Glanzmann Thrombasthenia Clinical Presentation
- Author: Zonera Ashraf Ali, MBBS; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP more...
The clinical history of Glanzmann thrombasthenia may include the following:
- Excessive bleeding after dental extraction (this may often be the first sign of the disease)
- Petechiae and ecchymoses (although spontaneous petechiae are uncommon)
- Menorrhagia, often worse at menarche
- Gingival bleeding (which is worse with poor dental hygiene)
- Hemarthroses (rare)
- Family history of a bleeding disorder may or may not exist
- Gastrointestinal bleeding or hematuria is less common
See the list below:
- In patients suspected with of Glanzmann thrombasthenia, examine the skin and oral mucosa for petechiae, ecchymoses, and any current bleeding.
- The spleen should normally be nonpalpable.
See the list below:
- Glanzmann thrombasthenia is a genetic condition. The disease is clinically apparent in patients who are homozygous. Glanzmann thrombasthenia is normally of no clinical significance in patients who are heterozygous for this condition.
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