Pancreatic Pseudoaneurysm Workup

  • Author: Faisal Aziz; Chief Editor: John Geibel, MD, DSc, MA   more...
 
Updated: Nov 29, 2011
 

Imaging Studies

  • Angiography
    • Angiography is the criterion standard to determine diagnosis and treatment (see image below). Digital subtraction provides high-resolution imaging of small arteries and allows percutaneous vascular intervention in the same setting.[6] Splenic artery angiogram demonstrating contrast (wSplenic artery angiogram demonstrating contrast (white arrow) extravasating into a pseudoaneurysm (black arrow).
    • If the patient is hemodynamically stable, performing a preoperative angiogram helps confirm the diagnosis. Angiography defines the character—unique or otherwise—of the lesion and allows therapeutic planning. Angiography greatly facilitates identification of the location and serves as a topographical guide for the pseudoaneurysm, which aids in operative proximal and distal control of the bleeding vessel.
    • Preoperative angiography might constitute an opportunity to gain temporary control over the bleeding vessel by performing transcatheter embolization, thus providing a time window for the surgeon to operate on a high-risk patient under optimum clinical conditions.
  • CT angiography has a sensitivity of up to 94.7% and a specificity of 90% (see image below).[7] A CT scan with intravenous contrast enhancement (aA CT scan with intravenous contrast enhancement (arrow) within a pancreatic pseudocyst indicating the presence of a pseudoaneurysm.
  • Magnetic resonance (MR) angiography is highly sensitive and specific. Limitations of MR angiography include its long study time, availability, high cost, and restrictions for patients with certain implantable devices and hardware.
 
 
Contributor Information and Disclosures
Author

Faisal Aziz  MD, Assistant Professor of Surgery, Division of Vascular & Endovascular Surgery, Department of Surgery, Penn State University College of Medicine, Hershey, PA

Faisal Aziz is a member of the following medical societies: American College of Surgeons and American Medical Association

Disclosure: Nothing to disclose.

Coauthor(s)

John A Savino, MD  Professor of Surgery, Chairman, Director of Residency Program, Department of Surgery, New York Medical College; Director of Surgical Critical Care Fellowship, Director of Surgical Intensive Care Unit, Attending Surgeon, Westchester Medical Center

John A Savino, MD is a member of the following medical societies: American Association for the Surgery of Trauma, American College of Surgeons, American Medical Association, Association for Academic Surgery, Association for Surgical Education, Eastern Association for the Surgery of Trauma, Medical Society of the State of New York, Society for Surgery of the Alimentary Tract, Society of American Gastrointestinal and Endoscopic Surgeons, Society of Critical Care Medicine, and Surgical Infection Society

Disclosure: Nothing to disclose.

Mazen S Itani, MD, FACS  Private Practice in Vascular Surgery, Hackettstown Regional Medical Center

Mazen S Itani, MD, FACS is a member of the following medical societies: American Medical Association

Disclosure: Nothing to disclose.

Nabil Sumrani, MD  Associate Professor, Department of Surgery, Division of Transplantation Surgery, State University of New York Health Science Center at Brooklyn

Nabil Sumrani, MD is a member of the following medical societies: Central Surgical Association

Disclosure: Nothing to disclose.

Specialty Editor Board

Alex Jacocks, MD  Program Director, Professor, Department of Surgery, University of Oklahoma School of Medicine

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD  Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Salary Employment

Michael A Grosso, MD  Consulting Staff, Department of Cardiothoracic Surgery, St Francis Hospital

Michael A Grosso, MD is a member of the following medical societies: American College of Surgeons, Society of Thoracic Surgeons, and Society of University Surgeons

Disclosure: Nothing to disclose.

Paolo Zamboni, MD  Professor of Surgery, Chief of Day Surgery Unit, Chair of Vascular Diseases Center, University of Ferrara, Italy

Paolo Zamboni, MD is a member of the following medical societies: American Venous Forum and New York Academy of Sciences

Disclosure: Nothing to disclose.

