Laboratory Studies
- Laboratory studies and blood work should focus on evaluations for infectious, electrolytic, and metabolic derangements.
Imaging Studies
- On plain abdominal radiographs, ileus appears as copious gas dilatation of the small intestine and colon. With enteroclysis, the contrast medium in patients with paralytic ileus should reach the cecum within 4 hours; if the contrast medium remains stationary for longer than 4 hours, mechanical obstruction is suggested.[15]
Livingston EH, Passaro EP Jr. Postoperative ileus. Dig Dis Sci. Jan 1990;35(1):121-32. [Medline].
Shibata Y, Toyoda S, Nimura Y, Miyati M. Patterns of intestinal motility recovery during the early stage following abdominal surgery: clinical and manometric study. World J Surg. Oct 1997;21(8):806-9; discussion 809-10. [Medline].
Holte K, Kehlet H. Postoperative ileus: a preventable event. Br J Surg. Nov 2000;87(11):1480-93. [Medline].
Vasquez W, Hernandez AV, Garcia-Sabrido JL. Is gum chewing useful for ileus after elective colorectal surgery? A systematic review and meta-analysis of randomized clinical trials. J Gastrointest Surg. Apr 2009;13(4):649-56. [Medline].
Resnick J, Greenwald DA, Brandt LJ. Delayed gastric emptying and postoperative ileus after nongastric abdominal surgery: part I. Am J Gastroenterol. May 1997;92(5):751-62. [Medline].
Resnick J, Greenwald DA, Brandt LJ. Delayed gastric emptying and postoperative ileus after nongastric abdominal surgery: part II. Am J Gastroenterol. Jun 1997;92(6):934-40. [Medline].
Kalff JC, Schraut WH, Simmons RL, Bauer AJ. Surgical manipulation of the gut elicits an intestinal muscularis inflammatory response resulting in postsurgical ileus. Ann Surg. Nov 1998;228(5):652-63. [Medline].
Boeckxstaens GE, de Jonge WJ. Neuroimmune mechanisms in post-operative ileus. Gut. Sept 2009;58(9):1300-11.
Espat NJ, Cheng G, Kelley MC, Vogel SB, Sninsky CA, Hocking MP. Vasoactive intestinal peptide and substance P receptor antagonists improve postoperative ileus. J Surg Res. Jun 1995;58(6):719-23. [Medline].
Kalff JC, Schraut WH, Billiar TR, Simmons RL, Bauer AJ. Role of inducible nitric oxide synthase in postoperative intestinal smooth muscle dysfunction in rodents. Gastroenterology. Feb 2000;118(2):316-27. [Medline].
Senagore AJ. Pathogenesis and clinical and economic consequences of postoperative ileus. Am J Health Syst Pharm. Oct 15 2007;64(20 Suppl 13):S3-7. [Medline].
Cameron JL, ed. Current Surgical Therapy. 7th ed. Chicago: Mosby; 2001.
Tollesson PO, Cassuto J, Rimbäck G. Patterns of propulsive motility in the human colon after abdominal operations. Eur J Surg. Apr 1992;158(4):233-6. [Medline].
Loftus CG, Harewood GC, Baron TH. Assessment of predictors of response to neostigmine for acute colonic pseudo-obstruction. Am J Gastroenterol. Dec 2002;97(12):3118-22. [Medline].
Schwartz SI, ed. Principles of Surgery. 7th ed. New York, NY: McGraw-Hill; 1999.
Cali RL, Meade PG, Swanson MS, Freeman C. Effect of Morphine and incision length on bowel function after colectomy. Dis Colon Rectum. Feb 2000;43(2):163-8. [Medline].
Ferraz AA, Cowles VE, Condon RE, Carilli S, Ezberci F, Frantzides CT, et al. Nonopioid analgesics shorten the duration of postoperative ileus. Am Surg. Dec 1995;61(12):1079-83. [Medline].
Purkayastha S, Tilney HS, Darzi AW, Tekkis PP. Meta-analysis of randomized studies evaluating chewing gum to enhance postoperative recovery following colectomy. Arch Surg. Aug 2008;143(8):788-93. [Medline].
Shang H, Yang Y, Tong X, et al. Gum chewing slightly enhances early recovery from postoperative ileus after cesarean section: results of a prospective, randomized, controlled trial. Am J Perinatol. Dec 11 2009;epub ahead of print. [Medline].
Waldhausen JH, Schirmer BD. The effect of ambulation on recovery from postoperative ileus. Ann Surg. Dec 1990;212(6):671-7. [Medline].
Zingg U, Miskovic D, Hamel CT, Erni L, Oertli D, Metzger U. Influence of thoracic epidural analgesia on postoperative pain relief and ileus after laparoscopic colorectal resection : Benefit with epidural analgesia. Surg Endosc. Feb 2009;23(2):276-82. [Medline].
