eMedicine Specialties > Gastroenterology > Liver
Hyperbilirubinemia, Conjugated: Treatment & Medication
Updated: Feb 16, 2009
- Overview
- Differential Diagnoses & Workup
- Treatment & Medication
- Follow-up
Treatment
Consultations
- In most patients, the cause of conjugated hyperbilirubinemia is apparent, such as those with viral hepatitis or sepsis.
- When this is not the case or when multiple causes are possible, consultation with a gastroenterologist or hepatologist may be helpful.
More on Hyperbilirubinemia, Conjugated |
| Overview: Hyperbilirubinemia, Conjugated |
| Differential Diagnoses & Workup: Hyperbilirubinemia, Conjugated |
Treatment & Medication: Hyperbilirubinemia, Conjugated |
| Follow-up: Hyperbilirubinemia, Conjugated |
| References |
| « Previous Page | Next Page » |
References
Lathe GH. The degradation of haem by mammals and its excretion as conjugated bilirubin. Essays Biochem. 1972;8:107-48. [Medline].
Muraca M, Fevery J, Blanckaert N. Analytic aspects and clinical interpretation of serum bilirubins. Semin Liver Dis. May 1988;8(2):137-47. [Medline].
Westwood A. The analysis of bilirubin in serum. Ann Clin Biochem. Mar 1991;28 (pt 2):119-30. [Medline].
Iyanagi T, Emi Y, Ikushiro S. Biochemical and molecular aspects of genetic disorders of bilirubin metabolism. Biochim Biophys Acta. Sep 30 1998;1407(3):173-84. [Medline].
Johnston DE. Special considerations in interpreting liver function tests. Am Fam Physician. Apr 15 1999;59(8):2223-30. [Medline]. [Full Text].
Blanckaert N, Servaes R, Leroy P. Measurement of bilirubin-protein conjugates in serum and application to human and rat sera. J Lab Clin Med. Aug 1986;108(2):77-87. [Medline].
Doumas BT, Wu TW. The measurement of bilirubin fractions in serum. Crit Rev Clin Lab Sci. 1991;28(5-6):415-45. [Medline].
Faust TW, Reddy KR. Postoperative jaundice. Clin Liver Dis. Feb 2004;8(1):151-66. [Medline].
Fevery J, Muraca M, Mesa V, et al. Plasma bilirubin pigments in health and disease. Mol Aspects Med. 1987;9(5):391-404. [Medline].
[Best Evidence] Jangaard KA, Fell DB, Dodds L, Allen AC. Outcomes in a population of healthy term and near-term infants with serum bilirubin levels of >or=325 micromol/L (>or=19 mg/dL) who were born in Nova Scotia, Canada, between 1994 and 2000. Pediatrics. Jul 2008;122(1):119-24. [Medline].
Jansen PL, Muller M. Early events in sepsis-associated cholestasis. Gastroenterology. Feb 1999;116(2):486-8. [Medline].
Jedlitschky G, Leier I, Buchholz U, et al. ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2. Biochem J. Oct 1 1997;327 (pt 1):305-10. [Medline]. [Full Text].
Kamisako T, Leier I, Cui Y, et al. Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2. Hepatology. Aug 1999;30(2):485-90. [Medline]. [Full Text].
Kirk JM. Neonatal jaundice: a critical review of the role and practice of bilirubin analysis. Ann Clin Biochem. Sep 2008;45:452-62. [Medline].
Korenblat KM, Berk PD. Hyperbilirubinemia in the setting of antiviral therapy. Clin Gastroenterol Hepatol. Apr 2005;3(4):303-10. [Medline].
McKiernan PJ. Neonatal cholestasis. Semin Neonatol. Apr 2002;7(2):153-65. [Medline].
Mews C, Sinatra FR. Cholestasis in infancy. Pediatr Rev. Jun 1994;15(6):233-40; quiz 240. [Medline].
Moyer V, Freese DK, Whitington PF, et al. Guideline for the evaluation of cholestatic jaundice in infants: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. Aug 2004;39(2):115-28. [Medline].
Muraca M, Fevery J, Blanckaert N. Relationships between serum bilirubins and production and conjugation of bilirubin. Studies in Gilbert's syndrome, Crigler-Najjar disease, hemolytic disorders, and rat models. Gastroenterology. Feb 1987;92(2):309-17. [Medline].
Nowicki MJ, Poley JR. The hereditary hyperbilirubinaemias. Baillieres Clin Gastroenterol. Jun 1998;12(2):355-67. [Medline].
Qualmann K, Rehage J, Scholz H. Measurement of bilirubin by HPLC in bovine plasma--a comparison with the conventional diazo-method. Dtsch Tierarztl Wochenschr. Sep 1997;104(9):354-8. [Medline].
Roche SP, Kobos R. Jaundice in the adult patient. Am Fam Physician. Jan 15 2004;69(2):299-304. [Medline]. [Full Text].
te Boekhorst T, Urlus M, Doesburg W, Yap SH, Goris RJ. Etiologic factors of jaundice in severely ill patients. A retrospective study in patients admitted to an intensive care unit with severe trauma or with septic intra-abdominal complications following surgery and without evidence of bile duct obstruction. J Hepatol. Aug 1988;7(1):111-7. [Medline].
The familial conjugated hyperbilirubinemias. Semin Liver Dis. Nov 1994;14(4):386-94. [Medline].
Venigalla S, Gourley GR. Neonatal cholestasis. Semin Perinatol. Oct 2004;28(5):348-55. [Medline].
Zimniak P. Dubin-Johnson and Rotor syndromes: molecular basis and pathogenesis. Semin Liver Dis. Aug 1993;13(3):248-60. [Medline].
Further Reading
Keywords
conjugated hyperbilirubinemia, hyperbilirubinemia, icterus, jaundice, kernicterus, bilirubin accumulation, bilirubin formation, tetrapyrrole, hemoglobin, unconjugated bilirubin, conjugated bilirubin, liver disease, biliary disease
Treatment & Medication: Hyperbilirubinemia, Conjugated