Further Inpatient Care
- Usually, the workup and treatment are performed in an outpatient setting.
- Patients in whom medical management fails and who require operative intervention should have routine postoperative care based on the procedure performed.
Further Outpatient Care
- Patients need close follow-up care upon the initiation of therapy or with a change in therapy.
- Patients should be monitored for improvements in symptoms and for adverse effects of the medications.
- Patients in whom medical management fails should be referred to a thoracic surgeon for possible operative intervention.
Inpatient & Outpatient Medications
- Calcium channel blockers and nitrates are first-line therapy.
Complications
- Potential problems are based on the therapy. All medications have possible adverse effects, and patients should be monitored.
- Esophageal perforation can occur with esophageal dilatation, leading to admission to the hospital, time lost from work, and possible surgery.
- Operative complications are the same as for any operation on the esophagus.
- Esophageal perforation can occur during the myotomy. If a perforation of the mucosa occurs, the defect should be closed and the patient should have a contrast swallowing test prior to resuming a diet.
- Vagal injury can occur during the dissection.
- Other postoperative complications include wound infection, atelectasis, pneumonia, and persistent air leak.
- Any complication of a thoracic operation or an esophageal operation can occur.
Prognosis
- Prognosis is moderate. Symptom scores improve over time (3 y or longer) from DES and nutcracker esophagus.
- The mortality rate is minuscule, but the morbidity rate is high.
- No treatment is effective in all patients. Some patients do not respond to any treatment.
- In most patients, symptoms are controllable with a combination of treatment modalities.
Patient Education
- Patients should be educated about the symptoms and treatment options for the disease.
- Patient involvement and education are crucial to the success of any treatment modality.
- For excellent patient education resources, visit eMedicine's Procedures Center. Also, see eMedicine's patient education article BOTOX® Injections.
Smout AJ. Advances in esophageal motor disorders. Curr Opin Gastroenterol. Jul 2008;24(4):485-9. [Medline].
Almansa C, Hinder RA, Smith CD, Achem SR. A comprehensive appraisal of the surgical treatment of diffuse esophageal spasm. J Gastrointest Surg. Jun 2008;12(6):1133-45. [Medline].
Grubel C, Borovicka J, Schwizer W, Fox M, Hebbard G. Diffuse esophageal spasm. Am J Gastroenterol. Feb 2008;103(2):450-7. [Medline].
Almansa C, Achem SR. [Diffuse esophageal spasm (DES). Practical concepts of diagnosis and treatment] [Spanish]. Rev Gastroenterol Mex. Apr-Jun 2007;72(2):136-45. [Medline].
Almansa C, Heckman MG, Devault KR, Bouras E, Achem SR. Esophageal spasm: demographic, clinical, radiographic, and manometric features in 108 patients. Dis Esophagus. Sep 23 2011;[Medline].
Managing diffuse oesophageal spasm. Drug Ther Bull. May 2011;49(5):54-7; quiz i-ii. [Medline].
Nino-Murcia M, Stark P, Triadafilopoulos G. Esophageal wall thickening: a CT finding in diffuse esophageal spasm. J Comput Assist Tomogr. Mar-Apr 1997;21(2):318-21. [Medline].
Pandolfino JE, Fox MR, Bredenoord AJ, Kahrilas PJ. High-resolution manometry in clinical practice: utilizing pressure topography to classify oesophageal motility abnormalities. Neurogastroenterol Motil. Aug 2009;21(8):796-806. [Medline].
Herbella FA, Raz DJ, Nipomnick I, Patti MG. Primary versus secondary esophageal motility disorders: diagnosis and implications for treatment. J Laparoendosc Adv Surg Tech A. Apr 2009;19(2):195-8. [Medline].
Nguyen NQ, Ching K, Tippett M, Smout AJ, Holloway RH. Impact of nadir lower oesophageal sphincter pressure on bolus clearance assessed by combined manometry and multi-channel intra-luminal impedance measurement. Neurogastroenterol Motil. Aug 21 2009;[Medline].
Lacy BE, Weiser K. Esophageal motility disorders: medical therapy. J Clin Gastroenterol. May-Jun 2008;42(5):652-8. [Medline].
Salvador R, Costantini M, Rizzetto C, Zaninotto G. Diffuse esophageal spasm: the surgical approach. Dis Esophagus. Feb 10 2011;[Medline].
Bremner RM, DeMeester TR. Current management of patients with esophageal motor abnormalities. Adv Surg. 1996;30:349-84. [Medline].
Cameron R, Barclay M, Dobbs B. Ambulatory oesophageal manometry and pH monitoring for investigation of chest pain: a New Zealand experience. N Z Med J. Mar 10, 2006;119(1230):U1877. [Medline].
Cannon RO 3rd, Quyyumi AA, Mincemoyer R, Stine AM, Gracely RH, Smith WB, et al. Imipramine in patients with chest pain despite normal coronary angiograms. N Engl J Med. May 19 1994;330(20):1411-7. [Medline].
Casselbrant A, Edebo A, Wennerblom J, Lonroth H, Helander HF, Vieth M, et al. Actions by angiotensin II on esophageal contractility in humans. Gastroenterology. Nov 2006;132(1):249-60. [Medline].
Dogan I, Mittal RK. Esophageal motor disorders: recent advances. Curr Opin Gastroenterol. Jul 2006;22(4):417-22. [Medline].
Dogan I, Puckett JL, Padda BS, Mittal RK. Prevalence of increased esophageal muscle thickness in patients with esophageal symptoms. Am J Gastroenterol. Jan 2007;102(1):137-45. [Medline].
