Rectovaginal Fistula Workup
- Author: Dana Taylor, MD, FACS; Chief Editor: John Geibel, MD, DSc, MA more...
Laboratory Studies
- Laboratory studies (eg, complete blood cell [CBC] count, blood cultures, electrolytes, blood urea nitrogen [BUN], creatinine, type and screen) are obtained to assess for sepsis, which is extremely rare in fistulas between the GI and female genital tracts. Laboratory studies are also helpful in the establishment of preoperative baselines.
Imaging Studies
- Ancillary studies may illustrate a rectovaginal fistula (RVF) that is elusive on physical examination.[6]
- Barium enema can demonstrate RVF or the more common sigmoid-vaginal cuff fistula observed in diverticulitis.
- Computed tomography (CT) scanning often shows perifistular inflammation, identifying the responsible digestive organ.
Other Tests
- Physical examination is essential. This usually confirms the diagnosis of rectovaginal fistula (RVF) and affords much information regarding its size and location, the function of the sphincters, and the possibility of IBD or local neoplasm. (Anal sphincter disruptions are commonly seen in association with RVFs of obstetric origin. Sphincter function should be evaluated prior to any repair.)
- Office examination usually consists of a rectovaginal examination (visual and palpation) and proctosigmoidoscopy. The fistula opening may be seen as a small dimple or pit and occasionally can be gently probed for confirmation.
- The suspicion of Crohn disease should be high if there is any other abnormality of the rectal mucosa or a previous or currently coexisting fistula-in-ano. Failure to recognize Crohn disease can lead to inappropriate operative intervention and can worsen the patient's situation.
- Placing a vaginal tampon, instilling methylene blue into the rectum, and examining the tampon after 15-20 minutes can often establish the presence of RVF. If the tampon is unstained, another part of the GI tract may be involved.
- Endorectal and transvaginal ultrasonography may be used to help identify low fistulas.
Diagnostic Procedures
- Flexible endoscopy (sigmoidoscopy or colonoscopy) is used to fully evaluate the possibility of IBD. Because treatment varies according to the diagnosis, endoscopy with biopsies must precede any operative approach to the fistula, when IBD is in the differential diagnosis.
Histologic Findings
Histology is most important in the evaluation of possible IBD. Neither a diagnosis of ulcerative colitis nor of Crohn disease completely excludes operative repair of a rectovaginal fistula (RVF), but operative planning is altered, as is the prognosis. If the rectum is grossly normal in Crohn disease, the prognosis of RVF repair is fair. When the rectum is abnormal, prognosis is considerably worse. The histopathology of any fistula considered suggestive of primary or recurrent neoplasm is of the utmost importance.
Galandiuk S, Kimberling J, Al-Mishlab TG, et al. Perianal Crohn disease: predictors of need for permanent diversion. Ann Surg. May 2005;241(5):796-801; discussion 801-2. [Medline]. [Full Text].
Bangser M. Obstetric fistula and stigma. Lancet. Feb 11 2006;367(9509):535-6. [Medline].
Browning A, Menber B. Women with obstetric fistula in Ethiopia: a 6-month follow up after surgical treatment. BJOG. Nov 2008;115(12):1564-9. [Medline].
Bricker EM, Johnston WD. Repair of postirradiation rectovaginal fistula and stricture. Surg Gynecol Obstet. Apr 1979;148(4):499-506. [Medline].
Cohen JL, Stricker JW, Schoetz DJ, et al. Rectovaginal fistula in Crohn's disease. Dis Colon Rectum. Oct 1989;32(10):825-8. [Medline].
Shobeiri SA, Quiroz L, Nihira M. Rectovaginal fistulography: a technique for the identification of recurrent elusive fistulas. Int Urogynecol J Pelvic Floor Dysfunct. Jan 22 2009;[Medline].
Gonzalez-Lama Y, Abreu L, Vera MI, et al. Long-term oral tacrolimus therapy in refractory to infliximab fistulizing Crohn's disease: a pilot study. Inflamm Bowel Dis. Jan 2005;11(1):8-15. [Medline].
Laurent S, Barbeaux A, Detroz B, et al. Development of adenocarcinoma in chronic fistula in Crohn's disease. Acta Gastroenterol Belg. Jan-Mar 2005;68(1):98-100. [Medline].
