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Mesenteric Tumors Treatment & Management

  • Author: Neal E Seymour, MD; Chief Editor: John Geibel, MD, DSc, MSc, MA  more...
Updated: Jun 16, 2016

Approach Considerations

The presence of any solid mass lesion of the mesentery that is not thought to be a reactive lymph node or lymphoma is an indication for surgical removal. The inability to definitively exclude malignancy makes prolonged observation and repetitive studies an ill-advised management strategy.

In selected circumstances, biopsy is indicated to help confirm the diagnosis of certain lesions. For example, lymphoma might represent a likely diagnosis on the basis of radiologic findings. If no other more readily accessible tissues were available, it would be necessary to obtain mesenteric tissue to guide therapy.

A small simple cyst of the mesentery discovered incidentally can be observed. In the setting of interval enlargement, significant symptoms (generally pain), or evolution of symptoms, surgical excision is advisable for simple cysts as well. Complex cystic structures related to the omentum must prompt consideration of the possibility of a neoplastic process.

The use of laparoscopic methods to investigate and treat mesenteric masses is an evolving area of surgical care. In patients whose disease must be distinguished only from that requiring resection (ie, lymphoma, mesenteric lipodystrophy), laparoscopy offers a method of obtaining tissue for diagnostic purposes without subjecting the patient to a full laparotomy incision.


Medical Therapy

In general, effective medical treatment for neoplastic mesenteric masses is not available. Pain and other gastrointestinal complaints can be treated with analgesics and antiemetics, but these agents do not affect the underlying disease.

Mesenteric lymphoma is treated by cytotoxic chemotherapy. Mesenteric desmoid tumors reportedly respond to sulindac therapy, hormonal manipulation, and cytotoxic chemotherapy.[6, 16]


Surgical Therapy

In general, surgical treatment of benign mesenteric masses consists of local excision for smaller lesions and resection for bulkier tumors, provided that the blood supply to the gut is not jeopardized. Although the bowel can be preserved in most circumstances, resection can be quite treacherous, depending on the relationship of the lesion to larger branches of the superior mesenteric artery. Most cystic mesenteric lesions can be easily excised. Resection of small intestine is rarely indicated for this problem.

Approaches to different tumor types

Malignant mesenteric tumors

Surgical treatment is the only therapy of demonstrated benefit for these tumors. The goal of surgical treatment is removal of gross disease with a margin of normal tissue. This requires resection of any involved intestine, as well as any intestine robbed of mesenteric arterial blood supply by the dissection to remove the tumor. As in the treatment of intestinal stromal tumors or retroperitoneal sarcomas, operative management may involve en-bloc resection of other involved structures.

Mesenteric desmoid tumors

These are very difficult lesions to treat surgically. Surgical treatment may increase recurrence risk, because it has been observed that desmoid tumors generally occur after abdominal surgery. Surgical debulking may be dangerous and ultimately unsuccessful and is generally reserved for patients with intestinal obstruction.[6, 7]

Mesenteric lymphoma

In contrast to primary small-bowel lymphoma, for which surgical treatment may play a valuable role in selected cases, mesenteric lymphoma is best treated with combination chemotherapy. Although some cases are diagnosed after resection of an uncharacterized mesenteric mass, surgical treatment is best used as a diagnostic tool when the diagnosis is probable but uncertain. Laparoscopy may play an important role when procurement of tissue for diagnostic purposes is the operative goal.

Mesenteric carcinoid tumor

This pattern of disease is treated by surgically resecting the mesenteric masses. This procedure should be performed en bloc with any extant primary intestinal tumor. Resection of mesenteric disease should be accomplished without endangering the blood supply to normal bowel, except in the immediate area of the disease. A primary carcinoid tumor, which may be quite small and multicentric, is generally found in the resected intestinal specimen.

Castleman disease

Because this problem is nonneoplastic and generally localized, treatment consisting of resection of the lymph node mass has had good results.

Operative details

At exploration, the mass is generally found to be completely contained within the mesentery. In the case of liposarcoma, encasement of the bowel with fatty tumor tissue can occur (see the image below). The gross extent of the tumor must be carefully defined in order to obtain clear margins of resection. Definition of proximity to large mesenteric blood vessels is vital. Normal intestine should be preserved to the greatest extent possible while still observing good oncologic surgical principles. If resection requires so much intestine to be removed that maintenance of nutrition cannot be expected, the patient's clinical situation (eg, age, general health) must be taken into consideration before proceeding.

Resected mesenteric liposarcoma specimen. This fir Resected mesenteric liposarcoma specimen. This firm, fatty mass replaced large-segment of small bowel mesentery and surrounded short segment of ileum (lower edge of specimen). Principal presenting problem was partial small-bowel obstruction.


Complications of surgical treatment of mesenteric masses are not specific to the disease type, except when extensive resection of solid tumors may endanger the mesenteric blood supply or when extensive small-bowel resection is necessary to remove the disease. Although short-bowel syndrome is an infrequent occurrence in surgery involving the mesentery, appropriate precautions must be taken to prevent this condition, which can result from overresection or from inadvertent damage to the blood supply to otherwise normal bowel.

Contributor Information and Disclosures

Neal E Seymour, MD Professor, Department of Surgery, Tufts University School of Medicine

Neal E Seymour, MD is a member of the following medical societies: Association for Surgical Education, Alpha Omega Alpha, Association of Program Directors in Surgery, American College of Surgeons, Association for Academic Surgery, Society for Surgery of the Alimentary Tract, Society of American Gastrointestinal and Endoscopic Surgeons, Society of University Surgeons

Disclosure: Nothing to disclose.