Drenth JP, Bos LP, Engels LG. Efficacy of diltiazem in the treatment of diffuse oesophageal spasm. Aliment Pharmacol Ther. Aug 1990;4(4):411-6. [Medline].
Eslick GD, Coulshed DS, Talley NJ. Diagnosis and treatment of noncardiac chest pain. Nat Clin Pract Gastroenterol Hepatol. Oct 2005;2(10):463-472. [Medline].
Fass R, Pulliam G, Johnson C. Symptom severity and oesophageal chemosensitivity to acid in older and young patients with gastro-oesophageal reflux. Age Ageing. Mar 2000;29(2):125-30.
Faybush EM, Fass R. Gastroesophageal reflux disease in noncardiac chest pain. Gastroenterol Clin North Am. Mar 2004;33(1):41-54. [Medline].
Ferguson TB, Woodbury JD, Roper CL, Burford TH. Giant muscular hypertrophy of the esophagus. Ann Thorac Surg. Sep 1969;8(3):209-18. [Medline].
Howden CW. Review article: pharmacological approaches to the optimal control of nocturnal intragastric acidity. Aliment Pharmacol Ther. Sept 2006;3:39-45.
Irving JD, Owen WJ, Linsell J, McCullagh M, Keightley A, Anggiansah A. Management of diffuse esophageal spasm with balloon dilatation. Gastrointest Radiol. 1992;17(3):189-92. [Medline].
Kamath MV, May A, Hollerbach S, Fitzpatrick D, Bulat R, Bajwa A, et al. Effects of esophageal stimulation in patients with functional disorders of the gastrointestinal tract. Crit Rev Biomed Eng. 2000;28(1-2):87-93. [Medline].
Makk LJ, Leesar M, Joseph A, Prince CP, Wright RA. Cardioesophageal reflexes: an invasive human study. Dig Dis Sci. Dec 2000;45(12):2451-4. [Medline].
Manfrini O, Bazzocchi G, Luati A, Borghi A, Monari P, Bugiardini R. Coronary spasm reflects inputs from adjacent esophageal system. Am J Physiol Heart Circ Physiol. May 2006;290(5):H2085-91. [Medline].
Mellow MH, Simpson AG, Watt L, Schoolmeester L, Haye OL. Esophageal acid perfusion in coronary artery disease. Induction of myocardial ischemia. Gastroenterology. Aug 1983;85(2):306-12. [Medline].
Miller LS, Parkman HP, Schiano TD, Cassidy MJ, Ter RB, Dabezies MA, et al. Treatment of symptomatic nonachalasia esophageal motor disorders with botulinum toxin injection at the lower esophageal sphincter. Dig Dis Sci. Oct 1996;41(10):2025-31. [Medline].
Mittal RK. Motor and sensory function of the esophagus: revelations through ultrasound and imaging. J Clin Gastroenterol. Apr/2005;39(4 Suppl 2):S42-8.
Mittal RK, Kassab G, Puckett JL, Liu J. Hypertrophy of the muscularis propria of the lower esophageal sphincter and the body of the esophagus in patients with primary motility disorders of the esophagus. Am J Gastroenterol. 2003;98(8):1705-12. [Medline].
Nayar DS, Khandwala F, Achkar E, Shay SS, Richter JE, Falk GW, et al. Esophageal manometry: assessment of interpreter consistency. Clin Gastroenterol Hepatol. Mar 2005;3(3):218-24. [Medline].
Pope CE 2nd. The esophagus for the nonesophagologist. Am J Med. Nov 24 1997;103(5A):19S-22S. [Medline].
Rencoret G, Csendes A, Henríquez A. [Esophageal manometry in patients with non cardiac chest pain]. Rev Med Chil. Mar 2006;134(3):291-8. [Medline].
Rieder F, Cheng L, Harnett KM, Chak A, Cooper GS, Isenberg G, et al. Gastroesophageal reflux disease- associated esophagitis induces endogenous cytokine production leading to motor abnormalities. Gastroenterology. Jan 2007;132(1):154-65. [Medline].
Santos R, Haack HG, Maddalena D, Hansen RD, Kellow JE. Evaluation of artificial neural networks in the classification of primary oesophageal dysmotility. Scand J Gastroenterol. Mar 2006;41(3):257-63. [Medline].
Sifrim D, Janssens J, Vantrappen G. Failing deglutitive inhibition in primary esophageal motility disorders. Gastroenterology. Apr 1994;106(4):875-82. [Medline].
Spencer HL, Smith L, Riley SA. A questionnaire study to assess long-term outcome in patients with abnormal esophageal manometry. Dysphagia. Jul 2006;21(3):149-55. [Medline].
Swamy N. Esophageal spasm: clinical and manometric response to nitroglycerine and long acting nitrites. Gastroenterology. Jan 1977;72(1):23-7. [Medline].
Tutuian R, Mainie I, Agrawal A, Gideon RM, Katz PO, Castell DO. Symptom and function heterogenicity among patients with distal esophageal spasm: studies using combined impedance-manometry. Am J Gastroenterol. Mar 2006;101(3):464-9. [Medline].
Vaezi MF. Review article: the role of pH monitoring in extraoesophageal gastro-oesophageal reflux disease. Aliment Pharmacol Ther. Mar 2006;23 Suppl 1:40-9. [Medline].
Winters C, Artnak EJ, Benjamin SB, Castell DO. Esophageal bougienage in symptomatic patients with the nutcracker esophagus. A primary esophageal motility disorder. JAMA. Jul 20 1984;252(3):363-6. [Medline].