Chief Editor

John Geibel, MD, DSc, MA  Vice Chair and Professor, Department of Surgery, Section of Gastrointestinal Medicine, and Department of Cellular and Molecular Physiology, Yale University School of Medicine; Director, Surgical Research, Department of Surgery, Yale-New Haven Hospital

John Geibel, MD, DSc, MA is a member of the following medical societies: American Gastroenterological Association, American Physiological Society, American Society of Nephrology, Association for Academic Surgery, International Society of Nephrology, New York Academy of Sciences, and Society for Surgery of the Alimentary Tract

Disclosure: AMGEN Royalty Consulting; ARdelyx Ownership interest Board membership

References
  1. Shrikhande GV, Khan SZ, Gallagher K, Morrissey NJ. Endovascular management of superior mesenteric artery pseudoaneurysm. J Vasc Surg. Jan 2011;53(1):209-11. [Medline].

  2. James CA, Emanuel PG, Vasquez WD, et al. Embolization of splenic artery branch pseudoaneurysm after blunt abdominal trauma. J Trauma. May 1996;40(5):835-7. [Medline].

  3. Harvey J, Dardik H, Impeduglia T, et al. Endovascular management of hepatic artery pseudoaneurysm hemorrhage complicating pancreaticoduodenectomy. J Vasc Surg. Mar 2006;43(3):613-7. [Medline].

  4. Radeleff B, Noeldge G, Heye T, et al. Pseudoaneurysms of the common hepatic artery following pancreaticoduodenectomy: successful emergency embolization. Cardiovasc Intervent Radiol. Jan-Feb 2007;30(1):129-32. [Medline].

  5. Tessier DJ, Stone WM, Fowl RJ, et al. Clinical features and management of splenic artery pseudoaneurysm: case series and cumulative review of literature. J Vasc Surg. Nov 2003;38(5):969-74. [Medline].

  6. Pilleul F, Beuf O. Diagnosis of splanchnic artery aneurysms and pseudoaneurysms, with special reference to contrast enhanced 3D magnetic resonance angiography: a review. Acta Radiol. Nov 2004;45(7):702-8. [Medline].

  7. Hyare H, Desigan S, Nicholl H, et al. Multi-section CT angiography compared with digital subtraction angiography in diagnosing major arterial hemorrhage in inflammatory pancreatic disease. Eur J Radiol. Aug 2006;59(2):295-300. [Medline].

  8. Szopinski P, Ciostek P, Pleban E, et al. Percutaneous thrombin injection to complete SMA pseudoaneurysm exclusion after failing of endograft placement. Cardiovasc Intervent Radiol. Jul-Aug 2005;28(4):509-14. [Medline].

  9. Krueger K, Zaehringer M, Lackner K. Percutaneous treatment of a splenic artery pseudoaneurysm by thrombin injection. J Vasc Interv Radiol. Jul 2005;16(7):1023-5. [Medline].

  10. Kennedy RD, Clapp AJ, Potter DD, McKusick MA, Petersen BT, Friese JL. Percutaneous ultrasound-guided thrombin injection of a post-traumatic pancreatic pseudoaneurysm in a pediatric patient. Pediatr Surg Int. Oct 4 2011;[Medline].

  11. Patel JV, Weston MJ, Kessel DO, et al. Hepatic artery pseudoaneurysm after liver transplantation: treatment with percutaneous thrombin injection. Transplantation. May 27 2003;75(10):1755-57. [Medline].

  12. Bender JS, Levison MA. Massive hemorrhage associated with pancreatic pseudocyst: successful treatment by pancreaticoduodenectomy. Am Surg. Oct 1991;57(10):653-5. [Medline].

  13. Bender JS, Bouwman DL, Levison MA, et al. Pseudocysts and pseudoaneurysms: surgical strategy. Pancreas. Mar 1995;10(2):143-7. [Medline].

  14. Luchs SG, Antonacci VP, Reid SK, et al. Vascular and interventional case of the day. Pancreatic head pseudoaneurysm treated with percutaneous thrombin injection. AJR Am J Roentgenol. Sep 1999;173(3):830, 833-4. [Medline].

  15. Boudghene F, L'Hermine C, Bigot JM. Arterial complications of pancreatitis: diagnostic and therapeutic aspects in 104 cases. J Vasc Interv Radiol. Jul-Aug 1993;4(4):551-8. [Medline].

