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Gastrinoma Differential Diagnoses

  • Author: Jennifer Lynn Bonheur, MD; Chief Editor: BS Anand, MD  more...
Updated: Mar 02, 2016

Diagnostic Considerations

Antral G-cell hyperfunction and massive small intestine resection are other diagnostic considerations.

In a retrospective study, Rosentraeger et al noted differences in pathologic features and biologic behavior between gastrinomas and non-syndromic duodenal gastrin-producing neuroendocrine tumors (ns-gas-NETs) from 41 patients with gastrin-producing duodenal tumors.[7] Gastrinomas exhibited the following characteristics[7] :

  • Higher Ki-67 index (1.74%) than ns-gas-NETs (0.85%)
  • Increased incidence of lymph node metastases (75%) than ns-gas-NETs (6%)
  • Showed liver metastasis, resulting in more advanced disease (75%)—staged at TNM III or higher—than ns-gas-NETs (6%)
  • More often underwent surgical resection, whereas ns-gas-NETs were removed endoscopically

Differential Diagnoses

Contributor Information and Disclosures

Jennifer Lynn Bonheur, MD Attending Physician, Division of Gastroenterology, Lenox Hill Hospital

Jennifer Lynn Bonheur, MD is a member of the following medical societies: American Gastroenterological Association, American Society for Gastrointestinal Endoscopy, New York Society for Gastrointestinal Endoscopy, New York Academy of Sciences, Sigma Xi

Disclosure: Nothing to disclose.


Senthil Nachimuthu, MD, FACP 

Senthil Nachimuthu, MD, FACP is a member of the following medical societies: American College of Physicians

Disclosure: Nothing to disclose.

Specialty Editor Board

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Chief Editor

BS Anand, MD Professor, Department of Internal Medicine, Division of Gastroenterology, Baylor College of Medicine

BS Anand, MD is a member of the following medical societies: American Association for the Study of Liver Diseases, American College of Gastroenterology, American Gastroenterological Association, American Society for Gastrointestinal Endoscopy

Disclosure: Nothing to disclose.

Additional Contributors

Manoop S Bhutani, MD Professor, Co-Director, Center for Endoscopic Research, Training and Innovation (CERTAIN), Director, Center for Endoscopic Ultrasound, Department of Medicine, Division of Gastroenterology, University of Texas Medical Branch; Director, Endoscopic Research and Development, The University of Texas MD Anderson Cancer Center

Manoop S Bhutani, MD is a member of the following medical societies: American Association for the Advancement of Science, American College of Gastroenterology, American College of Physicians, American Gastroenterological Association, American Institute of Ultrasound in Medicine, American Society for Gastrointestinal Endoscopy

Disclosure: Nothing to disclose.


Simmy Bank, MD Chair, Professor, Department of Internal Medicine, Division of Gastroenterology, Long Island Jewish Hospital, Albert Einstein College of Medicine

Disclosure: Nothing to disclose.

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