Urethritis Organism-Specific Therapy 

Updated: Jan 13, 2016
  • Author: Thomas E Herchline, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Specific Organisms and Therapeutic Regimens

Organism-specific therapeutic regimens for urethritis are provided below, including those for the following [1, 2, 3, 4, 5, 6] :

  • Neisseria gonorrhoeae
  • Chlamydia trachomatis
  • Ureaplasma urealyticum
  • Mycoplasma hominis
  • Mycoplasma genitalium.

Neisseria gonorrhoeae (gonococcal urethritis):

  • Ceftriaxone 250 mg IM in a single dose (strongly preferred) plus
  • Azithromycin 1 g PO in a single dose or
  • Doxycycline 100 mg PO BID for 7 days (if allergic to azithromycin)

If ceftriaxone is not available:

  • Cefixime 400 mg PO in a single dose plus
  • Azithromycin 1 g PO in a single dose or
  • Doxycycline 100 mg PO BID for 7 days  (if allergic to azithromycin)

If patient has a severe cephalosporin allergy:

  • Azithromycin 2 g PO in a single dose plus
  • Gemifloxacin 320 mg PO in a single dose or
  • Gentamicin 240 mg IM in a single dose

Chlamydia trachomatis:

Ureaplasma urealyticum:

  • Doxycycline 100 mg PO BID for 7d

Mycoplasma hominis:

  • Azithromycin 1 g PO in a single dose or
  • Doxycycline 100 mg PO BID for 7d or
  • Erythromycin base 500 mg PO QID for 7d or
  • Erythromycin ethylsuccinate 800 mg PO QID for 7d

Mycoplasma genitalium

  • Azithromycin 1 g PO in a single dose