Pyelonephritis Organism-Specific Therapy 

Updated: Nov 30, 2015
  • Author: Mony Fraer, MD, MHCDS, FACP, FASN; Chief Editor: Thomas E Herchline, MD  more...
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Specific Organisms and Therapeutic Regimens

Organism-specific therapeutic regimens for pyelonephritis are provided below, including those for the following [1, 2, 3] :

  • Escherichia coli
  • Staphylococcus saprophyticus
  • Staphylococcus aureus
  • Proteus species (spp)
  • Klebsiella spp
  • Enterococcus spp

E coli

See the list below:

S saprophyticus

See the list below:

S aureus

See the list below:

  • Trimethoprim-sulfamethoxazole (160/800 mg) 1 DS tablet PO q12 h or
  • Ampicillin 500 mg PO q6 h or 2 g IV q6h

Proteus spp

See the list below:

  • Ampicillin 500 mg PO q6 h or 2 g IV q6 h or
  • Ciprofloxacin 500 mg PO q12 h or
  • Levofloxacin 500 mg IV q24 h or
  • Ceftriaxone 1 g IV q24 h

Klebsiella spp

See the list below:

  • Ciprofloxacin 500 mg PO q12 h or
  • Levofloxacin 500 mg IV q24 h or
  • Ceftriaxone 1 g IV q24 h

Enterococcus spp

See the list below: