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Plummer-Vinson Syndrome Medication

  • Author: Louis-Michel Wong Kee Song, MD; Chief Editor: BS Anand, MD  more...
 
Updated: Aug 20, 2015
 

Medication Summary

The goals of pharmacotherapy are to reduce morbidity and to prevent complications.

Ferrous preparations are administered to correct the deficiency in iron (with or without anemia) in patients with Plummer-Vinson syndrome (PVS).

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Iron preparations

Class Summary

Iron replacement is an important component of the treatment of PVS.[23]

Ferrous sulfate (Feosol)

 

A nutritionally essential inorganic substance used to treat iron deficiency anemia associated with PVS.

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Contributor Information and Disclosures
Author

Louis-Michel Wong Kee Song, MD Associate Professor, Department of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic

Louis-Michel Wong Kee Song, MD is a member of the following medical societies: American College of Gastroenterology, American Gastroenterological Association, American Society for Gastrointestinal Endoscopy

Disclosure: Nothing to disclose.

Specialty Editor Board

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Noel Williams, MD, FRCPC FACP, MACG, Professor Emeritus, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada; Professor, Department of Internal Medicine, Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada

Noel Williams, MD, FRCPC is a member of the following medical societies: Royal College of Physicians and Surgeons of Canada

Disclosure: Nothing to disclose.

Chief Editor

BS Anand, MD Professor, Department of Internal Medicine, Division of Gastroenterology, Baylor College of Medicine

BS Anand, MD is a member of the following medical societies: American Association for the Study of Liver Diseases, American College of Gastroenterology, American Gastroenterological Association, American Society for Gastrointestinal Endoscopy

Disclosure: Nothing to disclose.

Additional Contributors

Marco G Patti, MD Professor of Surgery, Director, Center for Esophageal Diseases, University of Chicago Pritzker School of Medicine

Marco G Patti, MD is a member of the following medical societies: American Association for the Advancement of Science, American Surgical Association, American College of Surgeons, American Gastroenterological Association, American Medical Association, Association for Academic Surgery, Pan-Pacific Surgical Association, Society for Surgery of the Alimentary Tract, Society of American Gastrointestinal and Endoscopic Surgeons, Southwestern Surgical Congress, Western Surgical Association

Disclosure: Nothing to disclose.

References
  1. Atmatzidis K, Papaziogas B, Pavlidis T, Mirelis Ch, Papaziogas T. Plummer-Vinson syndrome. Dis Esophagus. 2003. 16(2):154-7. [Medline].

  2. Chisholm M. The association between webs, iron and post-cricoid carcinoma. Postgrad Med J. 1974 Apr. 50(582):215-9. [Medline].

  3. Hoffman RM, Jaffe PE. Plummer-Vinson syndrome. A case report and literature review. Arch Intern Med. 1995 Oct 9. 155(18):2008-11. [Medline].

  4. Jacobs A, Kilpatrick GS. The Paterson-Kelly syndrome. Br Med J. 1964 Jul 11. 2 (5401):79-82. [Medline].

  5. Slater SD. The Brown Kelly-Paterson or Plummer-Vinson syndrome: an old score finally settled. J R Coll Physicians Lond. 1991 Jul. 25(3):257-8. [Medline].

  6. Waldenstrom J, Kjellberg SR. The roentgenological diagnosis of sideropenic dysphagia (Plummer-Vinson's syndrome). Acta Radiol. 1939. 20:618-38.

  7. Elwood PC, Jacobs A, Pitman RG, Entwistle CC. Epidemiology of the Paterson-Kelly syndrome. Lancet. 1964 Oct 3. 2 (7362):716-20. [Medline].

  8. Geerlings SE, Statius van Eps LW. Pathogenesis and consequences of Plummer-Vinson syndrome. Clin Investig. 1992 Aug. 70(8):629-30. [Medline].

  9. Dantas RO, Villanova MG. Esophageal motility impairment in Plummer-Vinson syndrome. Correction by iron treatment. Dig Dis Sci. 1993 May. 38(5):968-71. [Medline].

  10. Dickey W, McConnell B. Celiac disease presenting as the Paterson-Brown Kelly (Plummer-Vinson) syndrome. Am J Gastroenterol. 1999 Feb. 94(2):527-9. [Medline].