  16. Bradley EL, Clements JL Jr, Gonzalez AC. The natural history of pancreatic pseudocysts: a unified concept of management. Am J Surg. Jan 1979;137(1):135-41. [Medline].

  17. Bresler L, Boissel P, Grosdidier J. Major hemorrhage from pseudocysts and pseudoaneurysms caused by chronic pancreatitis: surgical therapy. World J Surg. Sep-Oct 1991;15(5):649-52; discussion 652-3. [Medline].

  18. Brodsky JT, Turnbull AD. Arterial hemorrhage after pancreatoduodenectomy. The 'sentinel bleed'. Arch Surg. Aug 1991;126(8):1037-40. [Medline].

  19. Cahow CE, Gusberg RJ, Gottlieb LJ. Gastrointestinal hemorrhage from pseudoaneurysms in pancreatic pseudocysts. Am J Surg. Apr 1983;145(4):534-41. [Medline].

  20. Clay RP, Farnell MB, Lancaster JR, et al. Hemosuccus pancreaticus. An unusual cause of upper gastrointestinal bleeding. Ann Surg. Jul 1985;202(1):75-9. [Medline].

  21. De Ronde T, Van Beers B, de Canniere L et al. Thrombosis of splenic artery pseudoaneurysm complicating pancreatitis. Gut. Sep 1993;34(9):1271-3. [Medline].

  22. Eckhauser FE, Stanley JC, Zelenock GB, et al. Gastroduodenal and pancreaticoduodenal artery aneurysms: a complication of pancreatitis causing spontaneous gastrointestinal hemorrhage. Surgery. Sep 1980;88(3):335-44. [Medline].

  23. El Hamel A, Parc R, Adda G, et al. Bleeding pseudocysts and pseudoaneurysms in chronic pancreatitis. Br J Surg. Sep 1991;78(9):1059-63. [Medline].

  24. Elton E, Howell DA, Amberson SM, et al. Combined angiographic and endoscopic management of bleeding pancreatic pseudoaneurysms. Gastrointest Endosc. Dec 1997;46(6):544-9. [Medline].

  25. Frey CF, Child CG, Fry W. Pancreatectomy for chronic pancreatitis. Ann Surg. Oct 1976;184(4):403-13. [Medline].

  26. Gadacz TR, Trunkey D, Kieffer RF Jr. Visceral vessel erosion associated with pancreatitis. Case reports and a review of the literature. Arch Surg. Dec 1978;113(12):1438-40. [Medline].

  27. Gambiez LP, Ernst OJ, Merlier OA, et al. Arterial embolization for bleeding pseudocysts complicating chronic pancreatitis. Arch Surg. Sep 1997;132(9):1016-21. [Medline].

  28. Hofer BO, Ryan JA Jr, Freeny PC. Surgical significance of vascular changes in chronic pancreatitis. Surg Gynecol Obstet. Jun 1987;164(6):499-505. [Medline].

  29. Huizinga WK, Kalideen JM, Bryer JV, et al. Control of major haemorrhage associated with pancreatic pseudocysts by transcatheter arterial embolization. Br J Surg. Feb 1984;71(2):133-6. [Medline].

  30. Khan TF, Ciancio G, Burke GW 3rd, et al. Pseudoaneurysm of the superior mesenteric artery with an arteriovenous fistula after simultaneous kidney-pancreas transplantation. Clin Transplant. Jun 1999;13(3):277-9. [Medline].

  31. Lee MJ, Saini S, Geller SC, et al. Pancreatitis with pseudoaneurysm formation: a pitfall for the interventional radiologist. AJR Am J Roentgenol. Jan 1991;156(1):97-8. [Medline].

  32. Lina JR, Jaques P, Mandell V. Aneurysm rupture secondary to transcatheter embolization. AJR Am J Roentgenol. Apr 1979;132(4):553-6. [Medline].

  33. Mandel SR, Jaques PF, Sanofsky S, et al. Nonoperative management of peripancreatic arterial aneurysms. A 10-year experience. Ann Surg. Feb 1987;205(2):126-8. [Medline].

