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Breast Biopsy With Needle Localization 

  • Author: William Teh, MBChB, FRCR; more...
 
Updated: Dec 28, 2015
 

Detection of Breast Lesions

As breast cancer screening with mammography increases, many impalpable breast lesions are being detected. These lesions should first and foremost be definitively diagnosed by using image-guided needle biopsy. After needle biopsy, some of these lesions may require diagnostic or therapeutic surgical biopsy. If a malignant or indefinite diagnosis is obtained, surgical excision is indicated. This, in turn, requires accurate localization of the lesion, which is required to ensure correct and adequate removal of the lesions and to minimize the degree of cosmetic disfigurement.[1]

The following images depict the localization of masses on mammograms.

Mammogram shows a spiculated mass to be transfixed Mammogram shows a spiculated mass to be transfixed by the guidewire.
Orthogonal (mediolateral) projection confirms the Orthogonal (mediolateral) projection confirms the position of the needle to be placed beyond the cluster of microcalcification.

See Breast Lumps in Young Women: Diagnostic Approaches, a Critical Images slideshow, to help manage palpable breast lumps in young women.

See Breast Cancer Evaluation, Ultrasonography in Breast Cancer, Mammography in Breast Cancer, and Magnetic Resonance Mammography for more information on these topics.

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Indications for Needle Localization of Breast Lesions

Breast biopsy with needle localization is used for the diagnosis of impalpable breast lesions.

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Imaging and Localization Considerations

The modality of choice depends on operator expertise and the type of lesion. Most palpable lesions do not require image-guided localization. Breast lesions that are visible with ultrasonography can be adequately localized by using a skin marker if the lesion lies fairly superficially within the breast.[2] In addition, a surgeon can easily perform ultrasonographic localization in the operating room to identify the lesion and to confirm its adequate removal.[3, 4]

Other localization techniques include magnetic resonance imaging (MRI) and mammography (by using a grid, a holey plate, or a stereotactic method) (see the images below).[5, 6] Although a number of techniques are used to localize nonpalpable breast lesions, needle localization is the most common.[7, 8, 9]

Mammogram shows a spiculated mass to be transfixed Mammogram shows a spiculated mass to be transfixed by the guidewire.
Grid technique of localization. Grid technique of localization.

After successful placement of a guidewire, the patient is then taken to the operating room, where the surgeon commonly makes an incision at the site of the wire insertion and excises the wire and the lesion (see the following images). Some surgeons place a stiff outer cannula along the wire down to the wire tip and excise the tip along with the lesion.

Orthogonal (mediolateral) projection confirms the Orthogonal (mediolateral) projection confirms the position of the needle to be placed beyond the cluster of microcalcification.
Specimen radiograph shows the wire and the localiz Specimen radiograph shows the wire and the localized speculated mass in situ, with a good excision margin.

Impalpable lesions may also be marked by using an injection of methylene blue,[10, 11] charcoal suspension,[12] or radioisotopes.[13]

It is essential to obtain a diagnosis with a core biopsy under ultrasonographic or stereotactic guidance before surgery so that a definitive, 1-step surgical procedure can be planned. Once malignancy is diagnosed, any of the following procedures can be used to localize the lesion:

  • Skin-marker localization
  • Needle localization under ultrasonographic guidance
  • Needle localization under stereotactic guidance [6]
  • Radionuclide localization combined with sentinel-node biopsy [11]
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Radiographic Localization

Techniques that involve mammography usually require the upright mammographic attachment on a normal mammographic unit, although localizations with stereotactic prone tables also have been described. Before stereotaxy came into use, a grid (see the image below) or holey plate was used to calculate the position of needle placement in the X and Y planes.

Grid technique of localization. Grid technique of localization.

The depth was calculated from the lateromedial projection. The position was then checked according to the superimposition of target, hub, and shaft of the needle, and the required depth was verified on the orthogonal view (see the following image).

Orthogonal (mediolateral) projection confirms the Orthogonal (mediolateral) projection confirms the position of the needle to be placed beyond the cluster of microcalcification.

Stereotaxy enables the exact position to be located. The needle is then placed 1 cm beyond the lesion to ensure that it is adequately transfixed. Because of the accordion effect (the thickness of the breast expands when compression is released), the needle tip may migrate, causing the needle to be placed short of the lesion.[14] The final depth of the needle is therefore checked on the orthogonal view to ensure that the lesion is adequately transfixed.

