Osteogenic Sarcoma Staging 

  • Author: Edwin Choy, MD, PhD; Chief Editor: Jules E Harris, MD   more...
 
Updated: May 20, 2011
 
 

TNM Classification for Osteogenic Sarcoma

The TNM classification for staging of osteogenic sarcoma is provided below.[1, 2]

Table. TNM Classification for Osteogenic Sarcoma (Open Table in a new window)

Primary tumor (T)
TXPrimary tumor cannot be assessed
T0No evidence of primary tumor
T1Tumor ≤ 8 cm in greatest dimension
T2Tumor > 8 cm in greatest dimension
T3Discontinuous tumors in the primary bone site
Regional lymph nodes (N)
NXRegional lymph nodes cannot be assessed
N0No regional node metastasis
N1Regional lymph node metastasis
Distant metastasis (M)
MXDistant metastasis cannot be assessed
M0No distant metastasis
M1aLung only
M1bOther distant sites

Table. Histologic grade (Open Table in a new window)

Histologic grade (G)
GXGrade cannot be assessed
G1Well differentiated – low grade
G2Moderately differentiated – low grade
G3Poorly differentiated
G4Undifferentiated

Table. Stage grouping (Open Table in a new window)

StageTNMGrade
IAT1N0M0G1,2 low grade, GX
IBT2N0M0G1,2 low grade, GX
T3N0M0G1,2 low grade, GX
IIAT1N0M0G3,4 high grade
IIBT2N0M0G3,4 high grade
IIIT3N0M0G3
IVAAny TN0M1aAny G
IVBAny TN1Any MAny G
IVBAny TAny NM1bAny G
 
Contributor Information and Disclosures
Author

Edwin Choy, MD, PhD  Attending Physician, Division of Hematology/Oncology, Massachusetts General Hospital

Edwin Choy, MD, PhD is a member of the following medical societies: American Society of Clinical Oncology

Disclosure: Amgen Honoraria Advisory Board Participation; Novartis Grant/research funds Clinical Trial Development; Pharmacyclics Grant/research funds Clinical Trial Development

Specialty Editor Board

Jasmeet Anand, PharmD, RPh  Adjunct Instructor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Christopher D Braden, DO  Hematologist/Oncologist, Chancellor Center for Oncology at Deaconess Hospital; Hematologist/Oncologist, St Francis Hospital System Cancer Center

Disclosure: Nothing to disclose.

Chief Editor

Jules E Harris, MD  Clinical Professor of Medicine, Division of Hematology/Medical Oncology, Department of Internal Medicine, University of Arizona College of Medicine; Consulting Staff, Arizona Cancer Center

Jules E Harris, MD is a member of the following medical societies: American Association for Cancer Research, American Association for the Advancement of Science, American Association of Immunologists, American Society of Hematology, and Central Society for Clinical Research

Disclosure: GlobeImmune Salary Consulting

References
  1. Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A, eds. AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer-Verlag; 2010.

  2. NCCN Clinical Practice Guidelines in Oncology: Bone Cancer. Available at http://www.nccn.org/professionals/physician_gls/pdf/bone.pdf. Accessed March 28, 2011.

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Table. TNM Classification for Osteogenic Sarcoma
Primary tumor (T)
TXPrimary tumor cannot be assessed
T0No evidence of primary tumor
T1Tumor ≤ 8 cm in greatest dimension
T2Tumor > 8 cm in greatest dimension
T3Discontinuous tumors in the primary bone site
Regional lymph nodes (N)
NXRegional lymph nodes cannot be assessed
N0No regional node metastasis
N1Regional lymph node metastasis
Distant metastasis (M)
MXDistant metastasis cannot be assessed
M0No distant metastasis
M1aLung only
M1bOther distant sites
Table. Histologic grade
Histologic grade (G)
GXGrade cannot be assessed
G1Well differentiated – low grade
G2Moderately differentiated – low grade
G3Poorly differentiated
G4Undifferentiated
Table. Stage grouping
StageTNMGrade
IAT1N0M0G1,2 low grade, GX
IBT2N0M0G1,2 low grade, GX
T3N0M0G1,2 low grade, GX
IIAT1N0M0G3,4 high grade
IIBT2N0M0G3,4 high grade
IIIT3N0M0G3
IVAAny TN0M1aAny G
IVBAny TN1Any MAny G
IVBAny TAny NM1bAny G
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