Obsessive-Compulsive Disorder Clinical Presentation
- Author: William M Greenberg, MD; Chief Editor: David Bienenfeld, MD more...
History
OCD is diagnosed primarily by presentation and history. The age of onset and any history of tics (either current or past) should be established.
Elements that are covered when obtaining a patient’s history should also include details relating to the nature and severity of symptoms.[22]
Questions regarding the nature and severity of obsessive symptoms
Have you ever been bothered by thoughts that do not make any sense and keep coming back to you even when you try not to have them?
When you had these thoughts, did you try to get them out of your head? What would you try to do?
Where do you think these thoughts were coming from?
Questions regarding the nature and severity of compulsive symptoms
Has there ever been anything that you had to do over and over again and could not resist doing, such as repeatedly washing your hands, counting up to a certain number, or checking something several times to make sure you had done it right?
What behavior did you have to do?
Why did you have to do the repetitive behavior?
How many times would you do it and how long would it take?
Did these thoughts or actions take more time than you think makes sense?
What effect did they have on your life?
Psychiatric review of systems and comorbidities
Individuals with OCD frequently have other psychiatric comorbid disorders, prominently including major depressive disorder, alcohol and/or substance use disorders, other anxiety disorders, impulse control disorders (eg, trichotillomania, skin-picking), and Tourette and tic disorders. (Perhaps 40% of individuals with Tourette disorder will have OCD). Therefore, in taking a psychiatric history, the focus should be on identifying such comorbidities, seeking to elicit the following:
- Mood and anxiety symptoms
- Somatoform disorders, especially hypochondriasis and body dysmorphic disorder
- Eating disorders
- Impulse control disorders, especially kleptomania and trichotillomania
- ADHD
Childhood-onset OCD may have a higher rate of comorbidity with Tourette disorder and ADHD.
The co-occurrence of schizophrenia and OCD is problematic for a variety of reasons. Not infrequently, individuals with schizophrenia do seem to have significant OC symptoms (sometimes, ironically, caused or exacerbated by the use of the very effective antipsychotic clozapine, whereas adjunctive antipsychotics may lessen treatment-resistant OC symptoms in those who do not have schizophrenia).
When OC symptoms are present in someone who has schizophrenia, they may meet criteria for a diagnosis of OCD, but such patients often respond poorly to the usual OCD treatments, and perhaps OCD in schizophrenia has a different pathophysiology.
Consider the following:
- Family history of OCD, Tourette disorder, tics, ADHD, and other psychiatric diagnoses
- Current or past substance abuse or dependence
- Antecedent infections, especially streptococcal and herpetic infection
Common obsessions include the following:
- Contamination
- Safety
- Doubting one's memory or perception
- Scrupulosity (need to do the right thing, fear of committing a transgression, often religious)
- Need for order or symmetry
- Unwanted, intrusive sexual/aggressive thought
Common compulsions include the following:
- Cleaning/washing
- Checking (checking locks, stove, iron, safety of children)
- Counting/repeating actions a certain number of times or until it "feels right"
- Arranging objects
- Touching/tapping objects
- Hoarding
- Confessing/seeking reassurance
- List making
Interpersonal relationships
OCD symptoms can interact negatively with interpersonal relationships, and families can become involved with the illness in a counterproductive way. For example, a patient with severe doubting obsessions may constantly ask reassurance for irrational fears from family members or significant others; constantly providing this can inhibit the patient from making attempts to work on their behavioral disturbances).
Physical Examination
Skin findings in OCD may include the following:
- Eczematous eruptions related to excessive washing
- Hair loss related to trichotillomania or compulsive hair pulling
- Excoriations related to neurodermatitis or compulsive skin picking
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th Edition, Text Revision (DSM-IV-TR). Washington, DC: American Psychiatric Association; 2000.
Bienvenu OJ, Samuels JF, Wuyek LA, Liang KY, Wang Y, Grados MA, et al. Is obsessive-compulsive disorder an anxiety disorder, and what, if any, are spectrum conditions? A family study perspective. Psychol Med. Jan 2012;42(1):1-13. [Medline].
