Gastric Ulcers: Multimedia

References

1. Musumba C, Pritchard DM, Pirmohamed M. Review article: Cellular and molecular mechanisms of NSAID-induced peptic ulceration. Aliment Pharmacol Ther. Jul 3 2009;[Medline].

2. Sadic J, Borgström A, Manjer J, Toth E, Lindell G. Bleeding peptic ulcer - time trends in incidence, treatment and mortality in Sweden. Aliment Pharmacol Ther. Aug 15 2009;30(4):392-8. [Medline].

3. Taha AS, McCloskey C, Prasad R, Bezlyak V. Famotidine for the prevention of peptic ulcers and oesophagitis in patients taking low-dose aspirin (FAMOUS): a phase III, randomised, double-blind, placebo-controlled trial. Lancet. Jul 11 2009;374(9684):119-25. [Medline].

4. Baldwin CM, Keam SJ. Rabeprazole: a review of its use in the management of gastric acid-related diseases in adults. Drugs. 2009;69(10):1373-401. [Medline].

5. Chan KL, Ching YL, Hung CY. Clopidogrel versus aspirin and esomeprazole to prevent ulcer bleeding. N Eng J Med. 2005;352:238-44. [Full Text].

6. Lai KC, Chu KM, Hui WM, et al. Esomeprazole with aspirin versus clopidogrel for prevention of recurrent gastrointestinal ulcer complications. Clin Gastroenterol Hepatol. Jul 2006;4(7):860-5. [Medline].

7. Wang HM, Hsu PI, Lo GH, Chen TA, Cheng LC, Chen WC, et al. Comparison of Hemostatic Efficacy for Argon Plasma Coagulation and Distilled Water Injection in Treating High-risk Bleeding Ulcers. J Clin Gastroenterol. May 14 2009;[Medline].

8. [Best Evidence] Ford AC, Delaney BC, Forman D, Moayyedi P. Eradication therapy for peptic ulcer disease in Helicobacter pylori positive patients. Cochrane Database Syst Rev. 2006;(2):CD003840. [Medline].

9. Graham DY, Klein PD. Accurate diagnosis of Helicobacter pylori. 13C-urea breath test. Gastroenterol Clin North Am. Dec 2000;29(4):885-93, x. [Medline].

10. Jensen DM. Management of severe ulcer rebleeding. N Engl J Med. Mar 11 1999;340(10):799-801. [Medline].

11. Lai KC, Lam SK, Chu KM, Wong BC, Hui WM, Hu WH. Lansoprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin use. N Engl J Med. Jun 27 2002;346(26):2033-8. [Medline].

12. Lau JY, Chung SC. Surgery in the acute management of bleeding peptic ulcer. Baillieres Best Pract Res Clin Gastroenterol. Jun 2000;14(3):505-18. [Medline].

13. Lau YW, Sung JY, Lee KC. Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers. N Eng J Med. 2000;343:310-6. [Full Text].

14. Lo CC, Hsu PI, Lo GH, et al. Comparison of hemostatic efficacy for epinephrine injection alone and injection combined with hemoclip therapy in treating high-risk bleeding ulcers. Gastrointest Endosc. May 2006;63(6):767-73. [Medline].

15. Silverstein FE, Faich G, Goldstein JL, et al. Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study. JAMA. 284(10):1247-55. [Medline].

16. Soll AH. Consensus conference. Medical treatment of peptic ulcer disease. Practice guidelines. Practice Parameters Committee of the American College of Gastroenterology. JAMA. Feb 28 1996;275(8):622-9. [Medline].

17. Sonnenberg A, Everhart JE. Health impact of peptic ulcer in the United States. Am J Gastroenterol. Apr 1997;92(4):614-20. [Medline].

18. Steinbach G, Ford R, Glober G, et al. Antibiotic treatment of gastric lymphoma of mucosa-associated lymphoid tissue. An uncontrolled trial. Ann Intern Med. Jul 20 1999;131(2):88-95. [Medline].

19. Suerbaum S, Michetti P. Helicobacter pylori infection. N Engl J Med. Oct 10 2002;347(15):1175-86. [Medline].

20. Vaira D, Gatta L, Ricci C, et al. Peptic ulcer and Helicobacter pylori: update on testing and treatment. Postgrad Med. Jun 2005;117(6):17-22, 46. [Medline].

21. Wallace JL. Recent advances in gastric ulcer therapeutics. Curr Opin Pharmacol. Dec 2005;5(6):573-7. [Medline].

22. Yang YX, Lewis JD, Epstein S, Metz DC. Long-term proton pump inhibitor therapy and risk of hip fracture. JAMA. Dec 27 2006;296(24):2947-53. [Medline].

23. [Best Evidence] van Rensburg C, Barkun AN, Racz I, et al. Clinical trial: intravenous pantoprazole vs. ranitidine for the prevention of peptic ulcer rebleeding: a multicentre, multinational, randomized trial. Aliment Pharmacol Ther. Mar 1 2009;29(5):497-507. [Medline].