Specialty Editor Board

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Amy L Friedman, MD Professor of Surgery, Director of Transplantation, State University of New York Upstate Medical University College of Medicine, Syracuse

Amy L Friedman, MD is a member of the following medical societies: Association for Academic Surgery, International College of Surgeons, New York Academy of Sciences, Pennsylvania Medical Society, Philadelphia County Medical Society, Society of Critical Care Medicine, Association of Women Surgeons, International Liver Transplantation Society, Transplantation Society, American College of Surgeons, American Medical Association, American Medical Womens Association, American Society for Artificial Internal Organs, American Society of Transplant Surgeons, American Society of Transplantation

Disclosure: Nothing to disclose.

Chief Editor

John Geibel, MD, DSc, MSc, MA Vice Chair and Professor, Department of Surgery, Section of Gastrointestinal Medicine, and Department of Cellular and Molecular Physiology, Yale University School of Medicine; Director, Surgical Research, Department of Surgery, Yale-New Haven Hospital; American Gastroenterological Association Fellow

John Geibel, MD, DSc, MSc, MA is a member of the following medical societies: American Gastroenterological Association, American Physiological Society, American Society of Nephrology, Association for Academic Surgery, International Society of Nephrology, New York Academy of Sciences, Society for Surgery of the Alimentary Tract

Disclosure: Received royalty from AMGEN for consulting; Received ownership interest from Ardelyx for consulting.

  1. Gonzalez-Crussi F, deMello DE, Sotelo-Avila C. Omental-mesenteric myxoid hamartomas. Infantile lesions simulating malignant tumors. Am J Surg Pathol. 1983 Sep. 7(6):567-78. [Medline].

  2. Goh BK, Chow PK, Kesavan SM, et al. A single-institution experience with eight CD117-positive primary extragastrointestinal stromal tumors: critical appraisal and a comparison with their gastrointestinal counterparts. J Gastrointest Surg. 2009 Jun. 13(6):1094-8. [Medline].

  3. Sidhic AK, Ranjith M, Ali KP, Tej PR. Leiomyosarcoma of the mesentry, a rare mesentric tumour. Int J Surg Case Rep. 2015. 7C:58-60. [Medline].

  4. Varghese M, Bruland O, Wiedswang AM, Lobmaier I, Røsok B, Benjamin RS, et al. Metastatic mesenteric dedifferentiated leiomyosarcoma: a case report and a review of literature. Clin Sarcoma Res. 2016. 6:2. [Medline].

  5. Miettinen M, Monihan JM, Sarlomo-Rikala M. Gastrointestinal stromal tumors/smooth muscle tumors (GISTs) primary in the omentum and mesentery: clinicopathologic and immunohistochemical study of 26 cases. Am J Surg Pathol. 1999 Sep. 23(9):1109-18. [Medline].

  6. Seow-Choen F. The management of desmoids in patients with familial adenomatous polyposis (FAP). Acta Chir Iugosl. 2008. 55(3):83-7. [Medline].

  7. Clark SK, Phillips RK. Desmoids in familial adenomatous polyposis. Br J Surg. 1996 Nov. 83(11):1494-504. [Medline].

  8. Caspari R, Olschwang S, Friedl W. Familial adenomatous polyposis: desmoid tumours and lack of ophthalmic lesions (CHRPE) associated with APC mutations beyond codon 1444. Hum Mol Genet. 1995 Mar. 4(3):337-40. [Medline].

  9. van Krieken JH, Otter R, Hermans J. Malignant lymphoma of the gastrointestinal tract and mesentery. A clinico-pathologic study of the significance of histologic classification. NHL Study Group of the Comprehensive Cancer Center West. Am J Pathol. 1989 Aug. 135(2):281-9. [Medline]. [Full Text].

  10. Metaxas G, Tangalos A, Pappa P, et al. Mucinous cystic neoplasms of the mesentery: a case report and review of the literature. World J Surg Oncol. 2009 May 19. 7:47. [Medline]. [Full Text].

  11. Guivarc'h M. [Tumors of the mesentery. Apropos of 102 cases]. Ann Chir. 1994. 48 (1):7-16. [Medline].

  12. Luo HS. [Mesentery tumor--clinico-pathologic analysis of 171 cases]. Chung Hua Chung Liu Tsa Chih. 1989 Mar. 11(2):139-41. [Medline].

  13. Cook MB, Dawsey SM, Freedman ND, et al. Sex disparities in cancer incidence by period and age. Cancer Epidemiol Biomarkers Prev. 2009 Apr. 18(4):1174-82. [Medline]. [Full Text].

  14. Velasco S, Milin S, Maurel C, et al. Scanographic features of gastrointestinal stromal tumors. Gastroenterol Clin Biol. 2008 Dec. 32(12):1001-13. [Medline]. [Full Text].

  15. Amzallag-Bellenger E, Soyer P, Barbe C, Nguyen TL, Amara N, Hoeffel C. Diffusion-weighted imaging for the detection of mesenteric small bowel tumours with Magnetic Resonance--enterography. Eur Radiol. 2014 Aug 12. [Medline].

  16. Quast DR, Schneider R, Burdzik E, Hoppe S, Möslein G. Long-term outcome of sporadic and FAP-associated desmoid tumors treated with high-dose selective estrogen receptor modulators and sulindac: a single-center long-term observational study in 134 patients. Fam Cancer. 2016 Jan. 15 (1):31-40. [Medline].

This small, well-circumscribed lesion of small-bowel mesentery caused no symptoms and was incidentally discovered at operation.
Computed tomography (CT) scan of mesenteric stromal tumor (circled area). Shown is infiltrative lesion surrounding vascular structures within proximal jejunal mesentery.
Resected mesenteric liposarcoma specimen. This firm, fatty mass replaced large-segment of small bowel mesentery and surrounded short segment of ileum (lower edge of specimen). Principal presenting problem was partial small-bowel obstruction.
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