eMedicine Specialties > Gastroenterology > Stomach
Dumping Syndrome: Differential Diagnoses & Workup
Updated: Jun 10, 2008
- Overview
- Differential Diagnoses & Workup
- Treatment & Medication
- Multimedia
Workup
Laboratory Studies
- Signs and symptoms can be elicited with the glucose challenge test.
Other Tests
- A positive result from a hydrogen breath test after ingestion of glucose is also 100% sensitive.
- A gastric emptying study may be helpful to document rapid gastric emptying.
Procedures
- An endoscopy or a barium study can be helpful in discerning the anatomy.
More on Dumping Syndrome |
| Overview: Dumping Syndrome |
Differential Diagnoses & Workup: Dumping Syndrome |
| Treatment & Medication: Dumping Syndrome |
| Multimedia: Dumping Syndrome |
| References |
| « Previous Page | Next Page » |
References
Azpiroz F, Malagelada JR. Gastric tone measured by an electronic barostat in health and postsurgical gastroparesis. Gastroenterology. Apr 1987;92(4):934-43. [Medline].
Hertz AF. IV. The Cause and Treatment of Certain Unfavorable After-effects of Gastro-enterostomy. Ann Surg. Oct 1913;58(4):466-72. [Medline].
Mix CL. Dumping following gastrojejunostomy. Surg Clin North Am. 1922;2:617.
Kalser MH, Cohen R. Correlation of jejunal transfer of water and electrolytes with blood volume in postgastrectomy patients: response to hypertonic glucose meal. Ann Surg. Nov 1966;164(5):821-9. [Medline].
Hinshaw DB, Joergerson EJ, Davis HA. Peripheral blood flow and blood volume studies in the dumping syndrome. Arch Surg. 1957;74:686.
Holdsworth CD, Turner D, McIntyre N. Pathophysiology of post-gastrectomy hypoglycaemia. Br Med J. Nov 1 1969;4(5678):257-9. [Medline].
Geer RJ, Richards WO, O'Dorisio TM, Woltering EO, Williams S, Rice D, et al. Efficacy of octreotide acetate in treatment of severe postgastrectomy dumping syndrome. Ann Surg. Dec 1990;212(6):678-87. [Medline].
Porter HW, Claman ZB. A preliminary report on the advantage of small stoma in partial gastrectomy for ulcer. Ann Surg. 1954;129:417.
Woodward ER, Desser PL, Gasster M. Surgical treatment of postgastrectomy dumping syndrome. West J Surg. 1955;63:567.
Koruth NM, Krukowski ZH, Matheson NA. Pyloric reconstruction. Br J Surg. Oct 1985;72(10):808-10. [Medline].
Cheadle WG, Baker PR, Cuschieri A. Pyloric reconstruction for severe vasomotor dumping after vagotomy and pyloroplasty. Ann Surg. Nov 1985;202(5):568-72. [Medline].
Henley FA. Experiences with jejunal interposition for correction of postgastrectomy syndromes. In: Harkins HN, Nyhus LM, eds. Surgery of the stomach and duodenum. Boston, Mass: Little Brown and Company; 1969:777.
Sawyers JL, Herrington JL Jr. Superiority of antiperistaltic jejunal segments in management of severe dumping syndrome. Ann Surg. Sep 1973;178(3):311-21. [Medline].
Vogel SB, Hocking MP, Woodward ER. Clinical and radionuclide evaluation of Roux-Y diversion for postgastrectomy dumping. Am J Surg. Jan 1988;155(1):57-62. [Medline].
Abbott WE, Krieger H, Levey S. Technical surgical factors which enhance or minimize postgastrectomy abnormalities. Ann Surg. 1958;148:567.
Andreasen JJ, Orskov C, Holst JJ. Secretion of glucagon-like peptide-1 and reactive hypoglycemia after partial gastrectomy. Digestion. 1994;55(4):221-8. [Medline].
Blackburn AM, Christofides ND, Ghatei MA, Sarson DL, Ebeid FH, Ralphs DN, et al. Elevation of plasma neurotensin in the dumping syndrome. Clin Sci (Lond). Oct 1980;59(4):237-43. [Medline].
Bloom SR, Royston CM, Thomson JP. Enteroglucagon release in the dumping syndrome. Lancet. Oct 14 1972;2(7781):789-91. [Medline].
Burkhalter E. Incidence of gastrectomy in United States army hospitals worldwide from 1975 to 1985. Am J Gastroenterol. Nov 1988;83(11):1231-4. [Medline].
Carvajal SH, Mulvihill SJ. Postgastrectomy syndromes: dumping and diarrhea. Gastroenterol Clin North Am. Jun 1994;23(2):261-79. [Medline].
Cranley B, Kelly KA, Go VL, McNichols LA. Enhancing the anti-dumping effect of Roux gastrojejunostomy with intestinal pacing. Ann Surg. Oct 1983;198(4):516-24. [Medline].