Different needles exist, and most are introduced by using a stiffer, coaxial needle. Some needles are then removed, leaving the wire in situ. The wires commonly have a barb or hook that is deployed in the final position to anchor the wire in place. Some needles require the outer cannula to be retained in situ (see the image below). The choice of needles and wires used are dictated by the preference of the radiologist and the surgeons.

Image shows the specimen radiograph with a stellat Image shows the specimen radiograph with a stellate lesion containing clustered, pleomorphic microcalcification with wire in situ. Note the use of a stiff outer cannula.

After surgical removal of the lesion, specimen radiography must be performed to ensure that the lesion was adequately excised (see the following image).

Specimen radiograph shows the wire and the localiz Specimen radiograph shows the wire and the localized speculated mass in situ, with a good excision margin.
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Magnetic Resonance Imaging Localization

The use of magnetic resonance imaging (MRI) localization reflects the increasing use of magnetic resonance mammography. Although a portion of MRI-depicted lesions can subsequently be localized with ultrasonography, some of them are mammographically and ultrasonographically occult, which means that they require MRI-guided needle biopsy or localization.[5, 15]

All of the major manufacturers of MRI units have made biopsy attachments available; these require the patient to be kept in a semiprone position. MRI is then performed with the intravenous administration of a gadolinium-based contrast agent, and the lesion is localized by using MRI-compatible localization needles. The correct placement of the needle can be confirmed by obtaining a T2-weighted MRI to verify the signal void to transfix the lesion.

Technical challenges

Technical difficulties and challenges include the tendency of the MRI-visible lesion to fade over time (because enhancement with contrast material is transient).[5] In addition, because of the amount of time required to perform the procedure (30-60 min), the patient may begin to move, which could cause an error in needle placement. Nevertheless, MRI localizations have generally been as accurate as mammographic localizations, with miss rates of 2-9%. Some investigators have suggested that postoperative MRI should be performed to verify complete excision of the lesion.

Gadolinium warning

Gadolinium-based contrast agents (gadopentetate dimeglumine [Magnevist], gadobenate dimeglumine [MultiHance], gadodiamide [Omniscan], gadoversetamide [OptiMARK], gadoteridol [ProHance]) have been linked to the development of nephrogenic systemic fibrosis (NSF) or nephrogenic fibrosing dermopathy (NFD). The disease has occurred in patients with moderate to end-stage renal disease after being given a gadolinium-based contrast agent to enhance MRI or magnetic resonance angiography (MRA) scans.

NSF/NFD is a debilitating and sometimes fatal disease. Characteristics include red or dark patches on the skin; burning, itching, swelling, hardening, and tightening of the skin; yellow spots on the whites of the eyes; joint stiffness with trouble moving or straightening the arms, hands, legs, or feet; pain deep in the hip bones or ribs; and muscle weakness.

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Ultrasonographic Localization

When the breast lesion is visible, ultrasonography is the modality of choice for needle placement (see the following image). This technique provides the advantage of real-time imaging, allowing accurate placement of the needle. Being able to directly visualize the lesion and needle position results in a quicker procedure, reducing the risk of patient morbidity. As in mammographic techniques, the lesion must be transfixed, and orthogonal mammography can be used to confirm that the correct lesion has been localized.

Figure shows a poorly attenuating lesion being tra Figure shows a poorly attenuating lesion being transfixed with a hook wire under ultrasonographic guidance.

The use of intraoperative ultrasonography by the surgeon in the operating theater, as well as the employment of skin marking, is described in the Imaging and Localization Considerations section, above.

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Nuclear Medicine Localization

Nuclear medicine study was originally used for sentinel lymph node biopsy (SLNB). Colloidal albumin labeled with technetium-99m (99m Tc) is injected directly into the lesion under stereotactic or ultrasonographic guidance.[13]

The accuracy of isotope placement is checked with scintigraphy. Excision biopsy is then performed by using a gamma probe. After excision, the excised lesion and the cavity are checked for radioactivity, and the specimen is radiographed to ensure the radiographic adequacy of the excision. Results from a study of 67 consecutive patients showed complete removal of the lesion in 99.5% of them.[16] Thus, this technique is accurate and at least comparable to conventional wire localization.