Further Reading

Related eMedicine Topics

• Gastric Ulcer [in the Radiology section]
• Duodenum, Ulcers [in the Radiology section]
• Intestinal Perforation [in the General Surgery section]
• Perforated Peptic Ulcer [in the General Surgery section]
• Peptic Ulcer Disease [in the Gastroenterology section]
• Peptic Ulcer Disease [in the Pediatrics: General Medicine section]

Clinical trials

• Comparison of Intravenous Pantoprazole and Famotidine for Stress Ulcer Prophylaxis
• Cytokine Gene Polymorphisms in Gastric Diseases
• Effect of Selective COX-2 Inhibition on Ulcer Healing
• H. Pylori Eradication on Healing of Iatrogenic Gastric Ulcer by Endoscopic Mucosal Resection
• Study to Evaluate the Incidence of Gastric Ulcers Following Administration of Either PA32540 or Enteric Coated Aspirin 325 mg in Subjects Who Are at Risk for Developing Aspirin-Associated Ulcers

National Guideline Clearinghouse

• ACR Appropriateness Criteria® hematemesis. American College of Radiology - Medical Specialty Society. 1998 (revised 2006). 7 pages. NGC:005111
• Management of acute upper and lower gastrointestinal bleeding. A national clinical guideline. Scottish Intercollegiate Guidelines Network - National Government Agency [Non-U.S.]. 2008 Sep. 57 pages. NGC:006730
• Management of helicobacter pylori infection. Gastroenterological Society of Singapore - Medical Specialty Society; Singapore Ministry of Health - National Government Agency [Non-U.S.]. 2004 Sep. 25 pages. NGC:003916
• Nausea and vomiting. Association of Comprehensive Cancer Centres - Disease Specific Society. 2006 Jan. 28 pages. NGC:006067
• Quality indicators for esophagogastroduodenoscopy. American College of Gastroenterology - Medical Specialty Society; American Society for Gastrointestinal Endoscopy - Medical Specialty Society. 2006 Apr. 6 pages. NGC:004966

Keywords

gastric ulcers, ulcers, peptic ulcer disease, PUD, peptic ulcer, Helicobacter pylori infection, H pylori infection, NSAID toxicity, nonsteroidal anti-inflammatory drug toxicity, Zollinger-Ellison syndrome, ZES, gastrinoma, gastric cancer, stomach ulcer, GI ulcer, gastrointestinal ulcer, gastric ulcer, duodenal ulcer, cigarette smoking, gastroduodenal ulcer, hypersecretion of gastric acid, chronic renal insufficiency, diabetes, ulcer pain, epigastric pain, hematemesis, melena, presyncope, peritonitis, gastric perforation

Contributor Information and Disclosures

Author

Sanjeeb Shrestha, MD, Consulting Staff, Division of Gastroenterology, North West Arkansas Gastroenterology Clinic
Sanjeeb Shrestha, MD is a member of the following medical societies: American College of Gastroenterology, American Gastroenterological Association, and American Society of Gastrointestinal Endoscopy
Disclosure: Nothing to disclose.

Coauthor(s)

Daryl Lau, MD, MPH, FRCP(C), Director of Translational Liver Research, Beth Israel Deaconess Medical Center; Associate Professor of Medicine, Harvard Medical School
Daryl Lau, MD, MPH, FRCP(C) is a member of the following medical societies: American Association for the Study of Liver Diseases and American Gastroenterological Association
Disclosure: Nothing to disclose.

Medical Editor

David Greenwald, MD, Fellowship Program Director, Associate Professor, Department of Medicine, Division of Gastroenterology, Montefiore Medical Center, Albert Einstein College of Medicine
David Greenwald, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Gastroenterology, American College of Physicians, American Gastroenterological Association, and American Society for Gastrointestinal Endoscopy
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: eMedicine Salary Employment

Managing Editor

Simmy Bank, MD, Chair, Professor, Department of Internal Medicine, Division of Gastroenterology, Long Island Jewish Hospital, Albert Einstein College of Medicine
Disclosure: Nothing to disclose.

CME Editor

Alex J Mechaber, MD, FACP, Associate Dean for Undergraduate Medical Education, Associate Professor of Medicine, University of Miami Miller School of Medicine
Alex J Mechaber, MD, FACP is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians-American Society of Internal Medicine, and Society of General Internal Medicine
Disclosure: Nothing to disclose.

Chief Editor

Julian Katz, MD, Clinical Professor of Medicine, Drexel University College of Medicine; Consulting Staff, Department of Medicine, Section of Gastroenterology and Hepatology, Hospital of the Medical College of Pennsylvania
Julian Katz, MD is a member of the following medical societies: American College of Gastroenterology, American College of Physicians, American Gastroenterological Association, American Geriatrics Society, American Medical Association, American Society for Gastrointestinal Endoscopy, American Society of Law Medicine and Ethics, American Trauma Society, Association of American Medical Colleges, and Physicians for Social Responsibility
Disclosure: Nothing to disclose.