Didden P, Penning C, Masclee AA. Octreotide therapy in dumping syndrome: Analysis of long-term results. Aliment Pharmacol Ther. Nov 1 2006;24(9):1367-75. [Medline].
Duthie HL, Irvine WT, Kerr JW. Cardiovascular changes in post-gastrectomy syndrome. Br J Surg. 1959;46:350.
Eisenberg MM, Woodward ER, Carson TJ, Dragstedt LR. Vagotomy and drainage procedure for duodenal ulcer: the results of ten years' experience. Ann Surg. Sep 1969;170(3):317-28. [Medline].
Gray JL, Debas HT, Mulvihill SJ. Control of dumping symptoms by somatostatin analogue in patients after gastric surgery. Arch Surg. Oct 1991;126(10):1231-5; discussion 1235-6. [Medline].
Gustavsson S, Kelly KA, Melton LJ 3rd, Zinsmeister AR. Trends in peptic ulcer surgery. A population-based study in Rochester, Minnesota, 1956-1985. Gastroenterology. Mar 1988;94(3):688-94. [Medline].
Hasler WL, Soudah HC, Owyang C. Mechanisms by which octreotide ameliorates symptoms in the dumping syndrome. J Pharmacol Exp Ther. Jun 1996;277(3):1359-65. [Medline].
Hockings MP, Vogel SB. Woodward's postgastrectomy syndromes. Philadelphia, Pa: WB Saunders; 1991:195.
Hoffmann J, Jensen HE, Christiansen J, Olesen A, Loud FB, Hauch O. Prospective controlled vagotomy trial for duodenal ulcer. Results after 11-15 years. Ann Surg. Jan 1989;209(1):40-5. [Medline].
Holst JJ. Glucagonlike peptide 1: a newly discovered gastrointestinal hormone. Gastroenterology. Dec 1994;107(6):1848-55. [Medline].
Hopman WP, Wolberink RG, Lamers CB, Van Tongeren JH. Treatment of the dumping syndrome with the somatostatin analogue SMS 201-995. Ann Surg. Feb 1988;207(2):155-9. [Medline].
Johnson LP, Jesseph JE. Evidence of a humoral etiology of the dumping syndrome. Surg Forum. 1961;12:316.
Johnston D, Blackett RL. A new look at selective vagotomies. Am J Surg. Nov 1988;156(5):416-27. [Medline].
Karamanolis G, Tack J. Nutrition and motility disorders. Best Pract Res Clin Gastroenterol. 2006;20(3):485-505. [Medline].
Khoshoo V, Reifen RM, Gold BD, Sherman PM, Pencharz PB. Nutritional manipulation in the management of dumping syndrome. Arch Dis Child. Dec 1991;66(12):1447-8. [Medline].
Krieger H, Levey S. Technical surgical factors which enhance or minimize postgastrectomy abnormalities. Ann Surg. 1958;148:567.
Lamers CB, Bijlstra AM, Harris AG. Octreotide, a long-acting somatostatin analog, in the management of postoperative dumping syndrome. An update. Dig Dis Sci. Feb 1993;38(2):359-64. [Medline].
Lawaetz O, Blackburn AM, Bloom SR, Aritas Y, Ralphs DN. Gut hormone profile and gastric emptying in the dumping syndrome. A hypothesis concerning the pathogenesis. Scand J Gastroenterol. Jan 1983;18(1):73-80. [Medline].
Layer P, Holst JJ, Grandt D, Goebell H. Ileal release of glucagon-like peptide-1 (GLP-1). Association with inhibition of gastric acid secretion in humans. Dig Dis Sci. May 1995;40(5):1074-82. [Medline].
LeQuesne LP, Hobsley M, Hand BH. The dumping syndrome I. Factors responsible for the symptoms. Br Med J. 1960;1:141.
Lygidakis NJ. A new method for the surgical treatment of the dumping syndrome. Ann R Coll Surg Engl. Nov 1981;63(6):411-4. [Medline].
Machella TE. The mechanism of postgastrectomy dumping. Surg. 1949;130:145.
Mackie CR, Jenkins SA, Hartley MN. Treatment of severe postvagotomy/postgastrectomy symptoms with the somatostatin analogue octreotide. Br J Surg. Nov 1991;78(11):1338-43. [Medline].
Meyer JH, Thompson JB, Cohen MB. Motility of the stomach and the gastroduodenal junction. In: Johnson LR, ed. The Physiology of the Gastrointestinal Tract. 2nd ed. New York, NY: Raven Press; 1987:625-9.
Meyer JH, Thomson JB, Cohen MB, Shadchehr A, Mandiola SA. Sieving of solid food by the canine stomach and sieving after gastric surgery. Gastroenterology. Apr 1979;76(4):804-13. [Medline].
