Acute Myeloid Leukemia Staging 

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Updated: Dec 30, 2015
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...

FAB and WHO Classifications for Acute Myeloid Leukemia

Two staging systems are commonly used for acute myeloid leukemia (AML). The French-American-British (FAB) classification system is based on morphology to define specific immunotypes. The World Health Organization (WHO) classification reviews chromosome translocations and evidence of dysplasia. [1]

Table. FAB classification of AML (Open Table in a new window)

FAB subtype Name Adult AML patients (%)
M0 Undifferentiated acute myeloblastic leukemia 5%
M1 Acute myeloblastic leukemia with minimal maturation 15%
M2 Acute myeloblastic leukemia with maturation 25%
M3 Acute promyelocytic leukemia 10%
M4 Acute myelomonocytic leukemia 20%
M4eos Acute myelomonocytic leukemia with eosinophilia 5%
M5 Acute monocytic leukemia 10%
M6 Acute erythroid leukemia 5%
M7 Acute megakaryocytic leukemia 5%

WHO classification of AML and related neoplasms

AML with recurrent genetic abnormalities [2, 3] :

  • AML with t(8;21)(q22;q22); RUNX1-RUNX1T1
  • AML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBEB-MYH11
  • Acute promyelocytic leukemia (APL) with t(15;17)(q22;q12); PML-RARA
  • AML with t(9;11)(p22;q23); MLLT3-MLL
  • AML with t(6;9)(p23;q34); DEK-NUP214
  • AML with inv(3)(q21q26.2) or t(3;3)(q21;q26.2); RPN1-EVI1
  • AML (megakaryoblastic) with t(1;22)(p13;q13); RBM15-MKL1
  • Provisional entity: AML with mutated NPM1
  • Provisional entity: AML with mutated CEBPA

AML with myelodysplasia-related change

Therapy-related myeloid neoplasms

AML, not otherwise specified:

  • Undifferentiated AML (M0)
  • AML with minimal differentiation (M1)
  • AML without maturation (M2)
  • AML with maturation (M2)
  • Acute myelomonocytic leukemia (M3)
  • Acute monoblastic/monocytic leukemia (M4)
  • Acute erythroid leukemia (M5)
  • Pure erythroid leukemia (M6)
  • Erythroleukemia, erythroid/myeloid (M6)
  • Acute megakaryoblastic leukemia (M7)
  • Acute basophilic leukemia
  • Acute panmyelosis with myelofibrosis

Myeloid sarcoma

Myeloid proliferations related to Down syndrome:

  • Transient abnormal myelopoiesis
  • Myeloid leukemia associated with Down syndrome

Blastic plasmacytoid dendritic cell neoplasm