Kumaran SS, Palanivelu C, Kavalakat AJ, et al. Laparoscopic repair of high rectovaginal fistula: is it technically feasible?. BMC Surg. 2005;5:20. [Medline]. [Full Text].
Casadesus D, Villasana L, Sanchez IM, et al. Treatment of rectovaginal fistula: a 5-year review. Aust N Z J Obstet Gynaecol. Feb 2006;46(1):49-51. [Medline].
Khanduja KS, Yamashita HJ, Wise WE Jr. Delayed repair of obstetric injuries of the anorectum and vagina. A stratified surgical approach. Dis Colon Rectum. Apr 1994;37(4):344-9. [Medline].
Jasonni VM, La Marca A, Manenti A. Rectovaginal fistula repair using fascia graft of autologous abdominal muscles. Int J Gynaecol Obstet. Jan 2006;92(1):85-6. [Medline].
Ellis CN. Outcomes after repair of rectovaginal fistulas using bioprosthetics. Dis Colon Rectum. Jul 2008;51(7):1084-8. [Medline].
Gonsalves S, Sagar P, Lengyel J, Morrison C, Dunham R. Assessment of the efficacy of the rectovaginal button fistula plug for the treatment of ileal pouch-vaginal and rectovaginal fistulas. Dis Colon Rectum. Nov 2009;52(11):1877-81. [Medline].
Ulrich D, Roos J, Jakse G, et al. Gracilis muscle interposition for the treatment of recto-urethral and rectovaginal fistulas: a retrospective analysis of 35 cases. J Plast Reconstr Aesthet Surg. Jan 20 2009;[Medline].
Schouten WR, Oom DM. Rectal sleeve advancement for the treatment of persistent rectovaginal fistulas. Tech Coloproctol. Dec 2009;13(4):289-94. [Medline].
Loffler T, Welsch T, Muhl S, et al. Long-term success rate after surgical treatment of anorectal and rectovaginal fistulas in Crohn's disease. Int J Colorectal Dis. Jan 27 2009;[Medline].
El-Gazzaz G, Hull T, Mignanelli E, Hammel J, Gurland B, Zutshi M. Analysis of function and predictors of failure in women undergoing repair of Crohn's related rectovaginal fistula. J Gastrointest Surg. May 2010;14(5):824-9. [Medline].
Burke C. Rectovaginal fistulas. Clin J Oncol Nurs. Jun 2005;9(3):295-7. [Medline].
Fry RD, Kodner IJ. Rectovaginal fistula. Surg Annu. 1995;27:113-31. [Medline].
Hilger WS, Cornella JL. Rectovaginal fistula after posterior intravaginal slingplasty and polypropylene mesh augmented rectocele repair. Int Urogynecol J Pelvic Floor Dysfunct. Jan 2006;17(1):89-92. [Medline].
Husain A, Johnson K, Glowacki CA, et al. Surgical management of complex obstetric fistula in Eritrea. J Womens Health (Larchmt). Nov 2005;14(9):839-44. [Medline].
MacRae HM, McLeod RS, Cohen Z. Treatment of rectovaginal fistulas that has failed previous repair attempts. Dis Colon Rectum. Sep 1995;38(9):921-5. [Medline].
Miklos JR, Kohli N. Rectovaginal fistula repair utilizing a cadaveric dermal allograft. Int Urogynecol J Pelvic Floor Dysfunct. 1999;10(6):405-6. [Medline].
Moore RD, Miklos JR, Kohli N. Rectovaginal fistula repair using a porcine dermal graft. Obstet Gynecol. Nov 2004;104(5 Pt 2):1165-7. [Medline].
Nowacki MP. Ten years of experience with Parks' coloanal sleeve anastomosis for the treatment of post-irradiation rectovaginal fistula. Eur J Surg Oncol. Dec 1991;17(6):563-6. [Medline].
Steichen FM, Barber HK, Loubeau JM, et al. Bricker-Johnston sigmoid colon graft for repair of postradiation rectovaginal fistula and stricture performed with mechanical sutures. Dis Colon Rectum. Jun 1992;35(6):599-603. [Medline].
Tsang CB, Madoff RD, Wong WD. Anal sphincter integrity and function influences outcome in rectovaginal fistula repair. Dis Colon Rectum. Sep 1998;41(9):1141-6. [Medline].
Tsang CB, Rothenberger DA. Rectovaginal fistulas. Therapeutic options. Surg Clin North Am. Feb 1997;77(1):95-114. [Medline].