Miholic J, Reilmann L, Meyer HJ, Körber H, Kotzerke J, Hecker H. Extracellular space, blood volume, and the early dumping syndrome after total gastrectomy. Gastroenterology. Oct 1990;99(4):923-9. [Medline].
Norryd C, Dencker H, Lunderquist A, Olin T, Tylén U. Superior mesenteric blood flow during experimentally induced dumping in man. Acta Chir Scand. 1975;141(3):187-96. [Medline].
Overton RC, Jordon GLJ, DeBakey ME. The postgastrectomy syndrome: studies of pathogenesis. Ann Surg. 1957;145:471.
Paimela H, Tuompo PK, Perakyl T, Saario I, Hockerstedt K, Kivilaakso E. Peptic ulcer surgery during the H2-receptor antagonist era: a population-based epidemiological study of ulcer surgery in Helsinki from 1972 to 1987. Br J Surg. Jan 1991;78(1):28-31. [Medline].
Pedersen JH, Beck H, Shokouh-Amiri M, Fischer A. Effect of neurotensin in the dumping syndrome. Scand J Gastroenterol. May 1986;21(4):478-82. [Medline].
Penning C, Vecht J, Masclee AA. Efficacy of depot long-acting release octreotide therapy in severe dumping syndrome. Aliment Pharmacol Ther. Nov 15 2005;22(10):963-9. [Medline].
Perman E. The so-called dumping syndrome after gastrectomy. Acta Med Scan. 1947;128 (suppl 196):361.
Ralphs DN, Thomson JP, Haynes S, Lawson-Smith C, Hobsley M, Le Quesne LP. The relationship between the rate of gastric emptying and the dumping syndrome. Br J Surg. Sep 1978;65(9):637-41. [Medline].
Roberts KE, Randall HT, Farr HW. Cardiovascular and blood volume alterations resulting from intrajejunal administration of hypertonic solutions to gastrectomized patients: The relationship of these changes to the dumping syndrome. Ann Surg. 1954;140:631.
Sagor GR, Bryant MG, Ghatei MA, Kirk RM, Bloom SR. Release of vasoactive intestinal peptide in the dumping syndrome. Br Med J (Clin Res Ed). Feb 14 1981;282(6263):507-10. [Medline].
Sawyers JL. Management of postgastrectomy syndromes. Am J Surg. Jan 1990;159(1):8-14. [Medline].
Sigstad H. A clinical diagnostic index in the diagnosis of the dumping syndrome. Changes in plasma volume and blood sugar after a test meal. Acta Med Scand. Dec 1970;188(6):479-86. [Medline].
Snook JA, Wells AD, Prytherch DR, Evans DH, Bloom SR, Colin-Jones DG. Studies on the pathogenesis of the early dumping syndrome induced by intraduodenal instillation of hypertonic glucose. Gut. Dec 1989;30(12):1716-20. [Medline].
Tack J. Gastric motor disorders. Best Pract Res Clin Gastroenterol. 2007;21(4):633-44. [Medline].
Tulassay Z, Tulassay T, Gupta R, Cierny G. Long acting somatostatin analogue in dumping syndrome. Br J Surg. Dec 1989;76(12):1294-5. [Medline].
Ukleja A. Dumping syndrome: pathophysiology and treatment. Nutr Clin Pract. Oct 2005;20(5):517-25. [Medline].
van der Kleij FG, Vecht J, Lamers CB, Masclee AA. Diagnostic value of dumping provocation in patients after gastric surgery. Scand J Gastroenterol. Dec 1996;31(12):1162-6. [Medline].
Vetch J, Lambers RJ. Octreotide influences small intestinal motility and transit time in fasting and fed states. Gastro. 1994;106:A583.
Visick AH. A study of the failures after gastrectomy. Ann R Coll Surg Engl. 1948;3:266.
Wong PY, Talamo RC, Babior BM, Raymond GG, Colman RW. Kallikrein-kinin system in postgastrectomy dumping syndrome. Ann Intern Med. May 1974;80(5):577-81. [Medline].
Zeitlin IJ, Smith AN. 5-hydroxyindoles and kinins in the carcinoid and dumping syndromes. Lancet. Nov 5 1966;2(7471):986-91. [Medline].
Further Reading
Keywords
postgastrectomy syndromes, small stomach capacity, dumping, bile gastritis, afferent loop syndrome, efferent loop syndrome, anemia, metabolic bone disease, postprandial syndrome, peptic ulcer disease, vagotomy, partial gastric resection, stomach surgery, Nissen fundoplication, rapid gastric emptying, gastrojejunostomy, bloating, explosive diarrhea, early satiety, epigastric fullness, crampy abdominal pain, syncope, borborygmi, Sigstad's diagnostic index, Visick classification
Differential Diagnoses & Workup: Dumping Syndrome