Liu SS, Carpenter RL, Mackey DC, Thirlby RC, Rupp SM, Shine TS, et al. Effects of perioperative analgesic technique on rate of recovery after colon surgery. Anesthesiology. Oct 1995;83(4):757-65. [Medline].
Mann C, Pouzeratte Y, Boccara G, Peccoux C, Vergne C, Brunat G, et al. Comparison of intravenous or epidural patient-controlled analgesia in the elderly after major abdominal surgery. Anesthesiology. Feb 2000;92(2):433-41. [Medline].
[Best Evidence] Marret E, Rolin M, Beaussier M, Bonnet F. Meta-analysis of intravenous lidocaine and postoperative recovery after abdominal surgery. Br J Surg. Nov 2008;95(11):1331-8. [Medline].
Becker G, Blum HE. Novel opioid antagonists for opioid-induced bowel dysfunction and postoperative ileus. Lancet. Apr 4 2009;373(9670):1198-206. [Medline].
Maron DJ, Fry RD. New therapies in the treatment of postoperative ileus after gastrointestinal surgery. Am J Ther. Jan-Feb 2008;15(1):59-65. [Medline].
Yuan CS, Foss JF, Osinski J, Toledano A, Roizen MF, Moss J. The safety and efficacy of oral methylnaltrexone in preventing morphine-induced delay in oral-cecal transit time. Clin Pharmacol Ther. Apr 1997;61(4):467-75. [Medline].
Candy B, Jones L, Goodman ML, Drake R, Tookman A. Laxatives or methylnaltrexone for the management of constipation in palliative care patients. Cochrane Database Syst Rev. Jan 19 2011;CD003448. [Medline].
Taguchi A, Sharma N, Saleem RM, Sessler DI, Carpenter RL, Seyedsadr M, et al. Selective postoperative inhibition of gastrointestinal opioid receptors. N Engl J Med. Sep 27 2001;345(13):935-40. [Medline].
[Best Evidence] Tan EK, Cornish J, Darzi AW, Tekkis PP. Meta-analysis: Alvimopan vs. placebo in the treatment of post-operative ileus. Aliment Pharmacol Ther. Jan 1 2007;25(1):47-57. [Medline].
Senagore AJ, Bauer JJ, Du W, Techner L. Alvimopan accelerates gastrointestinal recovery after bowel resection regardless of age, gender, race, or concomitant medication use. Surgery. Oct 2007;142(4):478-86. [Medline].
Zingg U, Miskovic D, Pasternak I, Meyer P, Hamel CT, Metzger U. Effect of bisacodyl on postoperative bowel motility in elective colorectal surgery: a prospective, randomized trial. Int J Colorectal Dis. Dec 2008;23(12):1175-83. [Medline].
Wiriyakosol S, Kongdan Y, Euanorasetr C, Wacharachaisurapol N, Lertsithichai P. Randomized controlled trial of bisacodyl suppository versus placebo for postoperative ileus after elective colectomy for colon cancer. Asian J Surg. Jul 2007;30(3):167-72. [Medline].
Traut U, Brügger L, Kunz R, Pauli-Magnus C, Haug K, Bucher HC, et al. Systemic prokinetic pharmacologic treatment for postoperative adynamic ileus following abdominal surgery in adults. Cochrane Database Syst Rev. Jan 23 2008;CD004930. [Medline].
Wattchow DA, De Fontgalland D, Bampton PA, et al. Clinical trial: the impact of cyclooxygenase inhibitors on gastrointestinal recovery after major surgery - a randomized double blind controlled trial of celecoxib or diclofenac vs. placebo. Aliment Pharmacol Ther. Nov 15 2009;30(10):987-98. [Medline].
Yeh YC, Klinger EV, Reddy P. Pharmacologic options to prevent postoperative ileus. Ann Pharmacother. Sep 2009;43(9):1474-85. [Medline].
Abd-El-Maeboud KH, Ibrahim MI, Shalaby DA, Fikry MF. Gum chewing stimulates early return of bowel motility after caesarean section. BJOG. Sep 2009;116(10):1334-9. [Medline].
Iyer S, Saunders WB, Stemkowski S. Economic burden of postoperative ileus associated with colectomy in the United States. J Manag Care Pharm. Jul-Aug 2009;15(6):485-94. [Medline].
Bauer AJ, Boeckxstaens GE. Mechanisms of postoperative ileus. Neurogastroenterol Motil. Oct 2004;16 Suppl 2:54-60. [Medline].
Behm B, Stollman N. Postoperative ileus: etiologies and interventions. Clin Gastroenterol Hepatol. Mar 2003;1(2):71-80. [Medline].
