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Hydatid Cysts Medication

  • Author: Imad S Dandan, MD; Chief Editor: BS Anand, MD  more...
 
Updated: Aug 19, 2014
 

Medication Summary

Drug therapy for echinococcosis is limited. The anthelmintic benzimidazoles, namely albendazole and mebendazole, are used for treatment and prophylaxis. Praziquantel, an isoquinoline derivative, is used as an adjunct for therapy.

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Anthelmintics

Class Summary

Treatment of Echinococcus infestation as a primary modality or adjunct to surgery.

Albendazole (Albenza)

 

Decreases ATP production in worm, causing energy depletion, immobilization, and, finally, death. Orally administered broad-spectrum anthelmintic with poor aqueous solubility. Poorly absorbed from GI tract but metabolized quickly to albendazole sulfoxide, which is easily absorbed. Systemic activity is attributed to first metabolite. Plasma level is noted to rise significantly (as much as 5-fold) when ingested after high-fat meal. Experience with patients < 6 y is limited.

Mebendazole (Vermox)

 

Causes worm death by selectively and irreversibly blocking uptake of glucose and other nutrients in susceptible adult intestine where helminths dwell. Broad-spectrum synthetic anthelmintic. Metabolites are devoid of anthelmintic activity.

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Trematodicides

Class Summary

Used to potentiate effect of benzimidazoles during therapy.

Praziquantel (Biltricide)

 

Increases cell membrane permeability in susceptible worms, resulting in loss of intracellular calcium, massive contractions, and paralysis of musculature. In addition, produces vacuolization and disintegration of schistosome tegument. This is followed by attachment of phagocytes to parasite and death. Isoquinoline derivative that is easily absorbed through GI tract.

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Contributor Information and Disclosures
Author

Imad S Dandan, MD Chief of Trauma Section, Scripps Memorial Hospital La Jolla, California

Imad S Dandan, MD is a member of the following medical societies: American Association for the Surgery of Trauma, American College of Surgeons, American Medical Association, California Medical Association, American Trauma Society, Society of Critical Care Medicine

Disclosure: Nothing to disclose.

Coauthor(s)

Assaad M Soweid, MD, FACG, FASGE Associate Professor of Clinical Medicine, Endosonography and Advanced Therapeutic Endoscopy, Director, Endoscopy-Bronchoscopy Unit, Division of Gastroenterology, Department of Internal Medicine, American University of Beirut Medical Center, Lebanon

Assaad M Soweid, MD, FACG, FASGE is a member of the following medical societies: American College of Gastroenterology, American College of Physicians, American College of Physicians-American Society of Internal Medicine, American Medical Association

Disclosure: Nothing to disclose.

Firass Abiad, MD Fellow in Minimally Invasive Surgery, Department of Surgery, University of Tennessee

Disclosure: Nothing to disclose.

Specialty Editor Board

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Chief Editor

BS Anand, MD Professor, Department of Internal Medicine, Division of Gastroenterology, Baylor College of Medicine

BS Anand, MD is a member of the following medical societies: American Association for the Study of Liver Diseases, American College of Gastroenterology, American Gastroenterological Association, American Society for Gastrointestinal Endoscopy

Disclosure: Nothing to disclose.

Additional Contributors

Ann Ouyang, MBBS Professor, Department of Internal Medicine, Pennsylvania State University College of Medicine; Attending Physician, Division of Gastroenterology and Hepatology, Milton S Hershey Medical Center

Disclosure: Nothing to disclose.

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