Radiation exposure

Measured radioactive doses to the breast (0.03 ± 0.02 mGy/MBq) and to the surgeon's hand (7.5 ± 5.0 µSv/h) appear to be negligible.[16]

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Tissue Excision

The amount of tissue that is excised is dependent on the nature of the surgical procedure. If a diagnostic procedure is performed, a small volume of tissue is removed so that histologic diagnosis can be achieved with minimal scarring. When surgery is performed to treat malignant disease, the aim is to excise the lesion with a clear margin in order to minimize the risk of local recurrence.[13]

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Complications

All localization methods are subject to potential inaccuracies.[14] It is important to confirm the correct placement of the guidewire. Ultrasonographic and mammographic wire localizations can be followed by mammography performed in 2 planes (eg, lateromedial and craniocaudal projections) to confirm that the correct lesion has been accurately targeted.

Ideally, the guidewire should transfix the lesion on both projections (see the image below). The tip of the guidewire should ideally be placed within 1 cm of the target lesion.

Mammogram shows a spiculated mass to be transfixed Mammogram shows a spiculated mass to be transfixed by the guidewire.

Guidewires may be dislodged or may migrate before surgery. Complications, including pneumothoraces, have been described. Wire fragments may also be retained following surgery. Published literature show that the rate of needle-localization failure is in the range of 0-20%. Factors associated with such failure include the following[17, 18, 19] :

  • Lesion type
  • Lesion size
  • Increased distance of the needle from the lesion
  • Decreased breast size
  • Decreased specimen volume
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Contributor Information and Disclosures
Author

William Teh, MBChB, FRCR Lead Cancer Clinician, Department of Radiology, Northwick Park Hospital; Director of Screening, North London Breast Screening Service, UK

William Teh, MBChB, FRCR is a member of the following medical societies: British Institute of Radiology, British Medical Association, Royal College of Radiologists

Disclosure: Received honoraria from Hologic for speaking and teaching.

Coauthor(s)

Hemant Singhal, MD, MBBS, FRCS(Edin), FRCSC Consultant Surgeon, Clementine Churchill Hospital; Director of Breast Service, Medanta The Medicity; Senior Lecturer, Department of Surgery, Imperial College School of Medicine

Hemant Singhal, MD, MBBS, FRCS(Edin), FRCSC is a member of the following medical societies: Royal College of Physicians and Surgeons of Canada, Royal College of Surgeons of Edinburgh

Disclosure: Nothing to disclose.

Specialty Editor Board

Edward Azavedo, MD, PhD Director of Clinical Breast Imaging Services, Associate Professor, Department of Radiology, Karolinska University Hospital, Sweden

Edward Azavedo, MD, PhD is a member of the following medical societies: Radiological Society of North America, Swedish Medical Association, Swedish Society of Medicine

Disclosure: Nothing to disclose.

Additional Contributors

John M Lewin, MD Section Chief, Breast Imaging, Diversified Radiology of Colorado, PC; Associate Clinical Professor, Department of Preventative Medicine and Biometrics, University of Colorado School of Medicine

John M Lewin, MD is a member of the following medical societies: American College of Radiology, American Roentgen Ray Society, Radiological Society of North America, Society of Breast Imaging

Disclosure: Received consulting fee from Hologic, Inc. for consulting; Received grant/research funds from Hologic, Inc. for research.

References
  1. Guidelines for surgeons in the management of symptomatic breast disease in the United Kingdom. Eur J Surg Oncol. 1995 Oct. 21 Suppl A:1-13. [Medline].

  2. Wilson M, Boggis CR, Mansel RE, Harland RN. Non-invasive ultrasound localization of impalpable breast lesions. Clin Radiol. 1993 May. 47(5):337-8. [Medline].

  3. Fornage BD, Ross MI, Singletary SE, Paulus DD. Localization of impalpable breast masses: value of sonography in the operating room and scanning of excised specimens. AJR Am J Roentgenol. 1994 Sep. 163(3):569-73. [Medline]. [Full Text].

  4. Fortunato L, Penteriani R, Farina M, Vitelli CE, Piro FR. Intraoperative ultrasound is an effective and preferable technique to localize non-palpable breast tumors. Eur J Surg Oncol. 2008 Dec. 34(12):1289-92. [Medline].

  5. Morris EA, Liberman L, Dershaw DD, et al. Preoperative MR imaging-guided needle localization of breast lesions. AJR Am J Roentgenol. 2002 May. 178(5):1211-20. [Medline]. [Full Text].

  6. Welch BL, Brem R, Black R, Majewski S. Quality assurance procedure for a gamma guided stereotactic breast biopsy system. Phys Med. 2006. 21 Suppl 1:102-5. [Medline].