Bartz JA, Hollander E. Is obsessive-compulsive disorder an anxiety disorder?. Prog Neuropsychopharmacol Biol Psychiatry. May 2006;30(3):338-52. [Medline].
Dell'Osso B, Altamura AC, Allen A, Marazziti D, Hollander E. Epidemiologic and clinical updates on impulse control disorders: a critical review. Eur Arch Psychiatry Clin Neurosci. Dec 2006;256(8):464-75. [Medline]. [Full Text].
Castle DJ, Phillips KA. Obsessive-compulsive spectrum of disorders: a defensible construct?. Aust N Z J Psychiatry. Feb 2006;40(2):114-20. [Medline]. [Full Text].
Greist JH, Jefferson JW, Kobak KA, Katzelnick DJ, Serlin RC. Efficacy and tolerability of serotonin transport inhibitors in obsessive-compulsive disorder. A meta-analysis. Arch Gen Psychiatry. Jan 1995;52(1):53-60. [Medline].
Kobak KA, Greist JH, Jefferson JW, Katzelnick DJ, Henk HJ. Behavioral versus pharmacological treatments of obsessive compulsive disorder: a meta-analysis. Psychopharmacology (Berl). Apr 1998;136(3):205-16. [Medline].
Bloch MH, Landeros-Weisenberger A, Kelmendi B, Coric V, Bracken MB, Leckman JF. A systematic review: antipsychotic augmentation with treatment refractory obsessive-compulsive disorder. Mol Psychiatry. Jul 2006;11(7):622-32. [Medline].
Baxter LR Jr, Schwartz JM, Bergman KS, Szuba MP, Guze BH, Mazziotta JC, et al. Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive-compulsive disorder. Arch Gen Psychiatry. Sep 1992;49(9):681-9. [Medline].
Pittenger C, Krystal JH, Coric V. Glutamate-modulating drugs as novel pharmacotherapeutic agents in the treatment of obsessive-compulsive disorder. NeuroRx. Jan 2006;3(1):69-81. [Medline].
van Grootheest DS, Cath DC, Beekman AT, Boomsma DI. Twin studies on obsessive-compulsive disorder: a review. Twin Res Hum Genet. Oct 2005;8(5):450-8. [Medline].
Carey G, Gottesman I. Twin and family studies of anxiety, phobic, and obsessive disorders. In: Klein DF, Rabkin JG. Anxiety: New Research and Changing Concepts. New York: Raven Press; 2000.
Arnold PD, Rosenberg DR, Mundo E, Tharmalingam S, Kennedy JL, Richter MA. Association of a glutamate (NMDA) subunit receptor gene (GRIN2B) with obessive-compulsive disorder: a preliminary study. Psychopharmacology. August 2004;174:530-538.
Arnold PD, Sicard T, Burroughs E, Richter MA, Kennedy JL. Glutamate transporter gene SLC1A1 associated with obsessive-compulsive disorder. Arch Gen Psychiatry. Jul 2006;63(7):769-76. [Medline].
Denys D, Van Nieuwerburgh F, Deforce D, Westenberg H. Association between the dopamine D2 receptor TaqI A2 allele and low activity COMT allele with obsessive-compulsive disorder in males. Eur Neuropsychopharmacol. Aug 2006;16(6):446-50. [Medline].
Dickel DE, Veenstra-VanderWeele J, Cox NJ, Wu X, Fischer DJ, Van Etten-Lee M, et al. Association testing of the positional and functional candidate gene SLC1A1/EAAC1 in early-onset obsessive-compulsive disorder. Arch Gen Psychiatry. Jul 2006;63(7):778-85. [Medline].
Lin PY. Meta-analysis of the association of serotonin transporter gene polymorphism with obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry. Apr 13 2007;31(3):683-9. [Medline].
Karno M, Golding JM, Sorenson SB, Burnam MA. The epidemiology of obsessive-compulsive disorder in five US communities. Arch Gen Psychiatry. Dec 1988;45(12):1094-9. [Medline].