Carter S. The surgical team and outcomes management: focus on postoperative ileus. J Perianesth Nurs. Apr 2006;21(2A Suppl):S2-6. [Medline].
Correia MI, da Silva RG. The impact of early nutrition on metabolic response and postoperative ileus. Curr Opin Clin Nutr Metab Care. Sep 2004;7(5):577-83. [Medline].
Delaney CP. Clinical perspective on postoperative ileus and the effect of opiates. Neurogastroenterol Motil. Oct 2004;16 Suppl 2:61-6. [Medline].
Delaney CP, Senagore AJ, Viscusi ER, Wolff BG, Fort J, Du W, et al. Postoperative upper and lower gastrointestinal recovery and gastrointestinal morbidity in patients undergoing bowel resection: pooled analysis of placebo data from 3 randomized controlled trials. Am J Surg. Mar 2006;191(3):315-9. [Medline].
Houwen RH, van der Doef HP, Sermet I, et al. Defining DIOS and constipation in cystic fibrosis with a multicentre study on the incidence, characteristics, and treatment of DIOS. J Pediatr Gastroenterol Nutr. Jan 2010;50(1):38-42. [Medline].
Jones MP, Wessinger S. Small intestinal motility. Curr Opin Gastroenterol. Mar 2006;22(2):111-6. [Medline].
Mattei P, Rombeau JL. Review of the pathophysiology and management of postoperative ileus. World J Surg. Aug 2006;30(8):1382-91. [Medline].
Miedema BW, Johnson JO. Methods for decreasing postoperative gut dysmotility. Lancet Oncol. Jun 2003;4(6):365-72. [Medline].
Milsom JW, Böhm B, Hammerhofer KA, Fazio V, Steiger E, Elson P. A prospective, randomized trial comparing laparoscopic versus conventional techniques in colorectal cancer surgery: a preliminary report. J Am Coll Surg. Jul 1998;187(1):46-54; discussion 54-5. [Medline].
Moore BA, Albers KM, Davis BM, Grandis JR, Togel S, Bauer AJ. Altered inflammatory gene expression underlies increased susceptibility to murine postoperative ileus with advancing age. Am J Physiol Gastrointest Liver Physiol. Jun 2007;292(6):G1650-9. [Medline].
[Best Evidence] Ng WQ, Neill J. Evidence for early oral feeding of patients after elective open colorectal surgery: a literature review. J Clin Nurs. Jun 2006;15(6):696-709. [Medline].
Nunley JC, FitzHarris GP. Postoperative ileus. Curr Surg. Jul-Aug 2004;61(4):341-5. [Medline].
Person B, Wexner SD. The management of postoperative ileus. Curr Probl Surg. Jan 2006;43(1):6-65. [Medline].
Saclarides TJ. Current choices--good or bad--for the proactive management of postoperative ileus: A surgeon's view. J Perianesth Nurs. Apr 2006;21(2A Suppl):S7-15. [Medline].
Saunders MD. Acute colonic pseudo-obstruction. Gastrointest Endosc Clin N Am. Apr 2007;17(2):341-60, vi-vii. [Medline].
[Best Evidence] Schuster R, Grewal N, Greaney GC, Waxman K. Gum chewing reduces ileus after elective open sigmoid colectomy. Arch Surg. Feb 2006;141(2):174-6. [Medline].
Sumi T, Katsumata K, Tsuchida A, et al. Evaluation of sequential organ failure assessment score for patients with strangulation ileus. Langenbecks Arch Surg. Jan 2010;395(1):27-31. [Medline].
Sutton DH, Harrell SP, Wo JM. Diagnosis and management of adult patients with chronic intestinal pseudoobstruction. Nutr Clin Pract. Feb 2006;21(1):16-22. [Medline].
| Ileus | Pseudo-obstruction | Mechanical Obstruction (Simple) | |
| Symptoms | Mild abdominal pain, bloating, nausea, vomiting, obstipation, constipation | Crampy abdominal pain, constipation, obstipation, nausea, vomiting, anorexia | Crampy abdominal pain, constipation, obstipation, nausea, vomiting, anorexia |
| Physical Examination Findings | Silent abdomen, distention, tympanic | Borborygmi, tympanic, peristaltic waves, hypoactive or hyperactive bowel sounds, distention, localized tenderness | Borborygmi, peristaltic waves, high-pitched bowel sounds, rushes, distention, localized tenderness |
| Plain Radiographs | Large and small bowel dilatation, diaphragm elevated | Isolated large bowel dilatation, diaphragm elevated | Bow-shaped loops in ladder pattern, paucity of colonic gas distal to lesion, diaphragm mildly elevated, air-fluid levels |