  11. Buse PE, Zuckerman GR, Balfe DM. Cervical esophageal web associated with a patch of heterotopic gastric mucosa. Abdom Imaging. 1993. 18(3):227-8. [Medline].

  12. Jerome-Zapadka KM, Clarke MR, Sekas G. Recurrent upper esophageal webs in association with heterotopic gastric mucosa: case report and literature review. Am J Gastroenterol. 1994 Mar. 89(3):421-4. [Medline].

  13. Ekberg O, Nylander G. Webs and web-like formations in the pharynx and cervical esophagus. Diagn Imaging. 1983. 52(1):10-8. [Medline].

  14. Maleki D, Cameron AJ. Plummer-Vinson syndrome associated with chronic blood loss anemia and large diaphragmatic hernia. Am J Gastroenterol. 2002 Jan. 97(1):190-3. [Medline].

  15. Chen TS, Chen PS. Rise and fall of the Plummer-Vinson syndrome. J Gastroenterol Hepatol. 1994 Nov-Dec. 9(6):654-8. [Medline].

  16. Mansell NJ, Jani P, Bailey CM. Plummer-Vinson syndrome--a rare presentation in a child. J Laryngol Otol. 1999 May. 113(5):475-6. [Medline].

  17. Jessner W, Vogelsang H, Puspok A, et al. Plummer-Vinson syndrome associated with celiac disease and complicated by postcricoid carcinoma and carcinoma of the tongue. Am J Gastroenterol. 2003 May. 98(5):1208-9. [Medline].

  18. Nosher JL, Campbel WL, Seaman WB. The clinical significance of cervical esophageal and hypopharyngeal webs. Radiology. 1975 Oct. 117(1):45-7. [Medline].

  19. Larsson LG, Sandstrom A, Westling P. Relationship of Plummer-Vinson disease to cancer of the upper alimentary tract in Sweden. Cancer Res. 1975 Nov. 35(11 pt 2):3308-16. [Medline].

  20. Rashid Z, Kumar A, Komar M. Plummer-Vinson syndrome and postcricoid carcinoma: late complications of unrecognized celiac disease. Am J Gastroenterol. 1999 Jul. 94(7):1991. [Medline].

  21. Paterson DR. A clinical type of dysphagia. J Laryngol Rhinol Otol. 1919. 34:289-91.

  22. Hoover WB. The syndrome of anemia, glossitis, and dysphagia. New Engl J Med. 1935. 213(9):394-8.

  23. Bredenkamp JK, Castro DJ, Mickel RA. Importance of iron repletion in the management of Plummer-Vinson syndrome. Ann Otol Rhinol Laryngol. 1990 Jan. 99(1):51-4. [Medline].

  24. Huynh PT, de Lange EE, Shaffer HA Jr. Symptomatic webs of the upper esophagus: treatment with fluoroscopically guided balloon dilation. Radiology. 1995 Sep. 196(3):789-92. [Medline].

  25. Lindgren S. Endoscopic dilatation and surgical myectomy of symptomatic cervical esophageal webs. Dysphagia. 1991. 6(4):235-8. [Medline].

  26. Krevsky B, Pusateri JP Jr. Laser lysis of an esophageal web. Gastrointest Endosc. 1989 Sep-Oct. 35(5):451-3. [Medline].

  27. Seo MH, Chun HJ, Jeen YT, et al. Esophageal web resolved by endoscopic incision in a patient with Plummer-Vinson syndrome. Gastrointest Endosc. 2011 Nov. 74(5):1142-3. [Medline].

  28. Brown Kelly A. Spasm at the entrance of the oesophagus. J Laryngol Rhinol Otol. 1919. 34:285-9.

  29. Okamura H, Tsutsumi S, Inaki S, Mori T. Esophageal web in Plummer-Vinson syndrome. Laryngoscope. 1988 Sep. 98(9):994-8. [Medline].

  30. Vinson PP. Hysterical dysphagia. Minn Med. 1922. 5:107-8.

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Postcricoid web. Courtesy of Alan Cameron, MD.
Upper esophageal web.
Upper esophageal web.
 
 
 
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