  34. Marshall GT, Howell DA, Hansen BL, et al. Multidisciplinary approach to pseudoaneurysms complicating pancreatic pseudocysts. Impact of pretreatment diagnosis. Arch Surg. Mar 1996;131(3):278-83. [Medline].

  35. Morita R, Muto N, Konagaya M, et al. Successful transcatheter embolization of pseudoaneurysm associated with pancreatic pseudocyst. Am J Gastroenterol. Sep 1991;86(9):1264-7. [Medline].

  36. Sato N, Yamaguchi K, Shimizu S, et al. Coil embolization of bleeding visceral pseudoaneurysms following pancreatectomy: the importance of early angiography. Arch Surg. Oct 1998;133(10):1099-102. [Medline].

  37. Shankar S, Russell RC. Haemorrhage in pancreatic disease. Br J Surg. Aug 1989;76(8):863-6. [Medline].

  38. Shapiro N, Brandt L, Sprayregan S, et al. Duodenal infarction after therapeutic Gelfoam embolization of a bleeding duodenal ulcer. Gastroenterology. Jan 1981;80(1):176-80. [Medline].

  39. Sharara AI, Le TH, Suhocki P, et al. Extrahepatic biliary obstruction resulting from a pancreatic pseudoaneurysm. Gastrointest Endosc. Aug 1995;42(2):176-7. [Medline].

  40. Stabile BE, Wilson SE, Debas HT. Reduced mortality from bleeding pseudocysts and pseudoaneurysms caused by pancreatitis. Arch Surg. Jan 1983;118(1):45-51. [Medline].

  41. Stanley JC, Frey CF, Miller TA, et al. Major arterial hemorrhage: a complication of pancreatic pseudocysts and chronic pancreatitis. Arch Surg. Apr 1976;111(4):435-40. [Medline].

  42. Starling JR, Crummy AB. Hemosuccus pancreaticus secondary to ruptured splenic artery aneurysm. Dig Dis Sci. Sep 1979;24(9):726-29. [Medline].

  43. Stroud WH, Cullom JW, Anderson MC. Hemorrhagic complications of severe pancreatitis. Surgery. Oct 1981;90(4):657-65. [Medline].

  44. Trojanowski JQ, Harrist TJ, Athanasoulis CA, et al. Hepatic and splenic infarctions: complications of therapeutic transcatheter embolization. Am J Surg. Feb 1980;139(2):272-7. [Medline].

  45. Tsiotos GG, Munoz Juarez MM, Sarr MG. Intraabdominal hemorrhage complicating surgical management of necrotizing pancreatitis. Pancreas. Mar 1996;12(2):126-30. [Medline].

  46. van Berge Henegouwen MI, Allema JH, van Gulik TM, et al. Delayed massive haemorrhage after pancreatic and biliary surgery. Br J Surg. Nov 1995;82(11):1527-31. [Medline].

  47. Vanlangenhove P, Defreyne L, Kunnen M. Spontaneous thrombosis of a pseudoaneurysm complicating pancreatitis. Abdom Imaging. Sep-Oct 1999;24(5):491-3. [Medline].

  48. Waltman AC, Luers PR, Athanasoulis CA, et al. Massive arterial hemorrhage in patients with pancreatitis. Complementary roles of surgery and transcatheter occlusive techniques. Arch Surg. Apr 1986;121(4):439-43. [Medline].

  49. Wolstenholme JT. Major gastrointestinal hemorrhage associated with pancreatic pseudocyst. Am J Surg. Apr 1974;127(4):377-81. [Medline].

Previous
Next
 
Splenic artery angiogram demonstrating contrast (white arrow) extravasating into a pseudoaneurysm (black arrow).
A CT scan with intravenous contrast enhancement (arrow) within a pancreatic pseudocyst indicating the presence of a pseudoaneurysm.
Preembolization angiogram depicting a splenic artery pseudoaneurysm.
Postembolization angiogram depicting successful coil embolization of the pseudoaneurysm.
 
 
 
All material on this website is protected by copyright, Copyright © 1994-2012 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

DISCLAIMER: The content of this Website is not influenced by sponsors. The site is designed primarily for use by qualified physicians and other medical professionals. The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for educational and informational purposes only. In no way should it be considered as offering medical advice. Please check with a physician if you suspect you are ill.