Endometrial Cancer Staging 

Updated: Nov 17, 2015
  • Author: William T Creasman, MD; Chief Editor: from Memorial Sloan-Kettering - Yukio Sonoda, MD  more...
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TNM Classification for Endometrial Cancer

The TNM classification for staging of endometrial cancer is provided below. [1, 2]

Table. TNM Classification for Endometrial Cancer (Open Table in a new window)

Primary tumor (T)
TNM FIGO stages Surgical-pathologic findings
TX   Primary tumor cannot be assessed
T0   No evidence of primary tumor
Tis*   Carcinoma in situ (preinvasive carcinoma)
T1 I Tumor confined to corpus uteri
T1a IA Tumor limited to endometrium or invades less than one half of the myometrium
T1b IB Tumor invades one half or more of the myometrium
T2 II Tumor invades stromal connective tissue of the cervix but does not extend beyond uterus**
T3a IIIA Tumor involves serosa and/or adnexa (direct extension or metastasis)
T3b IIIB Vaginal involvement (direct extension or metastasis) or parametrial involvement
  IIIC Metastases to pelvic and/or para-aortic lymph nodes
  IV Tumor invades bladder mucosa and/or bowel mucosa, and/or distant metastases
T4 IVA Tumor invades bladder mucosa and/or bowel mucosa (bullous edema is not sufficient to classify a tumor as T4)
*FIGO no longer includes stage 0 (Tis)



**Endocervical glandular involvement should only be considered as stage I and no longer as stage II



Regional lymph nodes (N)
TNM FIGO stages Surgical-pathologic findings
NX   Regional lymph nodes cannot be assessed
N0   No regional lymph node metastasis
N1 IIIC1 Regional lymph node metastasis to pelvic lymph nodes
N2 IIIC2 Regional lymph node metastasis to para-aortic lymph nodes, with or without positive pelvic lymph nodes
Distant metastasis (M)
TNM FIGO stages Surgical-pathologic findings
M0   No distant metastasis
M1 IVB Distant metastasis (includes metastasis to inguinal lymph nodes, intraperitoneal disease, or lung, liver, or bone metastases; it excludes metastasis to para-aortic lymph nodes, vagina, pelvic serosa, or adnexa)