eMedicine Specialties > Hematology > Coagulation, Hemostasis, and Disorders
Factor VIII: Multimedia
Updated: Aug 13, 2009
Multimedia
 | Media file 1: Obituary in the March 22, 1796, Salem Gazette (Massachusetts) for a 19-year-old man who bled to death after suffering a foot injury. Also detailed are the deaths of 5 brothers by various minor injuries. |
 | Media file 2: The hemostatic pathway: role of factor VIII. |
 | Media file 3: Structural domains of human factor VIII. Adapted from: Stoilova-McPhie S, Villoutreix BO, Mertens K, Kemball-Cook G, Holzenburg A. 3-Dimensional structure of membrane-bound coagulation factor VIII: modeling of the factor VIII heterodimer within a 3-dimensional density map derived by electron crystallography. Blood. Feb 15 2002;99(4):1215-23 45; Roberts HR, Hoffman M. Hemophilia A and B. In: Beutler E, Lichtman MA, Coller BS, et al, eds. Williams Hematology. 6th ed. NY: McGraw-Hill; 2001:1639-57 34; and Roberts HR. Thoughts on the mechanism of action of FVIIa. Presented at: Second Symposium on New Aspects of Haemophilia Treatment; 1991; Copenhagen, Denmark. 46 |
 | Media file 4: Cell surface–directed hemostasis (adapted from: Hoffman M, Monroe DM 3rd. A cell-based model of hemostasis. Thromb Haemost. Jun 2001;85(6):958-65. 47). Initially, a small amount of thrombin is generated on the surface of the tissue factor–bearing cell. Following amplification, the second burst generates a larger amount of thrombin, leading to fibrin (clot) formation. |
 | Media file 5: Possible genetic outcomes in individuals carrying the hemophilic gene. |
 | Media file 6: Photograph of a teenage boy with bleeding into his right thigh as well as both knees and ankles. |
 | Media file 7: Photograph of the right knee in an older man with a chronically fused, extended knee following open drainage of knee bleeding that occurred many years previously. |
 | Media file 8: Photograph depicting severe bilateral hemophilic arthropathy and muscle wasting. The 3 punctures made into the left knee joint were performed in an attempt to aspirate recent aggravated bleeding. |
 | Media file 9: Radiograph depicting advanced hemophilic arthropathy of the knee joint. These images show chronic severe arthritis, fusion, loss of cartilage, and joint space deformities. |
 | Media file 10: Radiograph depicting advanced hemophilic arthropathy of the elbow. This image shows chronic severe arthritis, fusion, loss of cartilage, and joint space deformities. |
 | Media file 11: Photograph of a hemophilic knee at surgery, with synovial proliferation caused by repeated bleeding; synovectomy was required. |
 | Media file 12: Large amount of vascular synovium removed at surgery (same knee as in Image 11). |
 | Media file 13: Microscopic appearance of synovial proliferation and high vascularity. If stained with iron, diffuse deposits would be demonstrated; iron-laden macrophages are present. |
 | Media file 14: Large pseudocyst involving the left proximal femur. |
 | Media file 15: Transected pseudocyst (following disarticulation of the left lower extremity due to vascular compromise, nerve damage, loss of bone, and nonfunctional limb). This photo shows black-brown old blood, residual muscle, and bone. |
 | Media file 16: Dissection of a pseudocyst. |
 | Media file 17: Transected pseudocyst with chocolate brown-black old blood. |
 | Media file 18: Photograph of a patient who presented with a slowly expanding abdominal and flank mass, as well as increasing pain, inability to eat, weight loss, and weakness of his lower extremity. |
 | Media file 19: Plain radiograph of the pelvis showing a large lytic area. |
 | Media file 20: Intravenous pyelogram showing extreme displacement of the left kidney and ureter by a pseudocyst. |
 | Media file 21: Photograph depicting extensive spontaneous abdominal wall hematoma and thigh hemorrhage in an older, previously unaffected man with an acquired factor VIII inhibitor. |
 | Media file 22: Magnetic resonance image of an extensive spontaneous abdominal wall hematoma and thigh hemorrhage in an older, previously unaffected man with an acquired factor VIII inhibitor (same patient as in Image 21). |
 | Media file 23: Image depicting the 28q region of the X chromosome. Adapted from: Kazazian HH Jr, Tuddenham EGD, Antonarakis SE. Hemophilia A and parahemophilia: deficiencies of coagulation factors VIII and V. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolic and Molecular Bases of Inherited Disease. 7th ed. New York, NY: McGraw-Hill; 1995:3241-67 4; Reitsma PH. Genetic principles underlying disorders of procoagulant and anticoagulant proteins. In: Coleman RW, Hirsh J, Marder VJ, et al, eds. Hemostasis and Thrombosis: Basic Principles & Clinical Practice. 4th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2001:59-87 5; Roberts HR, Monroe DM III, Hoffman M. Molecular biology and biochemistry of the coagulation factors and pathways of hemostasis. In: Beutler E, Beutler E, Lichtman MA, et al, eds. Williams Hematology. 6th ed. New York: McGraw-Hill, 2001:1409-34 17; and Roberts HR, Hoffman M. Hemophilia A and B. In: Beutler E, Lichtman MA, et al, eds. Williams Hematology. 6th ed. New York: McGraw-Hill, 2001:1639-57. 34 |
 | Media file 24: Quality of life! A child with hemophilia at summer camp. |
 | Media file 25: Photograph depicting the application of a Velcro tourniquet, followed by self-infusion of concentrate used for in-home therapy (see Image 26). |
 | Media file 26: Self-infusion of concentrate used for in-home therapy (same patient as in Image 25). |
More on Factor VIII |
| Overview: Factor VIII |
| Differential Diagnoses & Workup: Factor VIII |
| Treatment & Medication: Factor VIII |
| Follow-up: Factor VIII |
 Multimedia: Factor VIII |
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Further Reading
Keywords
factor VIII, hemophilia, von Willebrand, von Willebrand disease, von Willebrands, hemophilia A, factor 8, blood coagulation factor VIII, factor VIII coagulant activity, F8, coagulation factor VIII, F VIII-C, FVIII-C, F VIII clotting activity, FVIII clotting activity, antihemophilic globulin, blood disease, blood disorder, hematologic disorder, bleeding disorder, hemostatic system, plasma coagulation system, hemophilia B, haemophilia, hemorrhagic disorder, coagulation disorder, clotting disorder, blood clotting, coagulopathies, coagulopathy, cryoprecipitate, plasma concentrate, F8A gene, F8B gene, ERGIC53 gene, combined deficiency of FV and FVIII, PLAS+SD, Advate, DDAVP, Stimate, EACA, AMCA, Cyklokapron
