Phases of Chronic Myelogenous Leukemia
Table. Phases of Chronic Myelogenous (Open Table in a new window)
|CML phase||WHO definition|
|Chronic stable phase||Peripheral blood blasts fewer than 10% in the blood and bone marrow|
|Accelerated phase||Blasts 10-19% of white blood cells in peripheral and/or nucleated bone marrow cells ; persistent thrombocytopenia (< 100 × 109/L) unrelated to therapy or persistent thrombocytosis (> 1000 × 109/L) unresponsive to therapy; increasing white blood cells and spleen size unresponsive to therapy; cytogenetic evidence of clonal evolution|
|Blast crisis||Peripheral blood blasts ≥ 20% of peripheral blood white blood cells or nucleated bone marrow cells; extramedullary blast proliferation; and large foci or clusters of blasts on bone marrow biopsy|
See Chronic Leukemias: 4 Cancers to Differentiate, a Critical Images slideshow, to help detect chronic leukemias and determine the specific type present.