Rapoport JL. The Boy Who Couldn't Stop Washing: The Experience and Treatment of Obsessive-Compulsive Disorder. paperback. New York: Penguin Putnam; 2001.
[Guideline] American Psychiatric Association Work Group on Obsessive-Compulsive Disorder. Practice guideline for the treatment of patients with obsessive-compulsive disorder. Am J Psychiatry. July 2007;164(suppl):1-56. [Full Text].
Foa EB, Wilson R. Stop Obsessing!: How to Overcome Your Obsessions and Compulsions. Revis ed. New York: Bantam Dell; 2001.
First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV-TR Axis I Disorders - Patient Edition (SCID-I/P, 11/2002 revision). New York: Biometrics Research Department, New York State Psychiatric Institute; November 2002.
Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL, et al. The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability. Arch Gen Psychiatry. Nov 1989;46(11):1006-11. [Medline].
Coric V, Taskiran S, Pittenger C, Wasylink S, Mathalon DH, Valentine G, et al. Riluzole augmentation in treatment-resistant obsessive-compulsive disorder: an open-label trial. Biol Psychiatry. Sep 1 2005;58(5):424-8. [Medline].
Greenberg WM, Benedict MM, Doerfer J, Perrin M, Panek L, Cleveland WL, et al. Adjunctive glycine in the treatment of obsessive-compulsive disorder in adults. J Psychiatr Res. Mar 2009;43(6):664-70. [Medline].
Berlin HA, Koran LM, Jenike MA, et al. Double-blind, placebo-controlled trial of topiramate augmentation in treatment-resistant obsessive-compulsive disorder. J Clin Psychiatry. May 2011;72(5):716-21. [Medline].
Grayson J. Freedom From Obsessive Compulsive Disorder: A Personalized Recovery Program for Living With Uncertainty. New York: Berkley Publishing Group; 2004.
Greenberg BD, Malone DA, Friehs GM, Rezai AR, Kubu CS, Malloy PF, et al. Three-year outcomes in deep brain stimulation for highly resistant obsessive-compulsive disorder. Neuropsychopharmacology. Nov 2006;31(11):2384-93. [Medline].
Mallet L, Polosan M, Jaafari N, Baup N, Welter ML, Fontaine D, et al. Subthalamic nucleus stimulation in severe obsessive-compulsive disorder. N Engl J Med. Nov 13 2008;359(20):2121-34. [Medline].
Jung HH, Kim CH, Chang JH, Park YG, Chung SS, Chang JW. Bilateral anterior cingulotomy for refractory obsessive-compulsive disorder: Long-term follow-up results. Stereotact Funct Neurosurg. 2006;84(4):184-9. [Medline].
Celexa (citalopram hydrobromide) [package insert]. St. Louis, Missouri: Forest Pharmaceuticals, Inc; August, 2011. [Full Text].
US Food and Drug Administration. Celexa (citalopram hydrobromide): Drug safety communication – abnormal heart rhythms associated with high doses. Available at http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm269481.htm. Accessed August 24, 2011.
Komossa K, Depping AM, Meyer M, Kissling W, Leucht S. Second-generation antipsychotics for obsessive compulsive disorder. Cochrane Database Syst Rev. Dec 8 2010;12:CD008141. [Medline].
FDA Public Health Advisory: Suicidality in Children and Adolescents Being Treated With Antidepressant Medications. FDA Website. October 15, 2004;1-3. [Full Text].
FDA Proposes New Warnings About Suicidal Thinking, Behavior in Young Adults Who Take Antidepressant Medications. FDA Website. May 2, 2007;1-3. [Full Text].
| Obsessions | Commonly Associated Compulsions |
| Fear of contamination | Washing, cleaning |
| Need for symmetry, precise arranging | Ordering, arranging, balancing, straightening until "just right" |
| Unwanted sexual or aggressive thoughts or images | Checking, praying, “undoing” actions, asking for reassurance |
| Doubts (eg, gas jets off, doors locked) | Repeated checking behaviors |
| Concerns about throwing away something valuable | Hoarding |