  7. Silverstein MJ, Gamagami P, Rosser RJ, et al. Hooked-wire-directed breast biopsy and overpenetrated mammography. Cancer. 1987 Feb 15. 59(4):715-22. [Medline].

  8. Lannin DR, Grube B, Black DS, Ponn T. Breast tattoos for planning surgery following neoadjuvant chemotherapy. Am J Surg. 2007 Oct. 194(4):518-20. [Medline].

  9. Haid A, Knauer M, Dunzinger S, et al. Intra-operative sonography: a valuable aid during breast-conserving surgery for occult breast cancer. Ann Surg Oncol. 2007 Nov. 14(11):3090-101. [Medline].

  10. Zografos GC, Doumitriou C, Lappas D, et al. Localization of nonpalpable breast lesions using hook-wire combined with isosulfan blue dye. J Surg Oncol. 2003 Jan. 82(1):73-4. [Medline].

  11. Varghese P, Abdel-Rahman AT, Akberali S, Mostafa A, Gattuso JM, Carpenter R. Methylene blue dye--a safe and effective alternative for sentinel lymph node localization. Breast J. 2008 Jan-Feb. 14(1):61-7. [Medline].

  12. Canavese G, Catturich A, Vecchio C, et al. Pre-operative localization of non-palpable lesions in breast cancer by charcoal suspension. Eur J Surg Oncol. 1995 Feb. 21(1):47-9. [Medline].

  13. Luini A, Zurrida S, Paganelli G, et al. Comparison of radioguided excision with wire localization of occult breast lesions. Br J Surg. 1999 Apr. 86(4):522-5. [Medline].

  14. Guenin MA. Stereotactic needle localization. AJR Am J Roentgenol. 2001 Jan. 176(1):254-5. [Medline]. [Full Text].

  15. van den Bosch MA, Daniel BL, Pal S, Nowels KW, Birdwell RL, Jeffrey SS, et al. MRI-guided needle localization of suspicious breast lesions: results of a freehand technique. Eur Radiol. 2006 Aug. 16(8):1811-7. [Medline].

  16. Gennari R, Galimberti V, De Cicco C, Zurrida S, Zerwes F, Pigatto F, et al. Use of technetium-99m-labeled colloid albumin for preoperative and intraoperative localization of nonpalpable breast lesions. J Am Coll Surg. 2000 Jun. 190(6):692-8; discussion 698-9. [Medline].

  17. Jackman RJ, Marzoni FA Jr. Needle-localized breast biopsy: why do we fail?. Radiology. 1997 Sep. 204(3):677-84. [Medline]. [Full Text].

  18. Abrahamson PE, Dunlap LA, Amamoo MA, Schell MJ, Braeuning MP, Pisano ED. Factors predicting successful needle-localized breast biopsy. Acad Radiol. 2003 Jun. 10(6):601-6. [Medline].

  19. Kouskos E, Gui GP, Mantas D, Revenas K, Rallis N, Antonopoulou Z, et al. Wire localisation biopsy of non-palpable breast lesions: reasons for unsuccessful excision. Eur J Gynaecol Oncol. 2006. 27(3):262-6. [Medline].

  20. Landercasper J, Attai D, Atisha D, et al. Toolbox to reduce lumpectomy reoperations and improve cosmetic outcome in breast cancer patients: The American Society of Breast Surgeons Consensus Conference. Ann Surg Oncol. 2015 Oct. 22(10):3174-83. [Medline].

  21. Plecha D, Bai S, Patterson H, Thompson C, Shenk R. Improving the accuracy of axillary lymph node surgery in breast cancer with ultrasound-guided wire localization of biopsy proven metastatic lymph nodes. Ann Surg Oncol. 2015 Dec. 22(13):4241-6. [Medline].

 
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Mammogram shows a spiculated mass to be transfixed by the guidewire.
Grid technique of localization.
Orthogonal (mediolateral) projection confirms the position of the needle to be placed beyond the cluster of microcalcification.
Specimen radiograph shows the wire and the localized speculated mass in situ, with a good excision margin.
Figure shows a poorly attenuating lesion being transfixed with a hook wire under ultrasonographic guidance.
Image shows the specimen radiograph with a stellate lesion containing clustered, pleomorphic microcalcification with wire in situ. Note the use of a stiff outer cannula.
 
 
 
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