(5):461-3. [Medline].
Horsmans Y, Laka A, Gigot JF, Geubel AP. Serum and cystic fluid CA 19-9 determinations as a diagnostic help in liver cysts of uncertain nature. Liver. Aug 1996;16(4):255-7. [Medline].
Ishak KG, Willis GW, Cummins SD, Bullock AA. Biliary cystadenoma and cystadenocarcinoma: report of 14 cases and review of the literature. Cancer. Jan 1977;39(1):322-38. [Medline].
Jenkins RL, Johnson LB, Lewis WD. Surgical approach to benign liver tumors. Semin Liver Dis. May 1994;14(2):178-89. [Medline].
Kanamori H, Kawahara H, Oh S, Mine T, Osawa H, Murakami T, et al. A case of biliary cystadenocarcinoma with recurrent jaundice. Diagnostic evaluation of computed tomography. Cancer. Jun 1 1985;55(11):2722-4. [Medline].
Karahan OI, Kahriman G, Soyuer I, Ok E. Hepatic von Meyenburg complex simulating biliary cystadenocarcinoma. Clin Imaging. Jan-Feb 2007;31(1):50-3. [Medline].
Koffron A, Rao S, Ferrario M, Abecassis M. Intrahepatic biliary cystadenoma: role of cyst fluid analysis and surgical management in the laparoscopic era. Surgery. Oct 2004;136(4):926-36. [Medline].
Mills GC, Alperin JB, Trimmer KB. Studies on variant glucose-6-phosphate dehydrogenases: G6PD Fort Worth. Biochem Med. Jul 1975;13(3):264-75. [Medline].
Ramacciato G, Nigri GR, D'Angelo F, Aurello P, Bellagamba R, Colarossi C, et al. Emergency laparotomy for misdiagnosed biliary cystadenoma originating from caudate lobe. World J Surg Oncol. 2006;4:76. [Medline].
Sanchez H, Gagner M, Rossi RL, Jenkins RL, Lewis WD, Munson JL, et al. Surgical management of nonparasitic cystic liver disease. Am J Surg. Jan 1991;161(1):113-8; discussion 118-9. [Medline].
Shimada M, Takenaka K, Gion T, Fujiwara Y, Taguchi K, Kajiyama K, et al. Treatment strategy for patients with cystic lesions mimicking a liver tumor: a recent 10-year surgical experience in Japan. Arch Surg. Jun 1998;133(6):643-6. [Medline].
Teoh AY, Ng SS, Lee KF, Lai PB. Biliary cystadenoma and other complicated cystic lesions of the liver: diagnostic and therapeutic challenges. World J Surg. Aug 2006;30(8):1560-6. [Medline].
Terada T, Kitamura Y, Ohta T. Endocrine cells in hepatobiliary cystadenomas and cystadenocarcinomas. Virchows Arch. Jan 1997;430(1):37-40. [Medline].
Wheeler DA, Edmondson HA. Cystadenoma with mesenchymal stroma (CMS) in the liver and bile ducts. A clinicopathologic study of 17 cases, 4 with malignant change. Cancer. Sep 15 1985;56(6):1434-45. [Medline].
Woods GL. Biliary cystadenocarcinoma: Case report of hepatic malignancy originating in benign cystadenoma. Cancer. Jun 15 1981;47(12):2936-40. [Medline].
Further Reading
Clinical guideline
ACR Appropriateness Criteria® liver lesion characterization.
American College of Radiology - Medical Specialty Society. 1998 (revised 2006). 7 pages. NGC:005115
Clinical trial
Evaluation of Intra-operative Ultrasound Contrast Enhancement in the Evaluation of Liver Tumors
Related eMedicine topics
Biliary Cystadenoma/Cystadenocarcinoma
Cholangitis
Hepatic Cysts
Liver, Metastases
Bile Duct Tumors
Keywords
hepatic cystadenoma, liver cyst, liver cysts, hepatic cyst, hepatic cysts, cyst on liver, cysts on liver, hepatic lesion, hepatic lesions, liver cyst symptoms, biliary cystadenoma, multilocular cystic tumor, cystic tumor, liver tumor, liver adenoma, liver cystadenoma, liver lesion, benign tumor, hepatic tumor
Follow-up: Hepatic Cystadenomas